Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788084906> ?p ?o ?g. }
- W2788084906 endingPage "116" @default.
- W2788084906 startingPage "112" @default.
- W2788084906 abstract "Oncogene-induced DNA replication stress contributes critically to the genomic instability that is present in cancer. However, elucidating how oncogenes deregulate DNA replication has been impeded by difficulty in mapping replication initiation sites on the human genome. Here, using a sensitive assay to monitor nascent DNA synthesis in early S phase, we identified thousands of replication initiation sites in cells before and after induction of the oncogenes CCNE1 and MYC. Remarkably, both oncogenes induced firing of a novel set of DNA replication origins that mapped within highly transcribed genes. These ectopic origins were normally suppressed by transcription during G1, but precocious entry into S phase, before all genic regions had been transcribed, allowed firing of origins within genes in cells with activated oncogenes. Forks from oncogene-induced origins were prone to collapse, as a result of conflicts between replication and transcription, and were associated with DNA double-stranded break formation and chromosomal rearrangement breakpoints both in our experimental system and in a large cohort of human cancers. Thus, firing of intragenic origins caused by premature S phase entry represents a mechanism of oncogene-induced DNA replication stress that is relevant for genomic instability in human cancer." @default.
- W2788084906 created "2018-03-06" @default.
- W2788084906 creator A5014991432 @default.
- W2788084906 creator A5019478811 @default.
- W2788084906 date "2018-02-21" @default.
- W2788084906 modified "2023-10-01" @default.
- W2788084906 title "Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress" @default.
- W2788084906 cites W1964640891 @default.
- W2788084906 cites W1976853883 @default.
- W2788084906 cites W1984373702 @default.
- W2788084906 cites W1994183178 @default.
- W2788084906 cites W2016661249 @default.
- W2788084906 cites W2033221504 @default.
- W2788084906 cites W2041156660 @default.
- W2788084906 cites W2043745733 @default.
- W2788084906 cites W2065779053 @default.
- W2788084906 cites W2067573570 @default.
- W2788084906 cites W2071734901 @default.
- W2788084906 cites W2072659475 @default.
- W2788084906 cites W2086333179 @default.
- W2788084906 cites W2094569502 @default.
- W2788084906 cites W2099929096 @default.
- W2788084906 cites W2103441770 @default.
- W2788084906 cites W2105590267 @default.
- W2788084906 cites W2113896971 @default.
- W2788084906 cites W2121371748 @default.
- W2788084906 cites W2141689006 @default.
- W2788084906 cites W2142796669 @default.
- W2788084906 cites W2149326681 @default.
- W2788084906 cites W2153056550 @default.
- W2788084906 cites W2153087859 @default.
- W2788084906 cites W2157443952 @default.
- W2788084906 cites W2159342107 @default.
- W2788084906 cites W2165860917 @default.
- W2788084906 cites W2234143669 @default.
- W2788084906 cites W2335547104 @default.
- W2788084906 cites W2531499154 @default.
- W2788084906 cites W4231271646 @default.
- W2788084906 doi "https://doi.org/10.1038/nature25507" @default.
- W2788084906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5837010" @default.
- W2788084906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29466339" @default.
- W2788084906 hasPublicationYear "2018" @default.
- W2788084906 type Work @default.
- W2788084906 sameAs 2788084906 @default.
- W2788084906 citedByCount "276" @default.
- W2788084906 countsByYear W27880849062018 @default.
- W2788084906 countsByYear W27880849062019 @default.
- W2788084906 countsByYear W27880849062020 @default.
- W2788084906 countsByYear W27880849062021 @default.
- W2788084906 countsByYear W27880849062022 @default.
- W2788084906 countsByYear W27880849062023 @default.
- W2788084906 crossrefType "journal-article" @default.
- W2788084906 hasAuthorship W2788084906A5014991432 @default.
- W2788084906 hasAuthorship W2788084906A5019478811 @default.
- W2788084906 hasBestOaLocation W27880849062 @default.
- W2788084906 hasConcept C104317684 @default.
- W2788084906 hasConcept C104690221 @default.
- W2788084906 hasConcept C138885662 @default.
- W2788084906 hasConcept C143425029 @default.
- W2788084906 hasConcept C151158763 @default.
- W2788084906 hasConcept C175193931 @default.
- W2788084906 hasConcept C178169997 @default.
- W2788084906 hasConcept C179926584 @default.
- W2788084906 hasConcept C2778512757 @default.
- W2788084906 hasConcept C2781018059 @default.
- W2788084906 hasConcept C29537977 @default.
- W2788084906 hasConcept C41141232 @default.
- W2788084906 hasConcept C41895202 @default.
- W2788084906 hasConcept C54266558 @default.
- W2788084906 hasConcept C54355233 @default.
- W2788084906 hasConcept C552990157 @default.
- W2788084906 hasConcept C67419583 @default.
- W2788084906 hasConcept C73573662 @default.
- W2788084906 hasConcept C86803240 @default.
- W2788084906 hasConcept C98086919 @default.
- W2788084906 hasConceptScore W2788084906C104317684 @default.
- W2788084906 hasConceptScore W2788084906C104690221 @default.
- W2788084906 hasConceptScore W2788084906C138885662 @default.
- W2788084906 hasConceptScore W2788084906C143425029 @default.
- W2788084906 hasConceptScore W2788084906C151158763 @default.
- W2788084906 hasConceptScore W2788084906C175193931 @default.
- W2788084906 hasConceptScore W2788084906C178169997 @default.
- W2788084906 hasConceptScore W2788084906C179926584 @default.
- W2788084906 hasConceptScore W2788084906C2778512757 @default.
- W2788084906 hasConceptScore W2788084906C2781018059 @default.
- W2788084906 hasConceptScore W2788084906C29537977 @default.
- W2788084906 hasConceptScore W2788084906C41141232 @default.
- W2788084906 hasConceptScore W2788084906C41895202 @default.
- W2788084906 hasConceptScore W2788084906C54266558 @default.
- W2788084906 hasConceptScore W2788084906C54355233 @default.
- W2788084906 hasConceptScore W2788084906C552990157 @default.
- W2788084906 hasConceptScore W2788084906C67419583 @default.
- W2788084906 hasConceptScore W2788084906C73573662 @default.
- W2788084906 hasConceptScore W2788084906C86803240 @default.
- W2788084906 hasConceptScore W2788084906C98086919 @default.
- W2788084906 hasIssue "7694" @default.
- W2788084906 hasLocation W27880849061 @default.
- W2788084906 hasLocation W27880849062 @default.