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- W2787700854 endingPage "295" @default.
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- W2787700854 abstract "Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity." @default.
- W2787700854 created "2018-02-23" @default.
- W2787700854 creator A5006376956 @default.
- W2787700854 creator A5019826825 @default.
- W2787700854 creator A5047165457 @default.
- W2787700854 creator A5080855793 @default.
- W2787700854 date "2018-04-01" @default.
- W2787700854 modified "2023-10-15" @default.
- W2787700854 title "Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion" @default.
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