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• W2788343388 abstract "Recent studies have revealed how AMPK is activated inside the cell and animal tissues: in response to low glucose, AXIN tethers LKB1, by virtue of their constitutive association, to AMPK located on the surface of late endosome/lysosome. Importantly, the lysosomal v-ATPase (vacuolar ATPase)-Ragulator complex, when primed by glucose starvation or concanamycin A, facilitates AXIN/LKB1 to interact with AMPK. Here, we describe the experimental procedures of the assays for detecting the translocation of AXIN/LKB1 or the assembly of the AXIN-based AMPK-activating complexes on the late endosome/lysosome. The methods in this chapter will be useful for determining whether various metabolic stresses or pharmacological stimuli activate AMPK via the v-ATPase-Ragulator-AXIN/LKB1 axis, which also concomitantly inactivates mTORC1. Detailed protocols for determining the levels of adenylates are also described." @default.
• W2788343388 created "2018-03-06" @default.
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• W2788343388 date "2018-01-01" @default.
• W2788343388 modified "2023-10-16" @default.
• W2788343388 title "Determining AMPK Activation via the Lysosomal v-ATPase-Ragulator-AXIN/LKB1 Axis" @default.
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• W2788343388 doi "https://doi.org/10.1007/978-1-4939-7598-3_25" @default.
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