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- W2787777580 endingPage "603" @default.
- W2787777580 startingPage "587" @default.
- W2787777580 abstract "Toll-like receptors (TLRs) are vital elements of the mammalian immune system that function by recognizing pathogen-associated molecular patterns (PAMPs), bridging innate and adaptive immunity. They have become a prominent therapeutic target for the treatment of infectious diseases, cancer, and allergies, with many TLR agonists currently in clinical trials or approved as immunostimulants. Numerous studies have shown that conjugation of TLR agonists to other molecules can beneficially influence their potency, toxicity, pharmacokinetics, or function. The functional properties of TLR agonist conjugates, however, are highly dependent on the ligation strategy employed. Here, we review the chemical structural requirements for effective functional TLR agonist conjugation. In addition, we provide similar analysis for those that have yet to be conjugated. Moreover, we discuss applications of covalent TLR agonist conjugation and their implications for clinical use." @default.
- W2787777580 created "2018-02-23" @default.
- W2787777580 creator A5003559845 @default.
- W2787777580 creator A5008005518 @default.
- W2787777580 creator A5018551147 @default.
- W2787777580 creator A5081525672 @default.
- W2787777580 date "2018-01-29" @default.
- W2787777580 modified "2023-10-16" @default.
- W2787777580 title "Toll-like Receptor Agonist Conjugation: A Chemical Perspective" @default.
- W2787777580 cites W1477040092 @default.
- W2787777580 cites W1486895457 @default.
- W2787777580 cites W1498597320 @default.
- W2787777580 cites W1513161963 @default.
- W2787777580 cites W1557759563 @default.
- W2787777580 cites W1565354283 @default.
- W2787777580 cites W1592581217 @default.
- W2787777580 cites W1664413187 @default.
- W2787777580 cites W1892962033 @default.
- W2787777580 cites W1895112319 @default.
- W2787777580 cites W1938018762 @default.
- W2787777580 cites W1959134931 @default.
- W2787777580 cites W1969072247 @default.
- W2787777580 cites W1969354039 @default.
- W2787777580 cites W1969447989 @default.
- W2787777580 cites W1970536207 @default.
- W2787777580 cites W1971353492 @default.
- W2787777580 cites W1980775088 @default.
- W2787777580 cites W1981399181 @default.
- W2787777580 cites W1981488330 @default.
- W2787777580 cites W1985477675 @default.
- W2787777580 cites W1986042071 @default.
- W2787777580 cites W1988097468 @default.
- W2787777580 cites W1989918485 @default.
- W2787777580 cites W1990898984 @default.
- W2787777580 cites W1991083095 @default.
- W2787777580 cites W1991287897 @default.
- W2787777580 cites W1995586746 @default.
- W2787777580 cites W1995744610 @default.
- W2787777580 cites W1997839876 @default.
- W2787777580 cites W1997920823 @default.
- W2787777580 cites W1998631096 @default.
- W2787777580 cites W1999546563 @default.
- W2787777580 cites W2000727955 @default.
- W2787777580 cites W2002382248 @default.
- W2787777580 cites W2004465286 @default.
- W2787777580 cites W2004773897 @default.
- W2787777580 cites W2005012808 @default.
- W2787777580 cites W2006444976 @default.
- W2787777580 cites W2008152503 @default.
- W2787777580 cites W2009265378 @default.
- W2787777580 cites W2009354380 @default.
- W2787777580 cites W2010333332 @default.
- W2787777580 cites W2011944576 @default.
- W2787777580 cites W2014038365 @default.
- W2787777580 cites W2015848444 @default.
- W2787777580 cites W2016213986 @default.
- W2787777580 cites W2017083690 @default.
- W2787777580 cites W2017875187 @default.
- W2787777580 cites W2018827046 @default.
- W2787777580 cites W2019479596 @default.
- W2787777580 cites W2020005420 @default.
- W2787777580 cites W2023990508 @default.
- W2787777580 cites W2026810982 @default.
- W2787777580 cites W2030132644 @default.
- W2787777580 cites W2030376476 @default.
- W2787777580 cites W2034722126 @default.
- W2787777580 cites W2036970411 @default.
- W2787777580 cites W2037466942 @default.
- W2787777580 cites W2038708057 @default.
- W2787777580 cites W2039324081 @default.
- W2787777580 cites W2039976095 @default.
- W2787777580 cites W2041176311 @default.
- W2787777580 cites W2042814879 @default.
- W2787777580 cites W2044757050 @default.
- W2787777580 cites W2050267364 @default.
- W2787777580 cites W2050774179 @default.
- W2787777580 cites W2051380380 @default.
- W2787777580 cites W2051940924 @default.
- W2787777580 cites W2053246453 @default.
- W2787777580 cites W2054680036 @default.
- W2787777580 cites W2054790877 @default.
- W2787777580 cites W2057858743 @default.
- W2787777580 cites W2062029650 @default.
- W2787777580 cites W2062267695 @default.
- W2787777580 cites W2065554630 @default.
- W2787777580 cites W2066401883 @default.
- W2787777580 cites W2068438592 @default.
- W2787777580 cites W2070270154 @default.
- W2787777580 cites W2071873707 @default.
- W2787777580 cites W2072347337 @default.
- W2787777580 cites W2072390296 @default.
- W2787777580 cites W2074851687 @default.
- W2787777580 cites W2075426423 @default.
- W2787777580 cites W2075460300 @default.
- W2787777580 cites W2075948284 @default.
- W2787777580 cites W2076361525 @default.
- W2787777580 cites W2077432635 @default.
- W2787777580 cites W2079752861 @default.