FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788200071> ?p ?o ?g. }

• W2788200071 endingPage "3080" @default.
• W2788200071 startingPage "3060" @default.
• W2788200071 abstract "Acute influenza infection has been reported to be associated with neurological symptoms. However, the long-term consequences of an infection with neurotropic and non-neurotropic influenza A virus (IAV) variants for the CNS remain elusive. We can show that spine loss in the hippocampus after infection with neurotropic H7N7 (rSC35M) and non-neurotropic H3N2 (maHK68) in female C57BL/6 mice persists well beyond the acute phase of the disease. Although spine number was significantly reduced at 30 d postinfection (dpi) with H7N7 or H3N2, full recovery could only be observed much later at 120 dpi. Infection with H1N1 virus, which was shown previously to affect spine number and hippocampus-dependent learning acutely, had no significant long-term effects. Spine loss was associated with an increase in the number of activated microglia, reduced long-term potentiation in the hippocampus, and impairment in spatial memory formation, indicating that IAV-associated inflammation induced functional and structural alterations in hippocampal networks. Transcriptome analyses revealed regulation of many inflammatory and neuron- and glia-specific genes in H3N2- and H7N7-infected mice at day 18 and in H7N7-infected mice at day 30 pi that related to the structural and functional alterations. Our data provide evidence that neuroinflammation induced by neurotropic H7N7 and infection of the lung with a non-neurotropic H3N2 IAV result in long-term impairments in the CNS. IAV infection in humans may therefore not only lead to short-term responses in infected organs, but may also trigger neuroinflammation and associated chronic alterations in the CNS. SIGNIFICANCE STATEMENT In the acute phase of influenza infection, neuroinflammation can lead to alterations in hippocampal neuronal morphology and cognitive deficits. The results of this study now also provide evidence that neuroinflammation induced by influenza A virus (IAV) infection can induce longer-lasting, virus-specific alterations in neuronal connectivity that are still detectable 1 month after infection and are associated with impairments in spatial memory formation. IAV infection in humans may therefore not only lead to short-term responses in infected organs, but may also trigger neuroinflammation and associated chronic alterations in the CNS." @default.
• W2788200071 created "2018-03-06" @default.
• W2788200071 creator A5018606858 @default.
• W2788200071 creator A5020416104 @default.
• W2788200071 creator A5031612388 @default.
• W2788200071 creator A5038499176 @default.
• W2788200071 creator A5039349322 @default.
• W2788200071 creator A5057086681 @default.
• W2788200071 creator A5068954911 @default.
• W2788200071 creator A5080547447 @default.
• W2788200071 date "2018-02-27" @default.
• W2788200071 modified "2023-10-12" @default.
• W2788200071 title "Long-Term Neuroinflammation Induced by Influenza A Virus Infection and the Impact on Hippocampal Neuron Morphology and Function" @default.
• W2788200071 cites W1498791230 @default.
• W2788200071 cites W1547086125 @default.
• W2788200071 cites W1553210510 @default.
• W2788200071 cites W1585088309 @default.
• W2788200071 cites W1827177868 @default.
• W2788200071 cites W1966829335 @default.
• W2788200071 cites W1967061503 @default.
• W2788200071 cites W1971525867 @default.
• W2788200071 cites W1980234595 @default.
• W2788200071 cites W1980829155 @default.
• W2788200071 cites W1984397554 @default.
• W2788200071 cites W1986611577 @default.
• W2788200071 cites W1989369404 @default.
• W2788200071 cites W1991423390 @default.
• W2788200071 cites W1994580609 @default.
• W2788200071 cites W1994707167 @default.
• W2788200071 cites W1996024251 @default.
• W2788200071 cites W1998055329 @default.
• W2788200071 cites W2001682194 @default.
• W2788200071 cites W2004349171 @default.
• W2788200071 cites W2004854973 @default.
• W2788200071 cites W2007989000 @default.
• W2788200071 cites W2008121982 @default.
• W2788200071 cites W2010000553 @default.
• W2788200071 cites W2010274822 @default.
• W2788200071 cites W2011829284 @default.
• W2788200071 cites W2012182735 @default.
• W2788200071 cites W2014396748 @default.
• W2788200071 cites W2015663762 @default.
• W2788200071 cites W2015851283 @default.
• W2788200071 cites W2016575029 @default.
• W2788200071 cites W2020182778 @default.
• W2788200071 cites W2022753212 @default.
• W2788200071 cites W2023474435 @default.
• W2788200071 cites W2026917639 @default.
• W2788200071 cites W2027440189 @default.
• W2788200071 cites W2033628698 @default.
• W2788200071 cites W2034724560 @default.
• W2788200071 cites W2035618305 @default.
• W2788200071 cites W2037476083 @default.
• W2788200071 cites W2039047987 @default.
• W2788200071 cites W2047579925 @default.
• W2788200071 cites W2050593289 @default.
• W2788200071 cites W2052783666 @default.
• W2788200071 cites W2052831884 @default.
• W2788200071 cites W2054594878 @default.
• W2788200071 cites W2069358581 @default.
• W2788200071 cites W2069465895 @default.
• W2788200071 cites W2071195063 @default.
• W2788200071 cites W2079714688 @default.
• W2788200071 cites W2081098333 @default.
• W2788200071 cites W2083048709 @default.
• W2788200071 cites W2084091436 @default.
• W2788200071 cites W2084839197 @default.
• W2788200071 cites W2087816970 @default.
• W2788200071 cites W2090804892 @default.
• W2788200071 cites W2091006895 @default.
• W2788200071 cites W2091405647 @default.
• W2788200071 cites W2094660330 @default.
• W2788200071 cites W2095241201 @default.
• W2788200071 cites W2096500024 @default.
• W2788200071 cites W2096517282 @default.
• W2788200071 cites W2097740790 @default.
• W2788200071 cites W2103734768 @default.
• W2788200071 cites W2111323042 @default.
• W2788200071 cites W2116787729 @default.
• W2788200071 cites W2119353857 @default.
• W2788200071 cites W2119614109 @default.
• W2788200071 cites W2127936752 @default.
• W2788200071 cites W2130074917 @default.
• W2788200071 cites W2130775735 @default.
• W2788200071 cites W2133519060 @default.
• W2788200071 cites W2136210766 @default.
• W2788200071 cites W2137956145 @default.
• W2788200071 cites W2138475095 @default.
• W2788200071 cites W2139565721 @default.
• W2788200071 cites W2140019947 @default.
• W2788200071 cites W2143079975 @default.
• W2788200071 cites W2152448916 @default.
• W2788200071 cites W2153308987 @default.
• W2788200071 cites W2160697532 @default.
• W2788200071 cites W2164718528 @default.
• W2788200071 cites W2169473035 @default.
• W2788200071 cites W2203645773 @default.
• W2788200071 cites W2277726453 @default.

• next