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- W2787662649 endingPage "641" @default.
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- W2787662649 abstract "Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially derived metabolites. Functionally, they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of such metabolites and which are presented on MR1. Viruses cannot generate these ligands, so a priori, they should not be recognized by MAIT cells and indeed this is true when considering recognition through the TCR. However, MAIT cells are distinctive in another respect, since they respond quite sensitively to non-TCR signals, especially in the form of inflammatory cytokines. Thus, a number of groups have shown that virus infection can be sensed by MAIT cells and a functional response invoked. Since MAIT cells are abundant in humans, especially in tissues such as the liver, the question has arisen as to whether this TCR-independent MAIT cell triggering by viruses plays any role in vivo. In this review, we will discuss the evidence for this phenomenon and some common features which emerge across different recent studies in this area." @default.
- W2787662649 created "2018-02-23" @default.
- W2787662649 creator A5008719831 @default.
- W2787662649 creator A5029546143 @default.
- W2787662649 creator A5048797559 @default.
- W2787662649 date "2018-02-10" @default.
- W2787662649 modified "2023-10-15" @default.
- W2787662649 title "MAIT cells and viruses" @default.
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- W2787662649 doi "https://doi.org/10.1111/imcb.12008" @default.
- W2787662649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6055725" @default.
- W2787662649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29350807" @default.
- W2787662649 hasPublicationYear "2018" @default.
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