Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788143811> ?p ?o ?g. }
- W2788143811 endingPage "48" @default.
- W2788143811 startingPage "48" @default.
- W2788143811 abstract "Two primary causes of respiratory tract infections are respiratory syncytial virus (RSV) and influenza viruses, both of which remain major public health concerns. There are a limited number of antiviral drugs available for the treatment of RSV and influenza, each having limited effectiveness and each driving selective pressure for the emergence of drug-resistant viruses. Novel broad-spectrum antivirals are needed to circumvent problems with current disease intervention strategies, while improving the cytokine-induced immunopathology associated with RSV and influenza infections. In this review, we examine the use of Verdinexor (KPT-335, a novel orally bioavailable drug that functions as a selective inhibitor of nuclear export, SINE), as an antiviral with multifaceted therapeutic potential. KPT-335 works to (1) block CRM1 (i.e., Chromosome Region Maintenance 1; exportin 1 or XPO1) mediated export of viral proteins critical for RSV and influenza pathogenesis; and (2) repress nuclear factor κB (NF-κB) activation, thus reducing cytokine production and eliminating virus-associated immunopathology. The repurposing of SINE compounds as antivirals shows promise not only against RSV and influenza virus but also against other viruses that exploit the nucleus as part of their viral life cycle." @default.
- W2788143811 created "2018-03-06" @default.
- W2788143811 creator A5053051899 @default.
- W2788143811 creator A5071591946 @default.
- W2788143811 date "2018-01-21" @default.
- W2788143811 modified "2023-09-25" @default.
- W2788143811 title "Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses" @default.
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