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• W2787191607 abstract "Abstract Circoviruses (family Circoviridae ) are small, non-enveloped viruses that have short, single-stranded DNA genomes. Circovirus sequences are frequently recovered in metagenomic investigations, indicating that these viruses are widespread, yet they remain relatively poorly understood. Endogenous circoviral elements (CVe) are DNA sequences derived from circoviruses that occur in vertebrate genomes. CVe can provide unique, retrospective information about the biology and evolution of circoviruses. In this study, we screened 362 vertebrate genome assemblies in silico to generate a catalog of CVe loci. We identified a total of 179 CVe sequences, most of which have not been reported previously. We show that these CVe loci reflect at least 19 distinct germline integration events. We determine the structure of CVe loci, identifying some that show evidence of potential functionalization. We also identify orthologous copies of CVe in snakes, fish, birds, and mammals, allowing us to add new calibrations to the timeline of circovirus evolution. Finally, we observed that some ancient CVe group robustly with contemporary circoviruses in phylogenies, with all sequences within these groups being derived from the same host class or order, implying a hitherto underappreciated stability in circovirus-host relationships. The openly available dataset constructed in this investigation provides new insights into circovirus evolution, and can be used to facilitate further studies of circoviruses and CVe. Abbreviations CVe endogenous circoviral element ORF open reading frame Cap Capsid Rep Replicase ssDNA single-stranded DNA" @default.
• W2787191607 created "2018-02-23" @default.
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• W2787191607 date "2018-01-16" @default.
• W2787191607 modified "2023-10-01" @default.
• W2787191607 title "The evolution, distribution and diversity and of endogenous circoviral elements" @default.
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• W2787191607 doi "https://doi.org/10.1101/207399" @default.
• W2787191607 hasPublicationYear "2018" @default.
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