Matches in SemOpenAlex for { <https://semopenalex.org/work/W2787817969> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2787817969 endingPage "1a" @default.
- W2787817969 startingPage "1a" @default.
- W2787817969 abstract "Inherited cardiomyopathies (diseases of the heart muscle) affect roughly one million Americans and are the leading cause of sudden death in young athletes. Identifying and treating at-risk individuals is a complex undertaking that involves many challenges. These include a large proportion of patient families that lack a recognizable genetic marker and uncertainty surrounding the mechanisms that underlie these disorders. We have developed an array of engineering-based tools to address these obstacles in the clinical management of inherited cardiomyopathies. Biophysically detailed computer models of muscle contraction are yielding insights into the relationships between gene mutations and altered heart function. Engineered heart tissue constructs, formed from patient-derived stem cells, are revealing fundamental biomechanical phenotypes that can be linked to disease expression. When combined, these in silico and in vitro methods are providing an increasingly robust path toward better risk prediction and therapy design for individual cardiomyopathy patients." @default.
- W2787817969 created "2018-02-23" @default.
- W2787817969 creator A5088951482 @default.
- W2787817969 date "2018-02-01" @default.
- W2787817969 modified "2023-09-26" @default.
- W2787817969 title "Engineering-Based Approaches to Understanding, Diagnosing, and Treating Inherited Cardiomyopathies" @default.
- W2787817969 doi "https://doi.org/10.1016/j.bpj.2017.11.030" @default.
- W2787817969 hasPublicationYear "2018" @default.
- W2787817969 type Work @default.
- W2787817969 sameAs 2787817969 @default.
- W2787817969 citedByCount "0" @default.
- W2787817969 crossrefType "journal-article" @default.
- W2787817969 hasAuthorship W2787817969A5088951482 @default.
- W2787817969 hasBestOaLocation W27878179691 @default.
- W2787817969 hasConcept C104317684 @default.
- W2787817969 hasConcept C126322002 @default.
- W2787817969 hasConcept C127716648 @default.
- W2787817969 hasConcept C164705383 @default.
- W2787817969 hasConcept C2775905019 @default.
- W2787817969 hasConcept C2778198053 @default.
- W2787817969 hasConcept C2778797674 @default.
- W2787817969 hasConcept C2779134260 @default.
- W2787817969 hasConcept C2780673598 @default.
- W2787817969 hasConcept C54355233 @default.
- W2787817969 hasConcept C60644358 @default.
- W2787817969 hasConcept C70721500 @default.
- W2787817969 hasConcept C71924100 @default.
- W2787817969 hasConcept C86803240 @default.
- W2787817969 hasConceptScore W2787817969C104317684 @default.
- W2787817969 hasConceptScore W2787817969C126322002 @default.
- W2787817969 hasConceptScore W2787817969C127716648 @default.
- W2787817969 hasConceptScore W2787817969C164705383 @default.
- W2787817969 hasConceptScore W2787817969C2775905019 @default.
- W2787817969 hasConceptScore W2787817969C2778198053 @default.
- W2787817969 hasConceptScore W2787817969C2778797674 @default.
- W2787817969 hasConceptScore W2787817969C2779134260 @default.
- W2787817969 hasConceptScore W2787817969C2780673598 @default.
- W2787817969 hasConceptScore W2787817969C54355233 @default.
- W2787817969 hasConceptScore W2787817969C60644358 @default.
- W2787817969 hasConceptScore W2787817969C70721500 @default.
- W2787817969 hasConceptScore W2787817969C71924100 @default.
- W2787817969 hasConceptScore W2787817969C86803240 @default.
- W2787817969 hasIssue "3" @default.
- W2787817969 hasLocation W27878179691 @default.
- W2787817969 hasOpenAccess W2787817969 @default.
- W2787817969 hasPrimaryLocation W27878179691 @default.
- W2787817969 hasRelatedWork W2069059418 @default.
- W2787817969 hasRelatedWork W2162016534 @default.
- W2787817969 hasRelatedWork W2492447447 @default.
- W2787817969 hasRelatedWork W2560755766 @default.
- W2787817969 hasRelatedWork W2919057908 @default.
- W2787817969 hasRelatedWork W3082576515 @default.
- W2787817969 hasRelatedWork W4224235665 @default.
- W2787817969 hasRelatedWork W4306404987 @default.
- W2787817969 hasRelatedWork W4318983165 @default.
- W2787817969 hasRelatedWork W90996600 @default.
- W2787817969 hasVolume "114" @default.
- W2787817969 isParatext "false" @default.
- W2787817969 isRetracted "false" @default.
- W2787817969 magId "2787817969" @default.
- W2787817969 workType "article" @default.