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- W2787942070 abstract "Background: Childhood obesity is one of the most serious public health challenges of the 21st century. The problem is global and the prevalencehas increased at an alarming rate. Obesity is associated with chronic inflammation and alteration in immune responses. Objective: was to investigate the effect of childhood obesity on immune cell frequency and serum leptin level in relation to insulin resistance. Method: iNKT (CD3&CD56) cells, CD4 T cells and CD56 (NK) cells were detected by flow cytometry, Leptin serum level was measured by enzyme-linked immunosorbent assay (ELISA) in 30 obese and 20 non obese children matching in age and sex. Results: invariant natural killer T cells (CD3&CD56), CD4 T cells and CD56 (NK) cells were significantly decreased in obese children compared to control group (p= 0.000). Leptin level, was significantly higher in obese children compared to control group (p=0.000). There was the significant negative correlation between (CD3&CD56), CD56 and BMI & serum Leptin levels and significant positive correlation between CD4 and BMI & serum Leptin levels. There was the significant positive correlation between serum Leptin level, BMI, LDL and homeostasis model of assessment for insulin resistance (HOMA-IR) Conclusion: childhood obesity was associated with alteration in immune cell frequency and increase serum leptin level, concomitant with increase the insulin resistance. These finding demonstrated that childhood obesitymight lead to future development of type 2 diabetes and premature cardiovascular disease in adulthood." @default.
- W2787942070 created "2018-03-06" @default.
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- W2787942070 date "2017-01-01" @default.
- W2787942070 modified "2023-09-24" @default.
- W2787942070 title "Effect of Childhood Obesity on Immune Cell Frequency and Serum Leptin Level" @default.
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