FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2787134611> ?p ?o ?g. }

• W2787134611 endingPage "4859" @default.
• W2787134611 startingPage "4845" @default.
• W2787134611 abstract "The enzyme AICAR-transformylase/IMP cyclohydrolase (ATIC) catalyzes the last two steps of purine de novo synthesis. It metabolizes 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), which is an AMP analogue, leading to activation of AMP-activated kinase (AMPK). We investigated whether the AICAR–ATIC pathway plays a role in the high glucose (HG)–mediated DNA damage response and AICAR-mediated AMPK activation, explaining the detrimental effects of glucose on neuronal damage and shortening of the lifespan. HG up-regulated the expression and activity of the Caenorhabditis elegans homologue of ATIC, C55F2.1 (atic-1), and increased the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of atic-1 decreased the lifespan and head motility and increased neuronal damage under both standard and HG conditions. Inhibition of atic-1 expression, by RNAi, under HG was associated with increased lifespan and head motility and reduced neuronal damage, reactive oxygen species, and methylglyoxal-derived advanced glycation end product accumulation. This effect was independent of an effect on DNA damage or antioxidant defense pathways, such as superoxide dismutase (sod-3) or glyoxalase-1 (glod-4), but was dependent on AMPK and accumulation of AICAR. Through AMPK, AICAR treatment also reduced the negative effects of HG. The mitochondrial inhibitor rotenone abolished the AICAR/AMPK-induced amelioration of HG effects, pointing to mitochondria as a prime target of the glucotoxic effects in C. elegans. We conclude that atic-1 is involved in glucotoxic effects under HG conditions, either by blocked atic-1 expression or via AICAR and AMPK induction." @default.
• W2787134611 created "2018-02-23" @default.
• W2787134611 creator A5045061445 @default.
• W2787134611 creator A5046808397 @default.
• W2787134611 creator A5054170683 @default.
• W2787134611 creator A5056710976 @default.
• W2787134611 creator A5061127573 @default.
• W2787134611 creator A5067599146 @default.
• W2787134611 creator A5073008608 @default.
• W2787134611 creator A5081699544 @default.
• W2787134611 date "2018-03-01" @default.
• W2787134611 modified "2023-10-16" @default.
• W2787134611 title "High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans" @default.
• W2787134611 cites W1489995256 @default.
• W2787134611 cites W1545181609 @default.
• W2787134611 cites W1964343416 @default.
• W2787134611 cites W1968054800 @default.
• W2787134611 cites W1974669825 @default.
• W2787134611 cites W1985630965 @default.
• W2787134611 cites W1994041994 @default.
• W2787134611 cites W1994266514 @default.
• W2787134611 cites W1996280803 @default.
• W2787134611 cites W2004089120 @default.
• W2787134611 cites W2011735401 @default.
• W2787134611 cites W2021786783 @default.
• W2787134611 cites W2027977649 @default.
• W2787134611 cites W2028097286 @default.
• W2787134611 cites W2028608245 @default.
• W2787134611 cites W2030636484 @default.
• W2787134611 cites W2031146914 @default.
• W2787134611 cites W2032481571 @default.
• W2787134611 cites W2033524679 @default.
• W2787134611 cites W2037180034 @default.
• W2787134611 cites W2038227076 @default.
• W2787134611 cites W2043406394 @default.
• W2787134611 cites W2045364112 @default.
• W2787134611 cites W2056673369 @default.
• W2787134611 cites W2057218469 @default.
• W2787134611 cites W2064225393 @default.
• W2787134611 cites W2082603625 @default.
• W2787134611 cites W2084536221 @default.
• W2787134611 cites W2087136121 @default.
• W2787134611 cites W2087491465 @default.
• W2787134611 cites W2091944089 @default.
• W2787134611 cites W2103628478 @default.
• W2787134611 cites W2110174113 @default.
• W2787134611 cites W2114339108 @default.
• W2787134611 cites W2118890024 @default.
• W2787134611 cites W2119646657 @default.
• W2787134611 cites W2120936083 @default.
• W2787134611 cites W2122163057 @default.
• W2787134611 cites W2128588786 @default.
• W2787134611 cites W2131739290 @default.
• W2787134611 cites W2141340790 @default.
• W2787134611 cites W2142305917 @default.
• W2787134611 cites W2145257045 @default.
• W2787134611 cites W2155465717 @default.
• W2787134611 cites W2163863334 @default.
• W2787134611 cites W2203561322 @default.
• W2787134611 cites W2266349963 @default.
• W2787134611 cites W2319363430 @default.
• W2787134611 cites W2461456259 @default.
• W2787134611 cites W2474510403 @default.
• W2787134611 cites W2508351200 @default.
• W2787134611 cites W2529578415 @default.
• W2787134611 doi "https://doi.org/10.1074/jbc.m117.805879" @default.
• W2787134611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5880143" @default.
• W2787134611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29414769" @default.
• W2787134611 hasPublicationYear "2018" @default.
• W2787134611 type Work @default.
• W2787134611 sameAs 2787134611 @default.
• W2787134611 citedByCount "5" @default.
• W2787134611 countsByYear W27871346112019 @default.
• W2787134611 countsByYear W27871346112020 @default.
• W2787134611 countsByYear W27871346112022 @default.
• W2787134611 crossrefType "journal-article" @default.
• W2787134611 hasAuthorship W2787134611A5045061445 @default.
• W2787134611 hasAuthorship W2787134611A5046808397 @default.
• W2787134611 hasAuthorship W2787134611A5054170683 @default.
• W2787134611 hasAuthorship W2787134611A5056710976 @default.
• W2787134611 hasAuthorship W2787134611A5061127573 @default.
• W2787134611 hasAuthorship W2787134611A5067599146 @default.
• W2787134611 hasAuthorship W2787134611A5073008608 @default.
• W2787134611 hasAuthorship W2787134611A5081699544 @default.
• W2787134611 hasBestOaLocation W27871346111 @default.
• W2787134611 hasConcept C104317684 @default.
• W2787134611 hasConcept C178790620 @default.
• W2787134611 hasConcept C184235292 @default.
• W2787134611 hasConcept C185592680 @default.
• W2787134611 hasConcept C2776780712 @default.
• W2787134611 hasConcept C2778944004 @default.
• W2787134611 hasConcept C2780124434 @default.
• W2787134611 hasConcept C29730261 @default.
• W2787134611 hasConcept C55493867 @default.
• W2787134611 hasConcept C86803240 @default.
• W2787134611 hasConcept C95444343 @default.
• W2787134611 hasConcept C97029542 @default.
• W2787134611 hasConceptScore W2787134611C104317684 @default.

• next