FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2787649310> ?p ?o ?g. }

• W2787649310 endingPage "228.e4" @default.
• W2787649310 startingPage "217" @default.
• W2787649310 abstract "A quarter of all solid tumors harbor KRAS oncogenes. Yet, no selective drugs have been approved to treat these malignancies. Genetic interrogation of the MAPK pathway revealed that systemic ablation of MEK or ERK kinases in adult mice prevent tumor development but are unacceptably toxic. Here, we demonstrate that ablation of c-RAF expression in advanced tumors driven by KrasG12V/Trp53 mutations leads to significant tumor regression with no detectable appearance of resistance mechanisms. Tumor regression results from massive apoptosis. Importantly, systemic abrogation of c-RAF expression does not inhibit canonical MAPK signaling, hence, resulting in limited toxicities. These results are of significant relevance for the design of therapeutic strategies to treat K-RAS mutant cancers." @default.
• W2787649310 created "2018-02-23" @default.
• W2787649310 creator A5021741282 @default.
• W2787649310 creator A5030492647 @default.
• W2787649310 creator A5037397985 @default.
• W2787649310 creator A5045234163 @default.
• W2787649310 creator A5056668478 @default.
• W2787649310 creator A5060524747 @default.
• W2787649310 creator A5060552258 @default.
• W2787649310 creator A5082250124 @default.
• W2787649310 creator A5086660695 @default.
• W2787649310 creator A5086739924 @default.
• W2787649310 creator A5088954118 @default.
• W2787649310 date "2018-02-01" @default.
• W2787649310 modified "2023-10-18" @default.
• W2787649310 title "c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling" @default.
• W2787649310 cites W1965343041 @default.
• W2787649310 cites W1966725512 @default.
• W2787649310 cites W1977431691 @default.
• W2787649310 cites W1980010067 @default.
• W2787649310 cites W1981851742 @default.
• W2787649310 cites W1989734503 @default.
• W2787649310 cites W2000581759 @default.
• W2787649310 cites W2032019019 @default.
• W2787649310 cites W2041098455 @default.
• W2787649310 cites W2041687747 @default.
• W2787649310 cites W2047401805 @default.
• W2787649310 cites W2050573392 @default.
• W2787649310 cites W2075234503 @default.
• W2787649310 cites W2077297619 @default.
• W2787649310 cites W2078212397 @default.
• W2787649310 cites W2079895289 @default.
• W2787649310 cites W2081990599 @default.
• W2787649310 cites W2085736853 @default.
• W2787649310 cites W2107079238 @default.
• W2787649310 cites W2125703895 @default.
• W2787649310 cites W2128059000 @default.
• W2787649310 cites W2128339707 @default.
• W2787649310 cites W2133177414 @default.
• W2787649310 cites W2137715268 @default.
• W2787649310 cites W2144708319 @default.
• W2787649310 cites W2149281736 @default.
• W2787649310 cites W2168057727 @default.
• W2787649310 cites W2619996349 @default.
• W2787649310 doi "https://doi.org/10.1016/j.ccell.2017.12.014" @default.
• W2787649310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29395869" @default.
• W2787649310 hasPublicationYear "2018" @default.
• W2787649310 type Work @default.
• W2787649310 sameAs 2787649310 @default.
• W2787649310 citedByCount "81" @default.
• W2787649310 countsByYear W27876493102018 @default.
• W2787649310 countsByYear W27876493102019 @default.
• W2787649310 countsByYear W27876493102020 @default.
• W2787649310 countsByYear W27876493102021 @default.
• W2787649310 countsByYear W27876493102022 @default.
• W2787649310 countsByYear W27876493102023 @default.
• W2787649310 crossrefType "journal-article" @default.
• W2787649310 hasAuthorship W2787649310A5021741282 @default.
• W2787649310 hasAuthorship W2787649310A5030492647 @default.
• W2787649310 hasAuthorship W2787649310A5037397985 @default.
• W2787649310 hasAuthorship W2787649310A5045234163 @default.
• W2787649310 hasAuthorship W2787649310A5056668478 @default.
• W2787649310 hasAuthorship W2787649310A5060524747 @default.
• W2787649310 hasAuthorship W2787649310A5060552258 @default.
• W2787649310 hasAuthorship W2787649310A5082250124 @default.
• W2787649310 hasAuthorship W2787649310A5086660695 @default.
• W2787649310 hasAuthorship W2787649310A5086739924 @default.
• W2787649310 hasAuthorship W2787649310A5088954118 @default.
• W2787649310 hasBestOaLocation W27876493101 @default.
• W2787649310 hasConcept C104317684 @default.
• W2787649310 hasConcept C121608353 @default.
• W2787649310 hasConcept C126322002 @default.
• W2787649310 hasConcept C143065580 @default.
• W2787649310 hasConcept C143998085 @default.
• W2787649310 hasConcept C184235292 @default.
• W2787649310 hasConcept C190283241 @default.
• W2787649310 hasConcept C2776256026 @default.
• W2787649310 hasConcept C2781187634 @default.
• W2787649310 hasConcept C502942594 @default.
• W2787649310 hasConcept C526805850 @default.
• W2787649310 hasConcept C54355233 @default.
• W2787649310 hasConcept C57074206 @default.
• W2787649310 hasConcept C62478195 @default.
• W2787649310 hasConcept C71924100 @default.
• W2787649310 hasConcept C86803240 @default.
• W2787649310 hasConcept C95444343 @default.
• W2787649310 hasConceptScore W2787649310C104317684 @default.
• W2787649310 hasConceptScore W2787649310C121608353 @default.
• W2787649310 hasConceptScore W2787649310C126322002 @default.
• W2787649310 hasConceptScore W2787649310C143065580 @default.
• W2787649310 hasConceptScore W2787649310C143998085 @default.
• W2787649310 hasConceptScore W2787649310C184235292 @default.
• W2787649310 hasConceptScore W2787649310C190283241 @default.
• W2787649310 hasConceptScore W2787649310C2776256026 @default.
• W2787649310 hasConceptScore W2787649310C2781187634 @default.
• W2787649310 hasConceptScore W2787649310C502942594 @default.
• W2787649310 hasConceptScore W2787649310C526805850 @default.
• W2787649310 hasConceptScore W2787649310C54355233 @default.

• next