FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788375293> ?p ?o ?g. }

• W2788375293 abstract "Osteosarcoma is one of the most frequent types of primary malignant bone neoplasm in children and adolescents. Despite advancements developed in therapeutic modalities, the 5-year overall survival rates for patients with metastatic osteosarcoma disease remain poor. The present study aimed to investigate the expression level of microRNA-302a (miR-302a) in osteosarcoma tissues and cell lines, and the biological roles of miR-302a in osteosarcoma cells. In addition, the molecular mechanism underlying its tumor suppressive roles was evaluated. miR-302a expression in osteosarcoma tissues and cell lines was detected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Following transfection of miR-302a mimics or IGF-1R siRNA, transwell migration and invasion, luciferase reporter assay RT-qPCR and western blot assays were conducted in osteosarcoma cells. In the present study, the data demonstrated that miR-302a was frequently reduced in osteosarcoma tissue and cell lines. In addition, the expression of miR-302a was correlated with metastatic features of patients with osteosarcoma. Restoration of miR-302a expression significantly inhibited the migration and invasion capacity of osteosarcoma cells. Mechanistic studies indicated that insulin-like growth factor 1 receptor (IGF-1R) was a direct target gene of miR-302a. Overexpression of miR-302a resulted in decreased expression of IGF-1R at the mRNA and protein levels. Furthermore, the knockdown IGF-1R mimicked the functions of miR-302a overexpression on osteosarcoma cell migration and invasion. Collectively, the results of the current study indicate that miR-302a acts as a metastasis suppressing miRNA and could be investigated as a therapeutic target for the treatment of patients with osteosarcoma to prevent metastasis." @default.
• W2788375293 created "2018-03-06" @default.
• W2788375293 creator A5016650205 @default.
• W2788375293 creator A5072170257 @default.
• W2788375293 creator A5074134369 @default.
• W2788375293 creator A5087149945 @default.
• W2788375293 date "2018-02-14" @default.
• W2788375293 modified "2023-09-28" @default.
• W2788375293 title "MicroRNA-302a inhibits osteosarcoma cell migration and invasion by directly targeting IGF-1R" @default.
• W2788375293 cites W1020015644 @default.
• W2788375293 cites W1250740847 @default.
• W2788375293 cites W1488956616 @default.
• W2788375293 cites W1560640024 @default.
• W2788375293 cites W1738160483 @default.
• W2788375293 cites W1968008181 @default.
• W2788375293 cites W1987662934 @default.
• W2788375293 cites W1990061381 @default.
• W2788375293 cites W1991261473 @default.
• W2788375293 cites W1996445359 @default.
• W2788375293 cites W2004536797 @default.
• W2788375293 cites W2018596602 @default.
• W2788375293 cites W2019394924 @default.
• W2788375293 cites W2044332600 @default.
• W2788375293 cites W2045030992 @default.
• W2788375293 cites W2053855502 @default.
• W2788375293 cites W2064623669 @default.
• W2788375293 cites W2100694829 @default.
• W2788375293 cites W2107277218 @default.
• W2788375293 cites W2109600717 @default.
• W2788375293 cites W2117391818 @default.
• W2788375293 cites W2129266710 @default.
• W2788375293 cites W2150301699 @default.
• W2788375293 cites W2151932688 @default.
• W2788375293 cites W2159767268 @default.
• W2788375293 cites W2412090798 @default.
• W2788375293 cites W60627063 @default.
• W2788375293 cites W79846600 @default.
• W2788375293 cites W983312360 @default.
• W2788375293 cites W1964184380 @default.
• W2788375293 doi "https://doi.org/10.3892/ol.2018.8049" @default.
• W2788375293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5858113" @default.
• W2788375293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29563995" @default.
• W2788375293 hasPublicationYear "2018" @default.
• W2788375293 type Work @default.
• W2788375293 sameAs 2788375293 @default.
• W2788375293 citedByCount "5" @default.
• W2788375293 countsByYear W27883752932019 @default.
• W2788375293 countsByYear W27883752932020 @default.
• W2788375293 countsByYear W27883752932021 @default.
• W2788375293 crossrefType "journal-article" @default.
• W2788375293 hasAuthorship W2788375293A5016650205 @default.
• W2788375293 hasAuthorship W2788375293A5072170257 @default.
• W2788375293 hasAuthorship W2788375293A5074134369 @default.
• W2788375293 hasAuthorship W2788375293A5087149945 @default.
• W2788375293 hasBestOaLocation W27883752931 @default.
• W2788375293 hasConcept C104317684 @default.
• W2788375293 hasConcept C121608353 @default.
• W2788375293 hasConcept C126322002 @default.
• W2788375293 hasConcept C145059251 @default.
• W2788375293 hasConcept C1491633281 @default.
• W2788375293 hasConcept C173396325 @default.
• W2788375293 hasConcept C2776415932 @default.
• W2788375293 hasConcept C2777760704 @default.
• W2788375293 hasConcept C2779013556 @default.
• W2788375293 hasConcept C2781018059 @default.
• W2788375293 hasConcept C29537977 @default.
• W2788375293 hasConcept C502942594 @default.
• W2788375293 hasConcept C54009773 @default.
• W2788375293 hasConcept C54355233 @default.
• W2788375293 hasConcept C55493867 @default.
• W2788375293 hasConcept C62112901 @default.
• W2788375293 hasConcept C71924100 @default.
• W2788375293 hasConcept C81885089 @default.
• W2788375293 hasConcept C86803240 @default.
• W2788375293 hasConceptScore W2788375293C104317684 @default.
• W2788375293 hasConceptScore W2788375293C121608353 @default.
• W2788375293 hasConceptScore W2788375293C126322002 @default.
• W2788375293 hasConceptScore W2788375293C145059251 @default.
• W2788375293 hasConceptScore W2788375293C1491633281 @default.
• W2788375293 hasConceptScore W2788375293C173396325 @default.
• W2788375293 hasConceptScore W2788375293C2776415932 @default.
• W2788375293 hasConceptScore W2788375293C2777760704 @default.
• W2788375293 hasConceptScore W2788375293C2779013556 @default.
• W2788375293 hasConceptScore W2788375293C2781018059 @default.
• W2788375293 hasConceptScore W2788375293C29537977 @default.
• W2788375293 hasConceptScore W2788375293C502942594 @default.
• W2788375293 hasConceptScore W2788375293C54009773 @default.
• W2788375293 hasConceptScore W2788375293C54355233 @default.
• W2788375293 hasConceptScore W2788375293C55493867 @default.
• W2788375293 hasConceptScore W2788375293C62112901 @default.
• W2788375293 hasConceptScore W2788375293C71924100 @default.
• W2788375293 hasConceptScore W2788375293C81885089 @default.
• W2788375293 hasConceptScore W2788375293C86803240 @default.
• W2788375293 hasLocation W27883752931 @default.
• W2788375293 hasLocation W27883752932 @default.
• W2788375293 hasLocation W27883752933 @default.
• W2788375293 hasLocation W27883752934 @default.
• W2788375293 hasOpenAccess W2788375293 @default.
• W2788375293 hasPrimaryLocation W27883752931 @default.
• W2788375293 hasRelatedWork W2001686617 @default.

• next