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- W2788391323 abstract "New polymers are needed to address the shortcomings of commercially available materials for soft tissue repair. Herein, we investigated a series of l-valine-based poly(ester urea)s (PEUs) that vary in monomer composition and the extent of branching as candidate materials for soft tissue repair. The preimplantation Young’s moduli (105 ± 30 to 269 ± 12 MPa) for all the PEUs are comparable to those of polypropylene (165 ± 5 MPa) materials currently employed in hernia-mesh repair. The 2% branched poly(1-VAL-8) maintained the highest Young’s modulus following 3 months of in vivo implantation (78 ± 34 MPa) when compared to other PEU analogues (20 ± 6–45 ± 5 MPa). Neither the linear or branched PEUs elicited a significant inflammatory response in vivo as noted by less fibrous capsule formation after 3 months of implantation (80 ± 38 to 103 ± 33 μm) relative to polypropylene controls (126 ± 34 μm). Mechanical degradation in vivo over three months, coupled with limited inflammatory response, suggests that l-valine..." @default.
- W2788391323 created "2018-03-06" @default.
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- W2788391323 date "2018-02-19" @default.
- W2788391323 modified "2023-09-26" @default.
- W2788391323 title "Preclinical in Vitro and in Vivo Assessment of Linear and Branched <scp>l</scp>-Valine-Based Poly(ester urea)s for Soft Tissue Applications" @default.
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- W2788391323 doi "https://doi.org/10.1021/acsbiomaterials.7b00920" @default.
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