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• W2788051985 abstract "No AccessJournal of UrologyReview Article1 Jul 2018Gender Specific Differences in Disease-Free, Cancer Specific and Overall Survival after Radical Cystectomy for Bladder Cancer: A Systematic Review and Meta-Analysis Annemarie Uhlig, Ali Seif Amir Hosseini, Jörg Simon, Joachim Lotz, Lutz Trojan, Marianne Schmid, and Johannes Uhlig Annemarie UhligAnnemarie Uhlig Department of Urology, University Medical Center Goettingen, Goettingen, Germany More articles by this author , Ali Seif Amir HosseiniAli Seif Amir Hosseini Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Goettingen, Germany More articles by this author , Jörg SimonJörg Simon Department of Urology and Pediatric Urology, Ortenau Hospital, Offenburg, Germany More articles by this author , Joachim LotzJoachim Lotz Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Goettingen, Germany More articles by this author , Lutz TrojanLutz Trojan Department of Urology, University Medical Center Goettingen, Goettingen, Germany More articles by this author , Marianne SchmidMarianne Schmid Department of Urology, University Medical Center Goettingen, Goettingen, Germany Equal study contribution. More articles by this author , and Johannes UhligJohannes Uhlig Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Goettingen, Germany Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut Equal study contribution. More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.11.150AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We summarize the evidence on gender specific differences in disease-free, cancer specific and overall survival after radical cystectomy for bladder cancer. Materials and Methods: We performed a systematic literature search of MEDLINE®, Embase® and the Cochrane Library in July 2017. Studies evaluating gender specific differences in disease-free, cancer specific or overall survival after radical cystectomy for bladder cancer were included in study. Analyses included random effect meta-analysis, subgroup analyses, meta-influence and cumulative meta-analyses. Funnel plots and the Egger test were used to assess publication bias. Results: Of the 3,868 studies identified during the literature search 59 published between 1998 and 2017 were included in analysis. Of the studies 30 in a total of 38,321 patients evaluated disease-free survival, 44 in a total of 69,666 evaluated cancer specific survival and 26 in a total of 30,039 evaluated overall survival. Random effect meta-analyses revealed decreased disease-free, cancer specific survival and overall survival in female patients than in their male counterparts. Pooled estimates showed a HR of 1.16 (95% CI 1.06–1.27, p = 0.0018) for disease-free survival, 1.23 (95% CI 1.15–1.31, p <0.001) for cancer specific survival and 1.08 (95% CI 1.03–1.12, p = 0.0004) for overall survival. Subgroup analyses confirmed impaired disease-free, cancer specific and overall survival in female patients in all strata. Publication bias was evident only for studies of cancer specific survival (Egger test p = 0.0029). After adjusting for publication bias by the trim and fill method the corrected pooled estimated HR of cancer specific survival was 1.13 (95% CI 1.05–1.21, p = 0.0012). Conclusions: Female patients who underwent radical cystectomy for bladder cancer demonstrated worse disease-free, cancer specific and overall survival than their male counterparts. The multifactorial etiology might include epidemiological differences, gender specific health care discrepancies and hormonal influences. References 1 Howlader N, Noone A, Krapcho M et al: SEER Cancer Statistics Review, 1975-2014. Bethesda, Maryland: National Cancer Institute 2017. Available at https://seer.cancer.gov/csr/1975_2014/. Accessed November 5, 2017. 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Google Scholar © 2018 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 200Issue 1July 2018Page: 48-60Supplementary Materials Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.Keywordsurinary bladder neoplasmsfemalecystectomymalemortalityMetricsAuthor Information Annemarie Uhlig Department of Urology, University Medical Center Goettingen, Goettingen, Germany More articles by this author Ali Seif Amir Hosseini Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Goettingen, Germany More articles by this author Jörg Simon Department of Urology and Pediatric Urology, Ortenau Hospital, Offenburg, Germany More articles by this author Joachim Lotz Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Goettingen, Germany More articles by this author Lutz Trojan Department of Urology, University Medical Center Goettingen, Goettingen, Germany More articles by this author Marianne Schmid Department of Urology, University Medical Center Goettingen, Goettingen, Germany Equal study contribution. More articles by this author Johannes Uhlig Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Goettingen, Germany Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut Equal study contribution. More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2788051985 title "Gender Specific Differences in Disease-Free, Cancer Specific and Overall Survival after Radical Cystectomy for Bladder Cancer: A Systematic Review and Meta-Analysis" @default.
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