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• W2788314063 abstract "Whole-body systemic gene therapy is likely the most effective way to reduce greatly the disease burden of Duchenne muscular dystrophy (DMD), an X-linked inherited muscle disease that leads to premature death in early adulthood. Genetically, DMD is due to null mutation of the dystrophin gene, one of the largest genes in the genome. Recent studies have shown highly promising improvements in animal models with intravascular delivery of the engineered micro-dystrophin gene by adeno-associated virus (AAV). Several human trials are now started to advance AAV micro-dystrophin therapy to DMD patients. This is a historical moment for the entire field. Results from these trials will shape the future of neuromuscular disease gene therapy." @default.
• W2788314063 created "2018-03-06" @default.
• W2788314063 creator A5071836454 @default.
• W2788314063 date "2018-07-01" @default.
• W2788314063 modified "2023-10-08" @default.
• W2788314063 title "Micro-Dystrophin Gene Therapy Goes Systemic in Duchenne Muscular Dystrophy Patients" @default.
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• W2788314063 doi "https://doi.org/10.1089/hum.2018.012" @default.
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