Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788049144> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2788049144 abstract "Increasing survival from cystic fibrosis show untypical systems involvement, such as cardiocirculatory. In particular, the presence of CFTR in smooth muscle and endothelial cells, systemic inflammation and oxidative stress could explain vascular alterations in these patients. We aimed at noninvasely evaluating macro- and microvascular dysfunction in cystic fibrosis adults without cardiovascular risk factors. Twenty-twoadults affected by cystic fibrosis and 24 healthy volunteers matched for age and sex were enrolled. None had known cardiovascular risk factors. All people underwent blood pressure measurement, microvascular function assessment by EndoPAT-2000 device (calculating RH-PAT index) and macrovascular evaluation by pulse wave velocity (PWV). RH-PAT index was significantly lower in patients than in controls (1.74±0.59 vs 2.33±0.34; p<0.001). Thirteen patients of 22 had a value inferior to the threshold of 1.67 (59.1%), while no controls had (p<0.001). Carotid-femoral PWV did not differ between the two groups (5.2±1.5 m/s vs 5.4±1.1; p=0.9), while brachial-ankle one did (11.0±2.2 m/s vs 10.1±0.8 m/s; p=0.04).Adults patients affected by cystic fibrosis show peripheral endothelial dysfunction, which is the first alteration in atherosclerotic phenomenon. Moreover, arterial stiffness measured by PWV unclearly seems to differ respect of healthy people, perhaps because PWV alterations are typical of above 50 years old people. It is unclear what prognostic role of future developing of atherosclerotic disease these findings could be, but it seems evident that cystic fibrosis directly affects cardiovascular system itself." @default.
- W2788049144 created "2018-03-06" @default.
- W2788049144 creator A5004576996 @default.
- W2788049144 creator A5005971804 @default.
- W2788049144 creator A5020219999 @default.
- W2788049144 creator A5021732191 @default.
- W2788049144 creator A5033351714 @default.
- W2788049144 creator A5053760015 @default.
- W2788049144 creator A5058642066 @default.
- W2788049144 creator A5059998490 @default.
- W2788049144 creator A5061512474 @default.
- W2788049144 creator A5077709879 @default.
- W2788049144 creator A5078153664 @default.
- W2788049144 date "2019-05-20" @default.
- W2788049144 modified "2023-10-01" @default.
- W2788049144 title "Macro- and microvascular functions in cystic fibrosis adults without cardiovascular risk factors: A case-control study" @default.
- W2788049144 doi "https://doi.org/10.4081/monaldi.2019.1035" @default.
- W2788049144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31107040" @default.
- W2788049144 hasPublicationYear "2019" @default.
- W2788049144 type Work @default.
- W2788049144 sameAs 2788049144 @default.
- W2788049144 citedByCount "6" @default.
- W2788049144 countsByYear W27880491442020 @default.
- W2788049144 countsByYear W27880491442021 @default.
- W2788049144 countsByYear W27880491442022 @default.
- W2788049144 crossrefType "journal-article" @default.
- W2788049144 hasAuthorship W2788049144A5004576996 @default.
- W2788049144 hasAuthorship W2788049144A5005971804 @default.
- W2788049144 hasAuthorship W2788049144A5020219999 @default.
- W2788049144 hasAuthorship W2788049144A5021732191 @default.
- W2788049144 hasAuthorship W2788049144A5033351714 @default.
- W2788049144 hasAuthorship W2788049144A5053760015 @default.
- W2788049144 hasAuthorship W2788049144A5058642066 @default.
- W2788049144 hasAuthorship W2788049144A5059998490 @default.
- W2788049144 hasAuthorship W2788049144A5061512474 @default.
- W2788049144 hasAuthorship W2788049144A5077709879 @default.
- W2788049144 hasAuthorship W2788049144A5078153664 @default.
- W2788049144 hasBestOaLocation W27880491441 @default.
- W2788049144 hasConcept C120770815 @default.
- W2788049144 hasConcept C126322002 @default.
- W2788049144 hasConcept C164705383 @default.
- W2788049144 hasConcept C2775850156 @default.
- W2788049144 hasConcept C2776938444 @default.
- W2788049144 hasConcept C2778319312 @default.
- W2788049144 hasConcept C2780559512 @default.
- W2788049144 hasConcept C2780972559 @default.
- W2788049144 hasConcept C3019128504 @default.
- W2788049144 hasConcept C71924100 @default.
- W2788049144 hasConcept C84393581 @default.
- W2788049144 hasConcept C90924648 @default.
- W2788049144 hasConceptScore W2788049144C120770815 @default.
- W2788049144 hasConceptScore W2788049144C126322002 @default.
- W2788049144 hasConceptScore W2788049144C164705383 @default.
- W2788049144 hasConceptScore W2788049144C2775850156 @default.
- W2788049144 hasConceptScore W2788049144C2776938444 @default.
- W2788049144 hasConceptScore W2788049144C2778319312 @default.
- W2788049144 hasConceptScore W2788049144C2780559512 @default.
- W2788049144 hasConceptScore W2788049144C2780972559 @default.
- W2788049144 hasConceptScore W2788049144C3019128504 @default.
- W2788049144 hasConceptScore W2788049144C71924100 @default.
- W2788049144 hasConceptScore W2788049144C84393581 @default.
- W2788049144 hasConceptScore W2788049144C90924648 @default.
- W2788049144 hasIssue "2" @default.
- W2788049144 hasLocation W27880491441 @default.
- W2788049144 hasLocation W27880491442 @default.
- W2788049144 hasLocation W27880491443 @default.
- W2788049144 hasOpenAccess W2788049144 @default.
- W2788049144 hasPrimaryLocation W27880491441 @default.
- W2788049144 hasRelatedWork W2119148367 @default.
- W2788049144 hasRelatedWork W2625299409 @default.
- W2788049144 hasRelatedWork W2743643118 @default.
- W2788049144 hasRelatedWork W2793577865 @default.
- W2788049144 hasRelatedWork W2977456203 @default.
- W2788049144 hasRelatedWork W3024619661 @default.
- W2788049144 hasRelatedWork W3031966556 @default.
- W2788049144 hasRelatedWork W3042096560 @default.
- W2788049144 hasRelatedWork W3148846798 @default.
- W2788049144 hasRelatedWork W4322616795 @default.
- W2788049144 hasVolume "89" @default.
- W2788049144 isParatext "false" @default.
- W2788049144 isRetracted "false" @default.
- W2788049144 magId "2788049144" @default.
- W2788049144 workType "article" @default.