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- W2788001726 abstract "Based on the insight that only living organisms can be killed (and that killing can proceed much faster than cell-growth), we present an approach for the detection of viable microorganisms that is much faster than currently used culture-based methods. We do so by using microchannel Electrical Impedance Spectroscopy (m-EIS) for real-time detection of cell-death on exposure to a killing-agent. m-EIS relies on the fact that when living-cells with non-zero membrane potentials are exposed to high-frequency AC-field, induced-charges accumulate at the membrane-interface. Cell-death is accompanied by a loss of membrane-potential, and hence charge-storage (capacitance). A proof-of-principle for a clinical-application (detection of living mycobacteria in sputum) is demonstrated. Mycobacterium smegmatis (doubling-time ∼3 hours) and Mycobacterium bovis BCG (doubling-time ∼20 hours) in artificial-sputum are both detected in [Formula: see text]3 hours when exposed to amikacin. Times-to-detection (TTDs) are ∼12 hours and ∼84 hours (3 1/2 days), respectively for culture-based detection using current technologies (BD-MGIT-960[Formula: see text]) for samples containing similar loads of M. smegmatis and M. bovis BCG" @default.
- W2788001726 created "2018-03-06" @default.
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- W2788001726 date "2018-03-01" @default.
- W2788001726 modified "2023-09-24" @default.
- W2788001726 title "Detection by death: A rapid way to detect viable slow-growing microorganisms achieved using microchannel Electrical Impedance Spectroscopy (m-EIS)" @default.
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- W2788001726 doi "https://doi.org/10.1142/s2339547818500012" @default.
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