Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788380830> ?p ?o ?g. }
- W2788380830 abstract "This study reports novel findings that link E-Cadherin-mediated force-transduction signaling to vinculin targeting to intercellular junctions via epidermal growth factor receptor (EGFR) and integrins. These results build on previous findings, which demonstrated that mechanically perturbed E-Cadherin receptors activate phosphoinositide-3-kinase and downstream integrins, in an EGFR-dependent manner. Results of this study show that this EGFR-mediated kinase cascade controls the force-dependent recruitment of vinculin to stressed E-Cadherin complexes--a key early signature of cadherin-based mechanotransduction. Vinculin targeting requires phosphorylation at tyrosine 822 by Abelson family kinase (Abl), but the origin of force-dependent Abl activation had not been identified. We now present evidence that integrin activation, which is downstream from EGFR signaling controls Abl activation, thus linking E-Cadherin to Abl through a mechanosensitive signaling network. These findings place EGFR and integrins at the center of a positive feedback loop, through which force-activated E-Cadherin signals regulate vinculin recruitment to cadherin complexes, in response to increased intercellular tension." @default.
- W2788380830 created "2018-03-06" @default.
- W2788380830 creator A5006961802 @default.
- W2788380830 creator A5027994094 @default.
- W2788380830 creator A5052206928 @default.
- W2788380830 creator A5059958365 @default.
- W2788380830 creator A5063019980 @default.
- W2788380830 creator A5066691130 @default.
- W2788380830 date "2018-01-01" @default.
- W2788380830 modified "2023-10-08" @default.
- W2788380830 title "Epidermal growth factor receptor and integrins control force-dependent vinculin recruitment to E-Cadherin junctions" @default.
- W2788380830 cites W1490283529 @default.
- W2788380830 cites W1698435208 @default.
- W2788380830 cites W1963773881 @default.
- W2788380830 cites W1965933207 @default.
- W2788380830 cites W1967489328 @default.
- W2788380830 cites W1968831085 @default.
- W2788380830 cites W1972076214 @default.
- W2788380830 cites W1976110044 @default.
- W2788380830 cites W1979681675 @default.
- W2788380830 cites W1984114593 @default.
- W2788380830 cites W1986363856 @default.
- W2788380830 cites W1988810155 @default.
- W2788380830 cites W2002478321 @default.
- W2788380830 cites W2003997440 @default.
- W2788380830 cites W2007558178 @default.
- W2788380830 cites W2009688266 @default.
- W2788380830 cites W2010087461 @default.
- W2788380830 cites W2011650280 @default.
- W2788380830 cites W2012795094 @default.
- W2788380830 cites W2015155360 @default.
- W2788380830 cites W2020325784 @default.
- W2788380830 cites W2021325289 @default.
- W2788380830 cites W2022746045 @default.
- W2788380830 cites W2022806583 @default.
- W2788380830 cites W2029991360 @default.
- W2788380830 cites W2032780005 @default.
- W2788380830 cites W2032930150 @default.
- W2788380830 cites W2035926186 @default.
- W2788380830 cites W2038976026 @default.
- W2788380830 cites W2039712657 @default.
- W2788380830 cites W2042356432 @default.
- W2788380830 cites W2042560536 @default.
- W2788380830 cites W2045464049 @default.
- W2788380830 cites W2052766715 @default.
- W2788380830 cites W2059693288 @default.
- W2788380830 cites W2060934353 @default.
- W2788380830 cites W2064771994 @default.
- W2788380830 cites W2076086205 @default.
- W2788380830 cites W2076959105 @default.
- W2788380830 cites W2081338608 @default.
- W2788380830 cites W2084457841 @default.
- W2788380830 cites W2086244192 @default.
- W2788380830 cites W2089352744 @default.
- W2788380830 cites W2089547011 @default.
- W2788380830 cites W2090106721 @default.
- W2788380830 cites W2090536111 @default.
- W2788380830 cites W2092550529 @default.
- W2788380830 cites W2096578913 @default.
- W2788380830 cites W2096767577 @default.
- W2788380830 cites W2097256807 @default.
- W2788380830 cites W2097558698 @default.
- W2788380830 cites W2098708985 @default.
- W2788380830 cites W2099052265 @default.
- W2788380830 cites W2100141065 @default.
- W2788380830 cites W2100303404 @default.
- W2788380830 cites W2105496404 @default.
- W2788380830 cites W2112688349 @default.
- W2788380830 cites W2113111549 @default.
- W2788380830 cites W2114550587 @default.
- W2788380830 cites W2116517871 @default.
- W2788380830 cites W2118260907 @default.
- W2788380830 cites W2119658007 @default.
- W2788380830 cites W2127213821 @default.
- W2788380830 cites W2128494980 @default.
- W2788380830 cites W2129955536 @default.
- W2788380830 cites W2132375258 @default.
- W2788380830 cites W2132566055 @default.
- W2788380830 cites W2133515086 @default.
- W2788380830 cites W2134208433 @default.
- W2788380830 cites W2138183010 @default.
- W2788380830 cites W2138835758 @default.
- W2788380830 cites W2139731224 @default.
- W2788380830 cites W2142501126 @default.
- W2788380830 cites W2156413973 @default.
- W2788380830 cites W2158183156 @default.
- W2788380830 cites W2158822681 @default.
- W2788380830 cites W2159835158 @default.
- W2788380830 cites W2160373069 @default.
- W2788380830 cites W2161020445 @default.
- W2788380830 cites W2169310627 @default.
- W2788380830 cites W2169563230 @default.
- W2788380830 cites W2183931507 @default.
- W2788380830 cites W2296441026 @default.
- W2788380830 cites W2303116991 @default.
- W2788380830 cites W2324443299 @default.
- W2788380830 cites W2327893020 @default.
- W2788380830 cites W2345977595 @default.
- W2788380830 cites W2476542314 @default.
- W2788380830 doi "https://doi.org/10.1242/jcs.206656" @default.