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- W2788168718 abstract "Treatment of inflammatory disorders relies on the intervention in immune responses thereby restoring homeostasis. IL-10 is a cytokine with therapeutic potential, but until now has not been as successful as previously anticipated. A reason for this may be that IL-10 responsiveness depends on the environment of the inflamed tissue. In this study we investigated whether GM-CSF is able to influence IL-10-mediated responses.Dendritic cells and macrophages were differentiated from mouse bone marrow and treated or depleted from GM-CSF prior to analyze their response to IL-10. Activity was assessed by measuring cytokine expression upon lipopolysaccharide stimulation, IL-10-induced signaling and down-stream gene expression.This study describes that GM-CSF negatively regulates IL-10-mediated responses." @default.
- W2788168718 created "2018-03-06" @default.
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- W2788168718 date "2018-04-01" @default.
- W2788168718 modified "2023-09-27" @default.
- W2788168718 title "Granulocyte-macrophage colony-stimulating factor negatively regulates early IL-10-mediated responses" @default.
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- W2788168718 doi "https://doi.org/10.4155/fsoa-2017-0133" @default.
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- W2788168718 hasPublicationYear "2018" @default.
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