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- W2787244821 abstract "AIM AND OBJECTIVES: The present study Phytochemical evaluation of the whole plant of ethanolic extract of Portulaca quadrifida L. To determine the glucose diffusion property of the prepared extract of the Portulacaquadrifida L. using dialysis tube and GOD-POD kit. To evaluate the safety of the effective extract of Portulaca quadrifida L. by acute toxicitystudy in Wistar albino rats.To investigate the in-vivo anti diabetic effect of active extract of Portulaca quadrifida L.in Streptozotocin induced diabetic Wistar albino rats. In our studies, the damage of pancreas in STZ treated diabetic control (Figure17) andregeneration of β-cells by Glibenclamide (Figure16) was observed. The regeneration inethanolic extract of Portulaca quadrifida L. was comparable with Glibenclamide; Portulacaquadrifida L. extract (400mg/kg) was showed better regeneration than (200mg/kg) ofPortulaca quadrifida L. extract.Photomicrographical data in our studies reinforce healing of pancreas by ethanolicextract of 200mg/kg and 400mg/kg as a plausible mechanism of their antidiabetic activity.The data of our studies suggests that Portulaca quadrifida L. has beneficial effects indiabetes mellitus holding the hope of a new generation for anti-diabetic drugs. CONCLUSION: From the present study we conclude that the preliminary phytochemical analysis ofPortulaca quadrifida L. indicated the presence of alkaloids, flavonoids, proteins,saponins, carbohydrates, terpenoids, mucilage, glycosides, tannins and phytosterols.Invitro Glucose adsorption assay of Portulaca quadrifida L. extract was evaluatedusing GOD-POD kit.Invitro Glucose diffusion properties of Portulaca quadrifida L. extract was evaluatedusing dialysis membrane and GOD-POD kit.Ethanolic extract of Portulaca quadrifida L. was safe in dose upto 2000mg/kg byacute toxicity study and there was no toxic effects produced.The ethanolic extract of Portulaca quadrifida L. exhibited significant antidiabeticactivity in Streptozotocin induced diabetic rats.In vivo studies of Portulaca quadrifida L. ethanolic extract revealed the glucoselowering effect& improved activity of carbohydrate metabolizing enzymes. Thus itwas concluded that the ethanolic extract of Portulaca quadrifida L. has anti-diabeticactivity." @default.
- W2787244821 created "2018-02-23" @default.
- W2787244821 creator A5076456919 @default.
- W2787244821 date "2014-04-01" @default.
- W2787244821 modified "2023-09-26" @default.
- W2787244821 title "Evaluation of Invitro And Invivo Anti Diabetic Activity of Ethanolic Extract of Portulaca Quadrifida L. on Streptozotocin Induced Diabetes in Rats." @default.
- W2787244821 hasPublicationYear "2014" @default.
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