Matches in SemOpenAlex for { <https://semopenalex.org/work/W278833301> ?p ?o ?g. }
- W278833301 endingPage "40" @default.
- W278833301 startingPage "40" @default.
- W278833301 abstract "Endothelial cells (ECs) are essential for pancreas differentiation, endocrine specification, and endocrine function. They are also involved in the physiopathology of type 1 and type 2 diabetes. During embryogenesis, aortic ECs provide specific factors that maintain the expression of key genes for pancreas development such as pancreatic and duodenal homeobox-1. Other unknown factors are also important for pancreatic endocrine specification and formation of insulin-producing beta cells. Endocrine precursors proliferate interspersed with ductal cells and exocrine precursors and, at some point of development, these endocrine precursors migrate to pancreatic mesenchyme and start forming the islets of Langerhans. By the end of the gestation and close to birth, these islets contain immature beta cells with the capacity to express vascular endothelial growth factor and therefore to recruit ECs from the surrounding microenvironment. ECs in turn produce factors that are essential to maintain insulin secretion in pancreatic beta cells. Once assembled, a cross talk between endocrine cells and ECs maintain the integrity of islets toward an adequate function during the whole life of the adult individual. This review will focus in the EC role in the differentiation and maturation of pancreatic beta cells during embryogenesis as well as the current knowledge about the involvement of endothelium to derive pancreatic beta cells in vitro from mouse or human pluripotent stem cells." @default.
- W278833301 created "2016-06-24" @default.
- W278833301 creator A5013883228 @default.
- W278833301 creator A5030386766 @default.
- W278833301 date "2015-01-01" @default.
- W278833301 modified "2023-09-27" @default.
- W278833301 title "Endothelium-derived essential signals involved in pancreas organogenesis" @default.
- W278833301 cites W1497716328 @default.
- W278833301 cites W1544371385 @default.
- W278833301 cites W1570086652 @default.
- W278833301 cites W1587762493 @default.
- W278833301 cites W1838110840 @default.
- W278833301 cites W1963872108 @default.
- W278833301 cites W1965681567 @default.
- W278833301 cites W1968184952 @default.
- W278833301 cites W1970847396 @default.
- W278833301 cites W1971324461 @default.
- W278833301 cites W1973758764 @default.
- W278833301 cites W1977389640 @default.
- W278833301 cites W1979153207 @default.
- W278833301 cites W1980105125 @default.
- W278833301 cites W1980247655 @default.
- W278833301 cites W1981829804 @default.
- W278833301 cites W1987306181 @default.
- W278833301 cites W1988596206 @default.
- W278833301 cites W1989388378 @default.
- W278833301 cites W1990051447 @default.
- W278833301 cites W1993534485 @default.
- W278833301 cites W1993902386 @default.
- W278833301 cites W1996139868 @default.
- W278833301 cites W2001105216 @default.
- W278833301 cites W2003841601 @default.
- W278833301 cites W2004140559 @default.
- W278833301 cites W2004313228 @default.
- W278833301 cites W2006838330 @default.
- W278833301 cites W2009107648 @default.
- W278833301 cites W2010187478 @default.
- W278833301 cites W2010607835 @default.
- W278833301 cites W2013297672 @default.
- W278833301 cites W2014077602 @default.
- W278833301 cites W2014213490 @default.
- W278833301 cites W2019524333 @default.
- W278833301 cites W2020209923 @default.
- W278833301 cites W2022709209 @default.
- W278833301 cites W2023195670 @default.
- W278833301 cites W2024313361 @default.
- W278833301 cites W2025397278 @default.
- W278833301 cites W2032755996 @default.
- W278833301 cites W2046037975 @default.
- W278833301 cites W2048658464 @default.
- W278833301 cites W2051021067 @default.
- W278833301 cites W2053827428 @default.
- W278833301 cites W2054361177 @default.
- W278833301 cites W2062826885 @default.
- W278833301 cites W2064756027 @default.
- W278833301 cites W2064942894 @default.
- W278833301 cites W2071124909 @default.
- W278833301 cites W2072284064 @default.
- W278833301 cites W2072292497 @default.
- W278833301 cites W2076163424 @default.
- W278833301 cites W2078344286 @default.
- W278833301 cites W2078461891 @default.
- W278833301 cites W2079268771 @default.
- W278833301 cites W2079446179 @default.
- W278833301 cites W2084707443 @default.
- W278833301 cites W2086943348 @default.
- W278833301 cites W2088332037 @default.
- W278833301 cites W2088601895 @default.
- W278833301 cites W2088685590 @default.
- W278833301 cites W2095380487 @default.
- W278833301 cites W2096181900 @default.
- W278833301 cites W2098915229 @default.
- W278833301 cites W2100085513 @default.
- W278833301 cites W2102033695 @default.
- W278833301 cites W2104269891 @default.
- W278833301 cites W2106219965 @default.
- W278833301 cites W2110215067 @default.
- W278833301 cites W2110725022 @default.
- W278833301 cites W2112967368 @default.
- W278833301 cites W2113754447 @default.
- W278833301 cites W2115148843 @default.
- W278833301 cites W2115389601 @default.
- W278833301 cites W2116511498 @default.
- W278833301 cites W2117637410 @default.
- W278833301 cites W2118859345 @default.
- W278833301 cites W2124884216 @default.
- W278833301 cites W2125987139 @default.
- W278833301 cites W2126354094 @default.
- W278833301 cites W2127238864 @default.
- W278833301 cites W2130917664 @default.
- W278833301 cites W2132046208 @default.
- W278833301 cites W2133544685 @default.
- W278833301 cites W2140489062 @default.
- W278833301 cites W2142986021 @default.
- W278833301 cites W2143296478 @default.
- W278833301 cites W2148890861 @default.
- W278833301 cites W2158147678 @default.
- W278833301 cites W2159369466 @default.