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• W2787971621 abstract "Anatomical and functional asymmetries are widespread in the animal kingdom [1Blum M. Feistel K. Thumberger T. Schweickert A. The evolution and conservation of left-right patterning mechanisms.Development. 2014; 141: 1603-1613Crossref PubMed Scopus (119) Google Scholar, 2Coutelis J.B. González-Morales N. Géminard C. Noselli S. Diversity and convergence in the mechanisms establishing L/R asymmetry in metazoa.EMBO Rep. 2014; 15: 926-937Crossref PubMed Scopus (45) Google Scholar]. In vertebrates, many visceral organs are asymmetrically placed [3Grimes D.T. Burdine R.D. Left-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis.Trends Genet. 2017; 33: 616-628Abstract Full Text Full Text PDF PubMed Scopus (72) Google Scholar]. In snails, shells and inner organs coil asymmetrically, and in Drosophila, genitalia and hindgut undergo a chiral rotation during development. The evolutionary origin of these asymmetries remains an open question [1Blum M. Feistel K. Thumberger T. Schweickert A. The evolution and conservation of left-right patterning mechanisms.Development. 2014; 141: 1603-1613Crossref PubMed Scopus (119) Google Scholar]. Nodal signaling is widely used [4Shiratori H. Hamada H. TGFβ signaling in establishing left-right asymmetry.Semin. Cell Dev. Biol. 2014; 32: 80-84Crossref PubMed Scopus (45) Google Scholar], and many, but not all, vertebrates use cilia for symmetry breaking [5Blum M. Schweickert A. Vick P. Wright C.V.E. Danilchik M.V. Symmetry breakage in the vertebrate embryo: when does it happen and how does it work?.Dev. Biol. 2014; 393: 109-123Crossref PubMed Scopus (72) Google Scholar]. In Drosophila, which lacks both cilia and Nodal, the unconventional myosin ID (myo1d) gene controls dextral rotation of chiral organs [6Hozumi S. Maeda R. Taniguchi K. Kanai M. Shirakabe S. Sasamura T. Spéder P. Noselli S. Aigaki T. Murakami R. Matsuno K. An unconventional myosin in Drosophila reverses the default handedness in visceral organs.Nature. 2006; 440: 798-802Crossref PubMed Scopus (139) Google Scholar, 7Spéder P. Adám G. Noselli S. Type ID unconventional myosin controls left-right asymmetry in Drosophila.Nature. 2006; 440: 803-807Crossref PubMed Scopus (150) Google Scholar]. Here, we studied the role of myo1d in left-right (LR) axis formation in Xenopus. Morpholino oligomer-mediated myo1d downregulation affected organ placement in >50% of morphant tadpoles. Induction of the left-asymmetric Nodal cascade was aberrant in >70% of cases. Expression of the flow-target gene dand5 was compromised, as was flow itself, due to shorter, fewer, and non-polarized cilia at the LR organizer. Additional phenotypes pinpointed Wnt/planar cell polarity signaling and suggested that myo1d, like in Drosophila [8González-Morales N. Géminard C. Lebreton G. Cerezo D. Coutelis J.-B. Noselli S. The Atypical Cadherin Dachsous Controls Left-Right Asymmetry in Drosophila.Dev. Cell. 2015; 33: 675-689Abstract Full Text Full Text PDF PubMed Scopus (41) Google Scholar], acted in the context of the planar cell polarity pathway. Indeed, convergent extension of gastrula explant cultures was inhibited in myo1d morphants, and the ATF2 reporter gene for non-canonical Wnt signaling was downregulated. Finally, genetic interference experiments demonstrated a functional interaction between the core planar cell polarity signaling gene vangl2 and myo1d in LR axis formation. Thus, our data identified myo1d as a common denominator of arthropod and chordate asymmetry, in agreement with a monophyletic origin of animal asymmetry." @default.
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• W2787971621 date "2018-03-01" @default.
• W2787971621 modified "2023-10-15" @default.
• W2787971621 title "A Conserved Role of the Unconventional Myosin 1d in Laterality Determination" @default.
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• W2787971621 doi "https://doi.org/10.1016/j.cub.2018.01.075" @default.
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