Matches in SemOpenAlex for { <https://semopenalex.org/work/W2787016263> ?p ?o ?g. }
- W2787016263 endingPage "e00519" @default.
- W2787016263 startingPage "e00519" @default.
- W2787016263 abstract "Assessing immune response after rotavirus vaccination consists in measuring serum or plasma IgA and IgG antibodies, but these assays provide very little information about the mucosal immune response. Thus the development of assays for detection of mucosal immune response following rotavirus vaccination is essential. We evaluate to assess circulating antibody-secreting cells (ASCs) as a potential means to evaluate mucosal immune responses to rotavirus vaccine.372 subjects, aged 6 weeks, were enrolled in the study. All the subjects were assigned to receive two doses of Rotarix® vaccine. Using a micro-modified whole blood-based ELISPOT assay, circulating rotavirus type-specific IgA- and IgG-ASCs, including gut homing β7+ ASCs, were enumerated on week 6 before the first dose of Rotarix vaccination at 7 weeks of age and week 18 after the second vaccination at 17 weeks of age. Plasma samples collected before vaccination, and after two doses of Rotarix® vaccination were tested for plasma rotavirus IgA titers.Two doses of Rotarix® provided to induce sero-protective titer of ≥ 20 Units in 35% of subjects. Total blood IgA- ASC responses were detected in 26.4% of subjects who were non-responder before vaccination. Among responders, 47% of the subjects also have sero-protective plasma IgA titers.Our results suggest that virus-specific blood gut homing ASCs were detected and provide insight into mucosal immune response after rotavirus vaccination. Further studies are needed to evaluate the duration of such immune responses and to assess the programmatic utility of this whole blood-based mucosal ASC testing for the rotavirus immunization program." @default.
- W2787016263 created "2018-02-23" @default.
- W2787016263 creator A5003996271 @default.
- W2787016263 creator A5004069171 @default.
- W2787016263 creator A5008799886 @default.
- W2787016263 creator A5011708446 @default.
- W2787016263 creator A5019766599 @default.
- W2787016263 creator A5020207892 @default.
- W2787016263 creator A5020869150 @default.
- W2787016263 creator A5028504628 @default.
- W2787016263 creator A5033554066 @default.
- W2787016263 creator A5039070711 @default.
- W2787016263 creator A5048479809 @default.
- W2787016263 creator A5050404191 @default.
- W2787016263 creator A5054724468 @default.
- W2787016263 creator A5057168573 @default.
- W2787016263 creator A5073387169 @default.
- W2787016263 creator A5083317153 @default.
- W2787016263 creator A5087299636 @default.
- W2787016263 creator A5089769333 @default.
- W2787016263 creator A5090967157 @default.
- W2787016263 date "2018-01-01" @default.
- W2787016263 modified "2023-10-07" @default.
- W2787016263 title "Antibody secreting B cells and plasma antibody response to rotavirus vaccination in infants from Kolkata India" @default.
- W2787016263 cites W148109975 @default.
- W2787016263 cites W1554174530 @default.
- W2787016263 cites W1706469309 @default.
- W2787016263 cites W1964571060 @default.
- W2787016263 cites W1967528793 @default.
- W2787016263 cites W1968017397 @default.
- W2787016263 cites W1975737434 @default.
- W2787016263 cites W1976169651 @default.
- W2787016263 cites W1982180773 @default.
- W2787016263 cites W1990582270 @default.
- W2787016263 cites W1995240012 @default.
- W2787016263 cites W2004498184 @default.
- W2787016263 cites W2011067501 @default.
- W2787016263 cites W2013938272 @default.
- W2787016263 cites W2020885045 @default.
- W2787016263 cites W2035934695 @default.
- W2787016263 cites W2051044510 @default.
- W2787016263 cites W2063884954 @default.
- W2787016263 cites W2066187043 @default.
- W2787016263 cites W2068583880 @default.
- W2787016263 cites W2070445709 @default.
- W2787016263 cites W2077035982 @default.
- W2787016263 cites W2078433912 @default.
- W2787016263 cites W2079206982 @default.
- W2787016263 cites W2081208246 @default.
- W2787016263 cites W2087156294 @default.
- W2787016263 cites W2096816070 @default.
- W2787016263 cites W2100178369 @default.
- W2787016263 cites W2101380815 @default.
- W2787016263 cites W2101610496 @default.
- W2787016263 cites W2103861589 @default.
- W2787016263 cites W2113014022 @default.
- W2787016263 cites W2134424755 @default.
- W2787016263 cites W2135985984 @default.
- W2787016263 cites W2148759300 @default.
- W2787016263 cites W2168555857 @default.
- W2787016263 cites W2169605506 @default.
- W2787016263 cites W2229518952 @default.
- W2787016263 cites W2299269284 @default.
- W2787016263 cites W2346899796 @default.
- W2787016263 cites W2402321912 @default.
- W2787016263 cites W2570756444 @default.
- W2787016263 cites W2065237221 @default.
- W2787016263 doi "https://doi.org/10.1016/j.heliyon.2018.e00519" @default.
- W2787016263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5857522" @default.
- W2787016263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29560435" @default.
- W2787016263 hasPublicationYear "2018" @default.
- W2787016263 type Work @default.
- W2787016263 sameAs 2787016263 @default.
- W2787016263 citedByCount "7" @default.
- W2787016263 countsByYear W27870162632019 @default.
- W2787016263 countsByYear W27870162632020 @default.
- W2787016263 countsByYear W27870162632021 @default.
- W2787016263 countsByYear W27870162632022 @default.
- W2787016263 crossrefType "journal-article" @default.
- W2787016263 hasAuthorship W2787016263A5003996271 @default.
- W2787016263 hasAuthorship W2787016263A5004069171 @default.
- W2787016263 hasAuthorship W2787016263A5008799886 @default.
- W2787016263 hasAuthorship W2787016263A5011708446 @default.
- W2787016263 hasAuthorship W2787016263A5019766599 @default.
- W2787016263 hasAuthorship W2787016263A5020207892 @default.
- W2787016263 hasAuthorship W2787016263A5020869150 @default.
- W2787016263 hasAuthorship W2787016263A5028504628 @default.
- W2787016263 hasAuthorship W2787016263A5033554066 @default.
- W2787016263 hasAuthorship W2787016263A5039070711 @default.
- W2787016263 hasAuthorship W2787016263A5048479809 @default.
- W2787016263 hasAuthorship W2787016263A5050404191 @default.
- W2787016263 hasAuthorship W2787016263A5054724468 @default.
- W2787016263 hasAuthorship W2787016263A5057168573 @default.
- W2787016263 hasAuthorship W2787016263A5073387169 @default.
- W2787016263 hasAuthorship W2787016263A5083317153 @default.
- W2787016263 hasAuthorship W2787016263A5087299636 @default.
- W2787016263 hasAuthorship W2787016263A5089769333 @default.
- W2787016263 hasAuthorship W2787016263A5090967157 @default.