Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788287081> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2788287081 endingPage "1267" @default.
- W2788287081 startingPage "1259" @default.
- W2788287081 abstract "Background: Due to the increase of multidrug-resistant microorganisms, the search for biologically active molecules does not stop. In the present study, we developed the effective QSAR model which allows a quick search of new potential Staphylococcus aureus inhibitors in the series of quaternary phosphonium salts. A number of the most promising 1,3-oxazol-4-yltriphenylphosphonium derivatives with predicted activities were synthesized and examined to confirm their antibacterial properties and the accuracy of the forecast. Furthermore, the toxicity of the investigated compounds was evaluated. Methods: The predictive QSAR model was developed using Artificial Neural Network approach. Antibacterial properties of the investigated compounds were performed using standard disk diffusion method. The toxicity of the compounds was determined in vivo using zebrafish (Danio rerio) and in vitro on acetylcholinesterase (AChE) enzyme as the test models. Results: The predictive ability of the regression model was tested by cross-validation, giving the cross-validated coefficient q2=0.82. Derivatives of 1,3-oxazol-4-yltriphenylphosphonium salts predicted as active were synthesized and screened for their antibacterial activities. All compounds demonstrated antibacterial activity according to the prediction. The toxicity tests indicated that all investigated samples were less toxic than well-known cationic surfactants. Conclusion: The most promising compound 2b exhibited strong antibacterial activity together with low toxicity and can be considered as a new efficient biocidal agent for future investigation. In addition, the proposed QSAR model can be used for predicting and designing novel potential S. aureus inhibitors among ionic liquids/salts." @default.
- W2788287081 created "2018-03-06" @default.
- W2788287081 creator A5009744325 @default.
- W2788287081 creator A5014769949 @default.
- W2788287081 creator A5017651727 @default.
- W2788287081 creator A5037386566 @default.
- W2788287081 creator A5038778165 @default.
- W2788287081 creator A5039471726 @default.
- W2788287081 creator A5061754702 @default.
- W2788287081 creator A5067746744 @default.
- W2788287081 creator A5083073317 @default.
- W2788287081 date "2018-12-01" @default.
- W2788287081 modified "2023-09-26" @default.
- W2788287081 title "New 1,3-oxazolylphosphonium Salts as Potential Biocides: QSAR Study, Synthesis, Antibacterial Activity and Toxicity Evaluation" @default.
- W2788287081 doi "https://doi.org/10.2174/1570180815666180219164334" @default.
- W2788287081 hasPublicationYear "2018" @default.
- W2788287081 type Work @default.
- W2788287081 sameAs 2788287081 @default.
- W2788287081 citedByCount "10" @default.
- W2788287081 countsByYear W27882870812019 @default.
- W2788287081 countsByYear W27882870812020 @default.
- W2788287081 countsByYear W27882870812021 @default.
- W2788287081 countsByYear W27882870812022 @default.
- W2788287081 crossrefType "journal-article" @default.
- W2788287081 hasAuthorship W2788287081A5009744325 @default.
- W2788287081 hasAuthorship W2788287081A5014769949 @default.
- W2788287081 hasAuthorship W2788287081A5017651727 @default.
- W2788287081 hasAuthorship W2788287081A5037386566 @default.
- W2788287081 hasAuthorship W2788287081A5038778165 @default.
- W2788287081 hasAuthorship W2788287081A5039471726 @default.
- W2788287081 hasAuthorship W2788287081A5061754702 @default.
- W2788287081 hasAuthorship W2788287081A5067746744 @default.
- W2788287081 hasAuthorship W2788287081A5083073317 @default.
- W2788287081 hasConcept C164126121 @default.
- W2788287081 hasConcept C178790620 @default.
- W2788287081 hasConcept C183882617 @default.
- W2788287081 hasConcept C185592680 @default.
- W2788287081 hasConcept C21951064 @default.
- W2788287081 hasConcept C2780104969 @default.
- W2788287081 hasConcept C2780707935 @default.
- W2788287081 hasConcept C29730261 @default.
- W2788287081 hasConcept C523546767 @default.
- W2788287081 hasConcept C54355233 @default.
- W2788287081 hasConcept C71240020 @default.
- W2788287081 hasConcept C86803240 @default.
- W2788287081 hasConceptScore W2788287081C164126121 @default.
- W2788287081 hasConceptScore W2788287081C178790620 @default.
- W2788287081 hasConceptScore W2788287081C183882617 @default.
- W2788287081 hasConceptScore W2788287081C185592680 @default.
- W2788287081 hasConceptScore W2788287081C21951064 @default.
- W2788287081 hasConceptScore W2788287081C2780104969 @default.
- W2788287081 hasConceptScore W2788287081C2780707935 @default.
- W2788287081 hasConceptScore W2788287081C29730261 @default.
- W2788287081 hasConceptScore W2788287081C523546767 @default.
- W2788287081 hasConceptScore W2788287081C54355233 @default.
- W2788287081 hasConceptScore W2788287081C71240020 @default.
- W2788287081 hasConceptScore W2788287081C86803240 @default.
- W2788287081 hasIssue "12" @default.
- W2788287081 hasLocation W27882870811 @default.
- W2788287081 hasOpenAccess W2788287081 @default.
- W2788287081 hasPrimaryLocation W27882870811 @default.
- W2788287081 hasRelatedWork W2030362629 @default.
- W2788287081 hasRelatedWork W2065081838 @default.
- W2788287081 hasRelatedWork W2079665383 @default.
- W2788287081 hasRelatedWork W2084972314 @default.
- W2788287081 hasRelatedWork W2415468500 @default.
- W2788287081 hasRelatedWork W2766534390 @default.
- W2788287081 hasRelatedWork W2788287081 @default.
- W2788287081 hasRelatedWork W2949827842 @default.
- W2788287081 hasRelatedWork W2951490882 @default.
- W2788287081 hasRelatedWork W2952365740 @default.
- W2788287081 hasVolume "15" @default.
- W2788287081 isParatext "false" @default.
- W2788287081 isRetracted "false" @default.
- W2788287081 magId "2788287081" @default.
- W2788287081 workType "article" @default.