Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788393684> ?p ?o ?g. }
- W2788393684 endingPage "2145" @default.
- W2788393684 startingPage "2133" @default.
- W2788393684 abstract "While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovascular diseases. However, the deleterious effects of long-term anti-miR-33 therapies and predisposition of miR-33−/− mice to obesity and metabolic dysfunction exemplify the possible pitfalls of miRNA-based therapies. Our work provides an in-depth characterization of miR-33−/− mice and explores the mechanisms by which loss of miR-33 promotes insulin resistance in key metabolic tissues. Contrary to previous reports, our data do not support a direct role for SREBP-1-mediated lipid synthesis in promoting these effects. Alternatively, in adipose tissue of miR-33−/− mice, we observe increased pre-adipocyte proliferation, enhanced lipid uptake, and impaired lipolysis. Moreover, we demonstrate that the driving force behind these abnormalities is increased food intake, which can be prevented by pair feeding with wild-type animals." @default.
- W2788393684 created "2018-03-06" @default.
- W2788393684 creator A5002528642 @default.
- W2788393684 creator A5006856933 @default.
- W2788393684 creator A5011059025 @default.
- W2788393684 creator A5019493482 @default.
- W2788393684 creator A5021244108 @default.
- W2788393684 creator A5022667992 @default.
- W2788393684 creator A5023015624 @default.
- W2788393684 creator A5037108469 @default.
- W2788393684 creator A5038923785 @default.
- W2788393684 creator A5043440988 @default.
- W2788393684 creator A5048379477 @default.
- W2788393684 creator A5049834976 @default.
- W2788393684 creator A5056944131 @default.
- W2788393684 creator A5066161483 @default.
- W2788393684 creator A5084560921 @default.
- W2788393684 date "2018-02-01" @default.
- W2788393684 modified "2023-10-15" @default.
- W2788393684 title "Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance" @default.
- W2788393684 cites W1187096858 @default.
- W2788393684 cites W1520671195 @default.
- W2788393684 cites W1614016872 @default.
- W2788393684 cites W1940806157 @default.
- W2788393684 cites W1969714000 @default.
- W2788393684 cites W1976840283 @default.
- W2788393684 cites W1978010345 @default.
- W2788393684 cites W1980867561 @default.
- W2788393684 cites W1989242866 @default.
- W2788393684 cites W1994174603 @default.
- W2788393684 cites W2012616814 @default.
- W2788393684 cites W2014946489 @default.
- W2788393684 cites W2022419155 @default.
- W2788393684 cites W2027744584 @default.
- W2788393684 cites W2029226240 @default.
- W2788393684 cites W2030354790 @default.
- W2788393684 cites W2031840166 @default.
- W2788393684 cites W2038315143 @default.
- W2788393684 cites W2042714431 @default.
- W2788393684 cites W2047043150 @default.
- W2788393684 cites W2070207607 @default.
- W2788393684 cites W2073803015 @default.
- W2788393684 cites W2075728036 @default.
- W2788393684 cites W2086102771 @default.
- W2788393684 cites W2098726705 @default.
- W2788393684 cites W2102842031 @default.
- W2788393684 cites W2102901373 @default.
- W2788393684 cites W2108732038 @default.
- W2788393684 cites W2123366371 @default.
- W2788393684 cites W2124615340 @default.
- W2788393684 cites W2129415792 @default.
- W2788393684 cites W2133966719 @default.
- W2788393684 cites W2142082511 @default.
- W2788393684 cites W2154236306 @default.
- W2788393684 cites W2154694480 @default.
- W2788393684 cites W2155690408 @default.
- W2788393684 cites W2158456188 @default.
- W2788393684 cites W2159167853 @default.
- W2788393684 cites W2161983036 @default.
- W2788393684 cites W2162940414 @default.
- W2788393684 cites W2167729033 @default.
- W2788393684 cites W2168964544 @default.
- W2788393684 cites W2170446809 @default.
- W2788393684 cites W2171031572 @default.
- W2788393684 cites W2180449164 @default.
- W2788393684 cites W2230222215 @default.
- W2788393684 cites W2260443647 @default.
- W2788393684 cites W2276678027 @default.
- W2788393684 cites W2531513864 @default.
- W2788393684 cites W2606837944 @default.
- W2788393684 cites W2765749432 @default.
- W2788393684 cites W4252021281 @default.
- W2788393684 doi "https://doi.org/10.1016/j.celrep.2018.01.074" @default.
- W2788393684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5860817" @default.
- W2788393684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29466739" @default.
- W2788393684 hasPublicationYear "2018" @default.
- W2788393684 type Work @default.
- W2788393684 sameAs 2788393684 @default.
- W2788393684 citedByCount "83" @default.
- W2788393684 countsByYear W27883936842018 @default.
- W2788393684 countsByYear W27883936842019 @default.
- W2788393684 countsByYear W27883936842020 @default.
- W2788393684 countsByYear W27883936842021 @default.
- W2788393684 countsByYear W27883936842022 @default.
- W2788393684 countsByYear W27883936842023 @default.
- W2788393684 crossrefType "journal-article" @default.
- W2788393684 hasAuthorship W2788393684A5002528642 @default.
- W2788393684 hasAuthorship W2788393684A5006856933 @default.
- W2788393684 hasAuthorship W2788393684A5011059025 @default.
- W2788393684 hasAuthorship W2788393684A5019493482 @default.
- W2788393684 hasAuthorship W2788393684A5021244108 @default.
- W2788393684 hasAuthorship W2788393684A5022667992 @default.
- W2788393684 hasAuthorship W2788393684A5023015624 @default.
- W2788393684 hasAuthorship W2788393684A5037108469 @default.
- W2788393684 hasAuthorship W2788393684A5038923785 @default.
- W2788393684 hasAuthorship W2788393684A5043440988 @default.
- W2788393684 hasAuthorship W2788393684A5048379477 @default.
- W2788393684 hasAuthorship W2788393684A5049834976 @default.