FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2787244801> ?p ?o ?g. }

• W2787244801 abstract "Systems Biology pose computational challenges that surpass the capabilities of current computing platforms. A particular challenge in this regard is simulating the dynamics of Gene Regulatory Networks (GRNs). This is because the number of possible network states, and thus the time required to compute them, grows exponentially with the number of network components. FPGA-based accelerators appear as promising alternatives to simulations on conventional software platforms. However, their application in the dynamic simulation of GRNs has been hindered by the inaccessibility of this technology to users without the proper expertise. Heterogeneous CPU-FPGA computing platforms, combined with high-level, flexible tools to deploy FPGA implementations, represent a powerful avenue to open the benefits of hardware acceleration to biologists. We present a high-level framework that exploits such acceleration for the simulation of GRNs, without compromising flexibility. Our tool takes as an input a biological network description in a standard format and translates it into a Verilog module. This module is subsequently incorporated into a hardware design optimized for the simulation of the network dynamics. To demonstrate the potential of our methodology, we simulated the dynamics of two large-scale GRNs, one involved in tumor formation in Colitis-Associated Colon cancer consisting of 70 nodes, and the other describing the signaling pathways of a lymphocyte cell comprised of 188 nodes. Our approach simulates the dynamics of the networks up to two orders of magnitude faster than an optimized OpenMP implementation on a multicore CPU." @default.
• W2787244801 created "2018-02-23" @default.
• W2787244801 creator A5005007426 @default.
• W2787244801 creator A5014491106 @default.
• W2787244801 creator A5016370549 @default.
• W2787244801 creator A5036640919 @default.
• W2787244801 creator A5050648001 @default.
• W2787244801 creator A5068177643 @default.
• W2787244801 date "2017-12-01" @default.
• W2787244801 modified "2023-09-27" @default.
• W2787244801 title "Exploring the dynamics of large-scale gene regulatory networks using hardware acceleration on a heterogeneous CPU-FPGA platform" @default.
• W2787244801 cites W1830972360 @default.
• W2787244801 cites W1976735018 @default.
• W2787244801 cites W1981898075 @default.
• W2787244801 cites W1994575730 @default.
• W2787244801 cites W2017641680 @default.
• W2787244801 cites W2018519939 @default.
• W2787244801 cites W2040694642 @default.
• W2787244801 cites W2052252977 @default.
• W2787244801 cites W2056486314 @default.
• W2787244801 cites W2069125012 @default.
• W2787244801 cites W2070040687 @default.
• W2787244801 cites W2072890688 @default.
• W2787244801 cites W2109884611 @default.
• W2787244801 cites W2119530812 @default.
• W2787244801 cites W2120947607 @default.
• W2787244801 cites W2122902176 @default.
• W2787244801 cites W2123998089 @default.
• W2787244801 cites W2127899308 @default.
• W2787244801 cites W2128085946 @default.
• W2787244801 cites W2138228997 @default.
• W2787244801 cites W2150908245 @default.
• W2787244801 cites W2155142785 @default.
• W2787244801 cites W2166214692 @default.
• W2787244801 cites W2405102949 @default.
• W2787244801 cites W2576119444 @default.
• W2787244801 cites W2732466471 @default.
• W2787244801 doi "https://doi.org/10.1109/reconfig.2017.8279791" @default.
• W2787244801 hasPublicationYear "2017" @default.
• W2787244801 type Work @default.
• W2787244801 sameAs 2787244801 @default.
• W2787244801 citedByCount "6" @default.
• W2787244801 countsByYear W27872448012018 @default.
• W2787244801 countsByYear W27872448012020 @default.
• W2787244801 countsByYear W27872448012021 @default.
• W2787244801 crossrefType "proceedings-article" @default.
• W2787244801 hasAuthorship W2787244801A5005007426 @default.
• W2787244801 hasAuthorship W2787244801A5014491106 @default.
• W2787244801 hasAuthorship W2787244801A5016370549 @default.
• W2787244801 hasAuthorship W2787244801A5036640919 @default.
• W2787244801 hasAuthorship W2787244801A5050648001 @default.
• W2787244801 hasAuthorship W2787244801A5068177643 @default.
• W2787244801 hasConcept C105795698 @default.
• W2787244801 hasConcept C111919701 @default.
• W2787244801 hasConcept C117896860 @default.
• W2787244801 hasConcept C118524514 @default.
• W2787244801 hasConcept C120314980 @default.
• W2787244801 hasConcept C121332964 @default.
• W2787244801 hasConcept C13164978 @default.
• W2787244801 hasConcept C149635348 @default.
• W2787244801 hasConcept C173608175 @default.
• W2787244801 hasConcept C199360897 @default.
• W2787244801 hasConcept C26713055 @default.
• W2787244801 hasConcept C2777904410 @default.
• W2787244801 hasConcept C2779030575 @default.
• W2787244801 hasConcept C2780598303 @default.
• W2787244801 hasConcept C33923547 @default.
• W2787244801 hasConcept C41008148 @default.
• W2787244801 hasConcept C42935608 @default.
• W2787244801 hasConcept C74650414 @default.
• W2787244801 hasConcept C78766204 @default.
• W2787244801 hasConceptScore W2787244801C105795698 @default.
• W2787244801 hasConceptScore W2787244801C111919701 @default.
• W2787244801 hasConceptScore W2787244801C117896860 @default.
• W2787244801 hasConceptScore W2787244801C118524514 @default.
• W2787244801 hasConceptScore W2787244801C120314980 @default.
• W2787244801 hasConceptScore W2787244801C121332964 @default.
• W2787244801 hasConceptScore W2787244801C13164978 @default.
• W2787244801 hasConceptScore W2787244801C149635348 @default.
• W2787244801 hasConceptScore W2787244801C173608175 @default.
• W2787244801 hasConceptScore W2787244801C199360897 @default.
• W2787244801 hasConceptScore W2787244801C26713055 @default.
• W2787244801 hasConceptScore W2787244801C2777904410 @default.
• W2787244801 hasConceptScore W2787244801C2779030575 @default.
• W2787244801 hasConceptScore W2787244801C2780598303 @default.
• W2787244801 hasConceptScore W2787244801C33923547 @default.
• W2787244801 hasConceptScore W2787244801C41008148 @default.
• W2787244801 hasConceptScore W2787244801C42935608 @default.
• W2787244801 hasConceptScore W2787244801C74650414 @default.
• W2787244801 hasConceptScore W2787244801C78766204 @default.
• W2787244801 hasLocation W27872448011 @default.
• W2787244801 hasOpenAccess W2787244801 @default.
• W2787244801 hasPrimaryLocation W27872448011 @default.
• W2787244801 hasRelatedWork W1566136542 @default.
• W2787244801 hasRelatedWork W1732210391 @default.
• W2787244801 hasRelatedWork W1761969858 @default.
• W2787244801 hasRelatedWork W2058005004 @default.
• W2787244801 hasRelatedWork W2097399821 @default.
• W2787244801 hasRelatedWork W2488897859 @default.
• W2787244801 hasRelatedWork W2793542907 @default.

• next