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- W2787503105 abstract "The nematode Caenorhabditis elegans, with tractable genetics and a well-defined nervous system, provides a unique whole-animal model system to identify novel drug targets and therapies for neurodegenerative diseases. Large-scale drug or target screens in models that recapitulate the subtle age- and cell-specific aspects of neurodegenerative diseases are limited by a technological requirement for high-throughput analysis of neuronal morphology. Recently, we developed a single-copy model of amyloid precursor protein (SC_APP) induced neurodegeneration that exhibits progressive degeneration of select cholinergic neurons. Our previous work with this model suggests that small molecule ligands of the sigma 2 receptor (σ2R), which was recently cloned and identified as transmembrane protein 97 (TMEM97), are neuroprotective. To determine structure–activity relationships for unexplored chemical space in our σ2R/Tmem97 ligand collection, we developed an in vivo high-content screening (HCS) assay to identify potential drug leads. The HCS assay uses our recently developed large-scale microfluidic immobilization chip and automated imaging platform. We discovered norbenzomorphans that reduced neurodegeneration in our C. elegans model, including two compounds that demonstrated significant neuroprotective activity at multiple doses. These findings provide further evidence that σ2R/Tmem97-binding norbenzomorphans may represent a new drug class for treating neurodegenerative diseases." @default.
- W2787503105 created "2018-02-23" @default.
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- W2787503105 date "2018-02-09" @default.
- W2787503105 modified "2023-10-16" @default.
- W2787503105 title "High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in <i>C. elegans</i> SC_APP Model" @default.
- W2787503105 cites W1523583251 @default.
- W2787503105 cites W1602771322 @default.
- W2787503105 cites W1612484725 @default.
- W2787503105 cites W1652342837 @default.
- W2787503105 cites W1944127002 @default.
- W2787503105 cites W1966622401 @default.
- W2787503105 cites W1971409228 @default.
- W2787503105 cites W1974206195 @default.
- W2787503105 cites W1975595547 @default.
- W2787503105 cites W1981964968 @default.
- W2787503105 cites W1987779095 @default.
- W2787503105 cites W1991001144 @default.
- W2787503105 cites W1991571916 @default.
- W2787503105 cites W1993366467 @default.
- W2787503105 cites W1996054899 @default.
- W2787503105 cites W2008752021 @default.
- W2787503105 cites W2018358250 @default.
- W2787503105 cites W2022313872 @default.
- W2787503105 cites W2032032613 @default.
- W2787503105 cites W2034475831 @default.
- W2787503105 cites W2041778047 @default.
- W2787503105 cites W2041915519 @default.
- W2787503105 cites W2042158211 @default.
- W2787503105 cites W2051629075 @default.
- W2787503105 cites W2052574615 @default.
- W2787503105 cites W2057119740 @default.
- W2787503105 cites W2057805987 @default.
- W2787503105 cites W2060972405 @default.
- W2787503105 cites W2062495736 @default.
- W2787503105 cites W2063967205 @default.
- W2787503105 cites W2065113491 @default.
- W2787503105 cites W2067557638 @default.
- W2787503105 cites W2076628540 @default.
- W2787503105 cites W2079458003 @default.
- W2787503105 cites W2080612234 @default.
- W2787503105 cites W2081388499 @default.
- W2787503105 cites W2084253896 @default.
- W2787503105 cites W2089351812 @default.
- W2787503105 cites W2093301541 @default.
- W2787503105 cites W2096230200 @default.
- W2787503105 cites W2097636413 @default.
- W2787503105 cites W2101372957 @default.
- W2787503105 cites W2103147849 @default.
- W2787503105 cites W2104177210 @default.
- W2787503105 cites W2104214286 @default.
- W2787503105 cites W2107979600 @default.
- W2787503105 cites W2116450149 @default.
- W2787503105 cites W2118906274 @default.
- W2787503105 cites W2121445258 @default.
- W2787503105 cites W2129891016 @default.
- W2787503105 cites W2132162535 @default.
- W2787503105 cites W2137431200 @default.
- W2787503105 cites W2155395152 @default.
- W2787503105 cites W2162424201 @default.
- W2787503105 cites W2162617494 @default.
- W2787503105 cites W2165462380 @default.
- W2787503105 cites W2168112956 @default.
- W2787503105 cites W2168130410 @default.
- W2787503105 cites W2169988628 @default.
- W2787503105 cites W2171545955 @default.
- W2787503105 cites W2252431628 @default.
- W2787503105 cites W2282510442 @default.
- W2787503105 cites W2423217937 @default.
- W2787503105 cites W2471059767 @default.
- W2787503105 cites W2529741867 @default.
- W2787503105 cites W2530040823 @default.
- W2787503105 cites W2560084727 @default.
- W2787503105 cites W2564232696 @default.
- W2787503105 cites W2597717383 @default.
- W2787503105 cites W2606022362 @default.
- W2787503105 cites W2618221287 @default.
- W2787503105 cites W2669040921 @default.
- W2787503105 cites W2750058540 @default.
- W2787503105 cites W2949075279 @default.
- W2787503105 cites W2949785376 @default.
- W2787503105 cites W3145943915 @default.
- W2787503105 cites W3150015993 @default.
- W2787503105 cites W4230501579 @default.
- W2787503105 doi "https://doi.org/10.1021/acschemneuro.7b00428" @default.