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• W2788045365 abstract "Abstract EDTA is widely used as an inhibitor of bacterial growth, affecting the uptake and control of metal ions by microorganisms. We describe the synthesis and characterisation of two symmetrical bis‐amide derivatives of EDTA , featuring glycyl or pyridyl substituents: AmGly 2 and AmPy 2 . Metal ion affinities (log K ) have been evaluated for a range of metals (Mg 2+ , Ca 2+ , Fe 3+ , Mn 2+ , Zn 2+ ), revealing less avid binding compared to EDTA . The solid‐state structures of AmGly 2 and of its Mg 2+ complex have been determined crystallographically. The latter shows an unusual 7‐coordinate, capped octahedral Mg 2+ centre. The antibacterial activities of the two ligands and of EDTA have been evaluated against a range of health‐relevant bacterial species, three Gram negative ( Escherichia coli , Pseudomonas aeruginosa and Klebsiella pneumoniae ) and a Gram positive ( Staphylococcus aureus ). The AmPy 2 ligand is the only one that displays a significant inhibitory effect against K. pneumoniae , but is less effective against the other organisms. AmGly 2 exhibits a more powerful inhibitory effect against E. coli at lower concentrations than EDTA (<3 m m ) or AmPy 2 , but loses its efficacy at higher concentrations. The growth inhibition of EDTA and AmGly 2 on mutant E. coli strains with defects in outer‐membrane lipopolysaccharide (LPS) structures has been assessed to provide insight into the unexpected behaviour. Taken together, the results contradict the assumption of a simple link between metal ion affinity and antimicrobial efficacy." @default.
• W2788045365 created "2018-03-06" @default.
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• W2788045365 date "2018-03-23" @default.
• W2788045365 modified "2023-10-18" @default.
• W2788045365 title "On the Antibacterial Activity of Azacarboxylate Ligands: Lowered Metal Ion Affinities for Bis-amide Derivatives of EDTA do not mean Reduced Activity" @default.
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• W2788045365 cites W1560169497 @default.
• W2788045365 cites W156939059 @default.
• W2788045365 cites W1608887834 @default.
• W2788045365 cites W1873294648 @default.
• W2788045365 cites W1895129045 @default.
• W2788045365 cites W1951178169 @default.
• W2788045365 cites W1966597734 @default.
• W2788045365 cites W1971403832 @default.
• W2788045365 cites W1971720112 @default.
• W2788045365 cites W1972185448 @default.
• W2788045365 cites W1977136736 @default.
• W2788045365 cites W1987816685 @default.
• W2788045365 cites W1991564172 @default.
• W2788045365 cites W1993954353 @default.
• W2788045365 cites W2004927612 @default.
• W2788045365 cites W2008946488 @default.
• W2788045365 cites W2009953496 @default.
• W2788045365 cites W2015905438 @default.
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• W2788045365 cites W2035610499 @default.
• W2788045365 cites W2037541009 @default.
• W2788045365 cites W2039854732 @default.
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• W2788045365 cites W2055896005 @default.
• W2788045365 cites W2060534420 @default.
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• W2788045365 cites W2069480047 @default.
• W2788045365 cites W2083560243 @default.
• W2788045365 cites W2088854169 @default.
• W2788045365 cites W2089703781 @default.
• W2788045365 cites W2092943387 @default.
• W2788045365 cites W2102528366 @default.
• W2788045365 cites W2107541106 @default.
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• W2788045365 cites W2153094536 @default.
• W2788045365 cites W2155528425 @default.
• W2788045365 cites W2160170449 @default.
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• W2788045365 doi "https://doi.org/10.1002/chem.201800026" @default.
• W2788045365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29570870" @default.
• W2788045365 hasPublicationYear "2018" @default.
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