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• W2788349748 endingPage "1206" @default.
• W2788349748 startingPage "1190" @default.
• W2788349748 abstract "Abdominal wall repair frequently utilizes either nondegradable or biodegradable meshes, which are found to stimulate undesirable biological tissue responses or which possess suboptimal degradation rate. In this study, a biologic mesh prototype made from carbodiimide cross-linked cholecyst-derived extracellular matrix (EDCxCEM) was compared with small intestinal submucosa (Surgisis®), cross-linked bovine pericardium (Peri-Guard®), and polypropylene (Prolene®) meshes in an in vivo rabbit model. The macroscopic appearance and stereological parameters of the meshes were evaluated. Tailoring the degradation of the EDCxCEM mesh prevents untimely degradation, while allowing cellular infiltration and mesh remodeling to take place in a slower but predictable manner. The results suggest that the cross-linked biodegradable cholecyst-derived biologic mesh results in no seroma formation, low adhesion, and moderate stretching of the mesh. In contrast to Surgisis, Peri-Guard, and Prolene meshes, the EDCxCEM mesh showed a statistically significant increase in the volume fraction (Vv) of collagen (from 34% to 52.1%) in the central fibrous tissue region at both day 28 and 56. The statistically high length density (Lv), of blood vessels for the EDCxCEM mesh at 28 days was reflected also by the higher cellular activity (high Vv of fibroblast and moderate Vv of nuclei) indicating remodeling of this region in the vicinity of a slowly degrading EDCxCEM mesh. The lack of mesh area stretching/shrinkage in the EDCxCEM mesh showed that the remodeled tissue was adequate to prevent hernia formation. The stereo-histological assays suggest that the EDCxCEM delayed degradation profile supports host wound healing processes including collagen formation, cellular infiltration, and angiogenesis. The use of cross-linked CEM for abdominal wall repair is promising." @default.
• W2788349748 created "2018-03-06" @default.
• W2788349748 creator A5009248939 @default.
• W2788349748 creator A5027018298 @default.
• W2788349748 creator A5034308196 @default.
• W2788349748 creator A5048935330 @default.
• W2788349748 creator A5079732797 @default.
• W2788349748 date "2018-08-01" @default.
• W2788349748 modified "2023-10-16" @default.
• W2788349748 title "Cross-Linked Cholecyst-Derived Extracellular Matrix for Abdominal Wall Repair" @default.
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• W2788349748 doi "https://doi.org/10.1089/ten.tea.2017.0379" @default.
• W2788349748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29448888" @default.
• W2788349748 hasPublicationYear "2018" @default.

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