FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2787795448> ?p ?o ?g. }

• W2787795448 abstract "Estudos epidemiologicos sugerem que o desbalanco na atividade de enzimas antioxidantes, geneticamente causado, aumenta o risco de disfuncoes metabolicas e doencas cronicas nao-transmissiveis. Este e o caso do polimorfismo em que ocorre uma troca da Alanina (A) por uma Valina (V) no codon 16 do gene da enzima superoxido dismutase dependente de manganes (Ala16Val-SOD2). O alelo A possui uma eficiencia de catalise maior do que o alelo V. Entretanto, esta maior eficiencia aumenta os niveis de H2O2 levando a um consequente desbalanco oxidativo que, por sua vez, aumenta o risco de neoplasias. Por outro lado, o alelo V que apresenta uma SOD2 menos eficiente esta associado a disfuncoes endoteliais e cardiometabolicas. Portanto, este polimorfismo serve como modelo in vitro para analises de respostas diferenciais a agentes pro e antioxidantes. Sendo assim, o objetivo desse estudo foi investigar a resposta in vitro de cultura de linfocitos com diferentes genotipos (AA, VV e AV), provenientes de individuos saudaveis, expostas a radiacao ultravioleta (UV) que e um fator pro-oxidante. Antes e apos exposicao, foram analisados os efeitos citotoxicos (viabilidade celular e indice mitotico), indicadores do metabolismo oxidativo (peroxidacao lipidica, atividade enzimatica da SOD, catalase, grupos tiois, polifenois totais e de acido ascorbico) e efeitos genotoxicos (dano de DNA pelo Ensaio Cometa e instabilidade cromossomica,). Os resultados mostraram que as celulas portadoras do genotipo AA apresentaram maior viabilidade celular e indice mitotico. Entretanto, apos a exposicao UV tal viabilidade foi similar entre os genotipos. Em condicoes basais niveis elevados de SOD e polifenois totais plasmaticos foram observados no genotipo AA em relacao ao genotipo VV. Porem, linfocitos AA apresentaram maior indice de danos no DNA na presenca da radiacao UV. Estes resultados sugerem que o polimorfismo Ala16Val- SOD2 pode afetar diferencialmente a toxicidade a fatores como a radiacao UV.%%%%Epidemiological studies suggest that the imbalance in antioxidant enzymes activity genetically caused, increases the risk of metabolic disorders and chronic noncommunicable diseases. This is the case of polymorphism that occurs in an substitution of Alanine (A) by a Valine (V) at codon 16 of the gene for superoxide dismutase manganese-dependent (Ala16Val-SOD2). The A allele has a higher efficiency of catalysis than allele V. However, this efficiency increases the levels of H2O2 leading to a consequent oxidative imbalance that, in turn, increases the risk of cancer. Furthermore, the V allele that presents a smaller efficiecy SOD2 is associated with endothelial dysfunction and cardiometabolic. Therefore, Ala16VALSOD2 polymorphism serves as a model for in vitro analysis of differential responses to pro and antioxidants factors. The objective of this study was to investigate the in vitro response of lymphocytes culture with different genotypes (AA, VV and AV) from healthy subjects exposed to ultraviolet (UV) is a pro-oxidant factor. In lymphocyte not exposed and UV…" @default.
• W2787795448 created "2018-02-23" @default.
• W2787795448 creator A5087495511 @default.
• W2787795448 date "2010-03-05" @default.
• W2787795448 modified "2023-09-24" @default.
• W2787795448 title "Efeito in vitro do polimorfismo ala16val do gene da superóxido dismutase dependente de manganês no metabolismo oxidativo de linfócitos" @default.
• W2787795448 cites W1500400273 @default.
• W2787795448 cites W1531686138 @default.
• W2787795448 cites W1576198188 @default.
• W2787795448 cites W1725124326 @default.
• W2787795448 cites W1869126758 @default.
• W2787795448 cites W1891604713 @default.
• W2787795448 cites W1914622032 @default.
• W2787795448 cites W191793640 @default.
• W2787795448 cites W1940436875 @default.
• W2787795448 cites W1960899646 @default.
• W2787795448 cites W1964474617 @default.
• W2787795448 cites W1964860341 @default.
• W2787795448 cites W1969846504 @default.
• W2787795448 cites W1972060131 @default.
• W2787795448 cites W1972790402 @default.
• W2787795448 cites W1973334444 @default.
• W2787795448 cites W1973544316 @default.
• W2787795448 cites W1975328011 @default.
• W2787795448 cites W1982733091 @default.
• W2787795448 cites W1983310681 @default.
• W2787795448 cites W1992370824 @default.
• W2787795448 cites W1994534709 @default.
• W2787795448 cites W1997393792 @default.
• W2787795448 cites W2004843652 @default.
• W2787795448 cites W2007628827 @default.
• W2787795448 cites W2010094123 @default.
• W2787795448 cites W2016503982 @default.
• W2787795448 cites W2018013563 @default.
• W2787795448 cites W2024781204 @default.
• W2787795448 cites W2026296367 @default.
• W2787795448 cites W2026984649 @default.
• W2787795448 cites W2027214846 @default.
• W2787795448 cites W2029797963 @default.
• W2787795448 cites W2032901403 @default.
• W2787795448 cites W2034824188 @default.
• W2787795448 cites W2035396914 @default.
• W2787795448 cites W2041995080 @default.
• W2787795448 cites W2042770661 @default.
• W2787795448 cites W2044494908 @default.
• W2787795448 cites W2048553024 @default.
• W2787795448 cites W2050793665 @default.
• W2787795448 cites W2055860646 @default.
• W2787795448 cites W2056271246 @default.
• W2787795448 cites W2056289808 @default.
• W2787795448 cites W2057889917 @default.
• W2787795448 cites W2058496445 @default.
• W2787795448 cites W2059643569 @default.
• W2787795448 cites W2064960079 @default.
• W2787795448 cites W2067537205 @default.
• W2787795448 cites W2075214517 @default.
• W2787795448 cites W2079659331 @default.
• W2787795448 cites W2080808533 @default.
• W2787795448 cites W2084610950 @default.
• W2787795448 cites W2092629964 @default.
• W2787795448 cites W2094655287 @default.
• W2787795448 cites W2096414081 @default.
• W2787795448 cites W2097080469 @default.
• W2787795448 cites W2100281967 @default.
• W2787795448 cites W2100393265 @default.
• W2787795448 cites W2103626697 @default.
• W2787795448 cites W2104109524 @default.
• W2787795448 cites W2107409165 @default.
• W2787795448 cites W2113051236 @default.
• W2787795448 cites W2121921780 @default.
• W2787795448 cites W2126902508 @default.
• W2787795448 cites W2129258260 @default.
• W2787795448 cites W2136830554 @default.
• W2787795448 cites W2142307112 @default.
• W2787795448 cites W2143070609 @default.
• W2787795448 cites W2148641840 @default.
• W2787795448 cites W2152250291 @default.
• W2787795448 cites W2160342594 @default.
• W2787795448 cites W2161281544 @default.
• W2787795448 cites W2161327412 @default.
• W2787795448 cites W2161569099 @default.
• W2787795448 cites W2161721368 @default.
• W2787795448 cites W2163699185 @default.
• W2787795448 cites W2163910313 @default.
• W2787795448 cites W2164613158 @default.
• W2787795448 cites W2300575681 @default.
• W2787795448 cites W2408343616 @default.
• W2787795448 cites W2993542858 @default.
• W2787795448 hasPublicationYear "2010" @default.
• W2787795448 type Work @default.
• W2787795448 sameAs 2787795448 @default.
• W2787795448 citedByCount "0" @default.
• W2787795448 crossrefType "dissertation" @default.
• W2787795448 hasAuthorship W2787795448A5087495511 @default.
• W2787795448 hasConcept C153911025 @default.
• W2787795448 hasConcept C185592680 @default.
• W2787795448 hasConcept C2776151105 @default.
• W2787795448 hasConcept C2778979269 @default.
• W2787795448 hasConcept C55493867 @default.
• W2787795448 hasConcept C86803240 @default.

• next