Matches in SemOpenAlex for { <https://semopenalex.org/work/W2787440058> ?p ?o ?g. }
- W2787440058 abstract "Crohn’s disease (CD) is a chronic inflammatory disease of the gastrointestinal tract (GIT). Cigarette smoke (CS) exposure and chronic obstructive pulmonary disease (COPD) are risk factors for CD, although the mechanisms involved are poorly understood. We employed a mouse model of CS-induced experimental COPD and clinical studies to examine these mechanisms. Concurrent with the development of pulmonary pathology and impaired gas exchange, CS-exposed mice developed CD-associated pathology in the colon and ileum, including gut mucosal tissue hypoxia, HIF-2 stabilization, inflammation, increased microvasculature, epithelial cell turnover, and decreased intestinal barrier function. Subsequent smoking cessation reduced GIT pathology, particularly in the ileum. Dimethyloxaloylglycine, a pan-prolyl hydroxylase inhibitor, ameliorated CS-induced GIT pathology independently of pulmonary pathology. Prior smoke exposure exacerbated intestinal pathology in 2,4,6-trinitrobenzenesulfonic acid–induced (TNBS-induced) colitis. Circulating vascular endothelial growth factor, a marker of systemic hypoxia, correlated with CS exposure and CD in mice and humans. Increased mucosal vascularisation was evident in ileum biopsies from CD patients who smoke compared with nonsmokers, supporting our preclinical data. We provide strong evidence that chronic CS exposure and, for the first time to our knowledge, associated impaired gas exchange cause systemic and intestinal ischemia, driving angiogenesis and GIT epithelial barrier dysfunction, resulting in increased risk and severity of CD." @default.
- W2787440058 created "2018-02-23" @default.
- W2787440058 creator A5009041563 @default.
- W2787440058 creator A5018605111 @default.
- W2787440058 creator A5020598405 @default.
- W2787440058 creator A5026626784 @default.
- W2787440058 creator A5029245116 @default.
- W2787440058 creator A5031167477 @default.
- W2787440058 creator A5034890420 @default.
- W2787440058 creator A5058711635 @default.
- W2787440058 creator A5059369253 @default.
- W2787440058 creator A5063808743 @default.
- W2787440058 creator A5064708356 @default.
- W2787440058 creator A5072697342 @default.
- W2787440058 creator A5074742233 @default.
- W2787440058 creator A5076048446 @default.
- W2787440058 date "2018-02-08" @default.
- W2787440058 modified "2023-10-10" @default.
- W2787440058 title "Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction" @default.
- W2787440058 cites W1488452840 @default.
- W2787440058 cites W1488835155 @default.
- W2787440058 cites W1567135569 @default.
- W2787440058 cites W1597336200 @default.
- W2787440058 cites W1627839739 @default.
- W2787440058 cites W185211972 @default.
- W2787440058 cites W1865841947 @default.
- W2787440058 cites W1963571350 @default.
- W2787440058 cites W1967651790 @default.
- W2787440058 cites W1970837893 @default.
- W2787440058 cites W1976041167 @default.
- W2787440058 cites W1978505763 @default.
- W2787440058 cites W1992525727 @default.
- W2787440058 cites W1995538416 @default.
- W2787440058 cites W1999522012 @default.
- W2787440058 cites W2004053427 @default.
- W2787440058 cites W2005539293 @default.
- W2787440058 cites W2009710456 @default.
- W2787440058 cites W2012191694 @default.
- W2787440058 cites W2014562678 @default.
- W2787440058 cites W2015907680 @default.
- W2787440058 cites W2019496443 @default.
- W2787440058 cites W2019797753 @default.
- W2787440058 cites W2021835206 @default.
- W2787440058 cites W2024346860 @default.
- W2787440058 cites W2030479855 @default.
- W2787440058 cites W2031620810 @default.
- W2787440058 cites W2031832348 @default.
- W2787440058 cites W2032370476 @default.
- W2787440058 cites W2039630990 @default.
- W2787440058 cites W2042378494 @default.
- W2787440058 cites W2042939284 @default.
- W2787440058 cites W2050723471 @default.
- W2787440058 cites W2051068640 @default.
- W2787440058 cites W2056425530 @default.
- W2787440058 cites W2060189000 @default.
- W2787440058 cites W2069501078 @default.
- W2787440058 cites W2069513082 @default.
- W2787440058 cites W2071825506 @default.
- W2787440058 cites W2088650457 @default.
- W2787440058 cites W2093607179 @default.
- W2787440058 cites W2094294562 @default.
- W2787440058 cites W2096719505 @default.
- W2787440058 cites W2097979070 @default.
- W2787440058 cites W2098087741 @default.
- W2787440058 cites W2099975088 @default.
- W2787440058 cites W2101787773 @default.
- W2787440058 cites W2102764783 @default.
- W2787440058 cites W2103038852 @default.
- W2787440058 cites W2111839917 @default.
- W2787440058 cites W2114023059 @default.
- W2787440058 cites W2114214481 @default.
- W2787440058 cites W2118427816 @default.
- W2787440058 cites W2125065061 @default.
- W2787440058 cites W2126885582 @default.
- W2787440058 cites W2127413321 @default.
- W2787440058 cites W2133938746 @default.
- W2787440058 cites W2136344183 @default.
- W2787440058 cites W2139239087 @default.
- W2787440058 cites W2140731876 @default.
- W2787440058 cites W2142321394 @default.
- W2787440058 cites W2149111749 @default.
- W2787440058 cites W2151851977 @default.
- W2787440058 cites W2156061040 @default.
- W2787440058 cites W2158507525 @default.
- W2787440058 cites W2162133321 @default.
- W2787440058 cites W2162217523 @default.
- W2787440058 cites W2163704839 @default.
- W2787440058 cites W2168873819 @default.
- W2787440058 cites W2170099630 @default.
- W2787440058 cites W2182578492 @default.
- W2787440058 cites W2195217061 @default.
- W2787440058 cites W2224201356 @default.
- W2787440058 cites W2272764162 @default.
- W2787440058 cites W2297582208 @default.
- W2787440058 cites W2415167936 @default.
- W2787440058 cites W2439973029 @default.
- W2787440058 cites W2528396364 @default.
- W2787440058 cites W4385890405 @default.
- W2787440058 cites W2594842159 @default.
- W2787440058 doi "https://doi.org/10.1172/jci.insight.94040" @default.