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- W2788347840 abstract "Introducing substantial numbers of new drugs in treatment armamentarium for plasma cell myeloma (PCM) has improved the depth and duration of achieved responses as well as prolongation of overall survival. Although complete responses (CR) are significantly more common with novel therapies, a majority of patients still relapse. This may be due to small populations of clonal plasma cells persisting after treatment; the phenomenon known as minimal residual disease (MRD). The prognostic role of MRD in patients with CR has been confirmed by numerous clinical trials, and recently MRD assessment has become a routine tool for evaluating how effective the latest drugs and therapy protocols are. Furthermore, the updated response criteria of IMWG (International Myeloma Working Group) have included response categories based on MRD evaluation with modern techniques characterized by at least 10 –5 sensitivity: i.e. next generation flow and next generation sequencing. In this paper, we discuss the current role of MRD in PCM, with particular emphasis on the methodology of assessing MRD by flow cytometry. In the opinion of the Polish Myeloma Consortium members, dissemination and standardization of MRD assessment in PCM may lead to improvement of PCM therapy in Poland." @default.
- W2788347840 created "2018-03-06" @default.
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- W2788347840 date "2018-02-24" @default.
- W2788347840 modified "2023-10-03" @default.
- W2788347840 title "Znaczenie minimalnej choroby resztkowej w szpiczaku plazmocytowym — Stanowisko Polskiego Konsorcjum Szpiczakowego" @default.
- W2788347840 doi "https://doi.org/10.5603/hem.2017.0036" @default.
- W2788347840 hasPublicationYear "2018" @default.
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