Matches in SemOpenAlex for { <https://semopenalex.org/work/W2787014790> ?p ?o ?g. }
- W2787014790 abstract "Abstract DNA damage accumulates with age 1 . However, whether and how robust DNA repair machinery promotes longevity is elusive. Here, we demonstrate that activation of ataxia-telangiectasia mutated (ATM) via low dose of chloroquine (CQ) promotes DNA damage clearance, rescues age-related metabolic shift, and extends lifespan in nematodes and mice. Molecularly, ATM phosphorylates SIRT6 deacetylase and thus prevents MDM2-mediated ubiquitination and proteasomal degradation. Extra copies of Sirt6 in Atm -/- mice extend lifespan, accompanied with restored metabolic homeostasis. In a progeria mouse model with low ATM protein level and DNA repair capacity, the treatment with CQ ameliorates premature aging features and extends lifespan. Thus, our data highlights a pro-longevity role of ATM, for the first time establishing direct causal links between robust DNA repair machinery and longevity, and providing therapeutic strategy for progeria and age-related metabolic diseases." @default.
- W2787014790 created "2018-02-23" @default.
- W2787014790 creator A5009919513 @default.
- W2787014790 creator A5015086715 @default.
- W2787014790 creator A5020173371 @default.
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- W2787014790 creator A5079137395 @default.
- W2787014790 creator A5090898523 @default.
- W2787014790 date "2017-12-28" @default.
- W2787014790 modified "2023-09-29" @default.
- W2787014790 title "Boosting ATM Activity Promotes Longevity in Nematodes and Mice" @default.
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