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- W2788264925 abstract "INTRODUCTION :Coronary artery disease (CAD) is one of the leading cause ofmorbidity and mortality in the world and has nearing its epidemicproportions. Coronary artery disease causes 9.4 percent of total deaths (25lakhs) in under developed countries and 16.3 percent (13 lakhs) of alldeaths in developed countries1. The world health organisation (WHO) hascalculated the year of 2002 alone, 12.6 percent of deaths in the world werebecause of CAD2. The proportion of CAD is expected to increase as it isdisease of aging and the world population getting older.The India has similar scenario, Indian studies has revealedthat cardiovascular diseases (CVD) cause about 40% of deaths in the urbanareas and 30% of deaths in rural areas in india3. Prevalence of cardiovascular disease in the adult population has multiplied in urban areas fromaround 2% in early 1960’s to 6.5% in late 1970’s, 7% during the year1980, to close 10 % in 1990 and to a critical 10.5% in the year 2000, thesame time in rural areas, it is increased to a smaller extent from about 2%during 1970, to 2.5% in late 1980’s , and to calculated 4% in the 1990, atlast the prevalence has reached 4.5% in 2000.Diastolic stress test mainly used to diagnose elevated fillingpressure in patients with exertional dyspnoea associated with normal fillingpressure at rest. The elevated filling pressure during exercise reflectscardiac cause of dyspnoea, this can be measured by early mitral velocity(E) and early mitral tissue velocity (E’). This idea extrapolated in patientswith chest pain with normal LV function to identify myocardial ischemiawhich increases LV filling pressure.Based on the concept diastolic abnormalities occur earlier thansymptoms, electrocardiographic changes and systolic dysfunction duringmyocardial ischemia. Diastolic stress test should identify ischemia earlierthan other type of stress test methods4. My study is looking into thesequestions and answers.AIM OF STUDY :1. To calculate tissue Doppler velocity parameter in normal andcoronary artery disease patients2. To measure changes in TDI parameters immediately after stress3. To identify changes in E/E’ during normal and after stress4. Changes in E/E’ can detect coronary artery disease and its severityCONCLUSION :1. The systolic velocity S’ is reduced in patients with obstructive CAD2. The average E/E’ ratio in Indian population during rest without CADis 8.37 but slightly increased in CAD patients ( 9.37 )3. There is significant reduction of all diastolic parameters E’, A’ withstress test noted in patients with CAD4. A significant increase in E/E’ ratio (3.15 + 1.92) from baselineirrespective of baseline value during stress test highly correlated withpresence of obstructive CAD.5. The baseline and stress E/E’ ratio incrementally increased as severityof CAD increases.6. Post treadmill exercise echocardiography using TDI to measure E/E’ratio increases sensitivity of CAD detection form 56% to 71% in ourstudy." @default.
- W2788264925 created "2018-03-06" @default.
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- W2788264925 date "2014-08-01" @default.
- W2788264925 modified "2023-09-27" @default.
- W2788264925 title "Diastolic stress test-novel marker to detect Coronary Artery Disease - A Tissue Doppler Echocardiographic study." @default.
- W2788264925 hasPublicationYear "2014" @default.
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