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• W2788333890 abstract "// Hui Liu 1 and Xin-Hua Cheng 1 1 Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China Correspondence to: Xin-Hua Cheng, email: xinhua_2015@163.com Keywords: colorectal cancer, acquired drug resistance, oxaliplatin, miR-29b, SIRT1 Received: June 29, 2017      Accepted: September 23, 2017      Published: February 01, 2018 ABSTRACT Oxaliplatin is a commonly used chemotherapeutic drug for the treatment of advanced colorectal cancer. However, acquired drug resistance against oxaliplatin remains a major obstacle for efficient use of it, and mechanisms underlying oxaliplatin resistance are still required to be explored. In the present study, we exposed colorectal cancer cell line SW480 to oxaliplatin for a long time to obtain oxaliplatin-resistant colorectal cancer cell model (OR-SW480). We found that intracellular expression of miR-29b was decreased when the SW480 cells became oxaliplatin-resistant. More importantly, overexpression of miR-29b resensitized OR-SW480 cells to oxaliplatin treatment. Mechanically, gene of SIRT1 was identified to be the target of miR-29b. Overexpression of miR-29b in oxaliplatin-treated OR-SW480 decreased the expression of SIRT1 to enhance the ROS production and JNK phosphorylation, and thus promoting apoptosis via activation of caspase 9, 7 and 3. On the other hand, expression plasmid of SIRT1, N-acetyl cysteine or SP600125 (JNK specific inhibitor) abolished the effect of miR-29b on oxaliplatin-treated OR-SW480. We therefore demonstrated that miR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1/ROS/JNK pathway." @default.
• W2788333890 created "2018-03-06" @default.
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• W2788333890 date "2018-02-01" @default.
• W2788333890 modified "2023-09-26" @default.
• W2788333890 title "MiR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1" @default.
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• W2788333890 doi "https://doi.org/10.18632/oncotarget.24380" @default.
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