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• W2788297319 startingPage "890" @default.
• W2788297319 abstract "The existence of bipotential precursors for both mesenchymal and endothelial stem/progenitor cells in human postnatal life is debated. Here, we hypothesized that such progenitors are present within the human term placenta. From a heterogeneous placental single-cell suspension, a directly flow-sorted CD45−CD34+CD144+CD31Lo population uniquely differentiated into both endothelial and mesenchymal colonies in limiting dilution culture assays. Of interest, these bipotent cells were in vessel walls but not in contact with the circulation. RNA sequencing and functional analysis demonstrated that Notch signaling was a key driver for endothelial and bipotential progenitor function. In contrast, the formation of mesenchymal cells from the bipotential population was not affected by TGFβ receptor inhibition, a classical pathway for endothelial-mesenchymal transition. This study reveals a bipotent progenitor phenotype in the human placenta at the cellular and molecular levels, giving rise to endothelial and mesenchymal cells ex vivo." @default.
• W2788297319 created "2018-03-06" @default.
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• W2788297319 date "2018-03-01" @default.
• W2788297319 modified "2023-10-12" @default.
• W2788297319 title "Meso-Endothelial Bipotent Progenitors from Human Placenta Display Distinct Molecular and Cellular Identity" @default.
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• W2788297319 doi "https://doi.org/10.1016/j.stemcr.2018.01.011" @default.
• W2788297319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5918195" @default.
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