Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788431451> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2788431451 abstract "Wear particle-induced osteolysis is a major cause of aseptic loosening in arthroplasty failure, but the underlying mechanism remains unclear. Due to long follow-ups necessary for detection and sporadic occurrence, it is challenging to assess the pathogenesis ofparticle-induced osteolysis in clinical cases. Hence, optimal animal models are required for further studies. The murine model of calvarial osteolysis established by exposure to CoCrMo particles is an effective and valid tool for assessing the interactions between particles and various cells in aseptic loosening. In this model, CoCrMo particles were first obtained by high-vacuum three-electrode direct current and resuspended in phosphate-buffered saline at a concentration of 50 mg/mL. Then, 50 µL of the resulting suspension was applied to the middle of the murine calvaria after separation of the cranial periosteum by sharp dissection. After two weeks, the mice were sacrificed, and calvaria specimens were harvested; qualitative and quantitative evaluations were performed by hematoxylin and eosin staining and micro computed tomography. The strengths of this model include procedure simplicity, quantitative evaluation of bone loss, rapidity of osteolysis development, potential use transgenic or knockout models, and a relatively low cost. However, this model cannot to be used to assess the mechanical force and chronic effects of particles in aseptic loosening. Murine calvarial osteolysis model generated by exposure to CoCrMo particles is an ideal tool for assessing the interactions between wear particles and various cells, e.g., macrophages, fibroblasts, osteoblasts and osteoclasts, in aseptic loosening." @default.
- W2788431451 created "2018-03-06" @default.
- W2788431451 creator A5000404278 @default.
- W2788431451 creator A5005949053 @default.
- W2788431451 creator A5010101040 @default.
- W2788431451 creator A5012752622 @default.
- W2788431451 creator A5017532188 @default.
- W2788431451 creator A5030849116 @default.
- W2788431451 creator A5031755077 @default.
- W2788431451 creator A5048152613 @default.
- W2788431451 creator A5062035232 @default.
- W2788431451 creator A5086969004 @default.
- W2788431451 date "2018-02-17" @default.
- W2788431451 modified "2023-10-16" @default.
- W2788431451 title "Construction and Evaluation of a Murine Calvarial Osteolysis Model by Exposure to CoCrMo Particles in Aseptic Loosening" @default.
- W2788431451 cites W1985148995 @default.
- W2788431451 cites W1990135938 @default.
- W2788431451 cites W2057146036 @default.
- W2788431451 cites W2059620118 @default.
- W2788431451 cites W2091827084 @default.
- W2788431451 cites W2175779306 @default.
- W2788431451 cites W221027302 @default.
- W2788431451 cites W2217559769 @default.
- W2788431451 cites W2300173132 @default.
- W2788431451 cites W2410645058 @default.
- W2788431451 cites W2550400579 @default.
- W2788431451 cites W2550771129 @default.
- W2788431451 cites W76099431 @default.
- W2788431451 cites W767407466 @default.
- W2788431451 doi "https://doi.org/10.3791/56276" @default.
- W2788431451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5931316" @default.
- W2788431451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29553545" @default.
- W2788431451 hasPublicationYear "2018" @default.
- W2788431451 type Work @default.
- W2788431451 sameAs 2788431451 @default.
- W2788431451 citedByCount "5" @default.
- W2788431451 countsByYear W27884314512018 @default.
- W2788431451 countsByYear W27884314512019 @default.
- W2788431451 countsByYear W27884314512020 @default.
- W2788431451 countsByYear W27884314512021 @default.
- W2788431451 crossrefType "journal-article" @default.
- W2788431451 hasAuthorship W2788431451A5000404278 @default.
- W2788431451 hasAuthorship W2788431451A5005949053 @default.
- W2788431451 hasAuthorship W2788431451A5010101040 @default.
- W2788431451 hasAuthorship W2788431451A5012752622 @default.
- W2788431451 hasAuthorship W2788431451A5017532188 @default.
- W2788431451 hasAuthorship W2788431451A5030849116 @default.
- W2788431451 hasAuthorship W2788431451A5031755077 @default.
- W2788431451 hasAuthorship W2788431451A5048152613 @default.
- W2788431451 hasAuthorship W2788431451A5062035232 @default.
- W2788431451 hasAuthorship W2788431451A5086969004 @default.
- W2788431451 hasBestOaLocation W27884314512 @default.
- W2788431451 hasConcept C125473707 @default.
- W2788431451 hasConcept C141071460 @default.
- W2788431451 hasConcept C142724271 @default.
- W2788431451 hasConcept C185592680 @default.
- W2788431451 hasConcept C202751555 @default.
- W2788431451 hasConcept C2779918246 @default.
- W2788431451 hasConcept C2781282405 @default.
- W2788431451 hasConcept C55493867 @default.
- W2788431451 hasConcept C71924100 @default.
- W2788431451 hasConcept C74864618 @default.
- W2788431451 hasConceptScore W2788431451C125473707 @default.
- W2788431451 hasConceptScore W2788431451C141071460 @default.
- W2788431451 hasConceptScore W2788431451C142724271 @default.
- W2788431451 hasConceptScore W2788431451C185592680 @default.
- W2788431451 hasConceptScore W2788431451C202751555 @default.
- W2788431451 hasConceptScore W2788431451C2779918246 @default.
- W2788431451 hasConceptScore W2788431451C2781282405 @default.
- W2788431451 hasConceptScore W2788431451C55493867 @default.
- W2788431451 hasConceptScore W2788431451C71924100 @default.
- W2788431451 hasConceptScore W2788431451C74864618 @default.
- W2788431451 hasIssue "132" @default.
- W2788431451 hasLocation W27884314511 @default.
- W2788431451 hasLocation W27884314512 @default.
- W2788431451 hasLocation W27884314513 @default.
- W2788431451 hasLocation W27884314514 @default.
- W2788431451 hasOpenAccess W2788431451 @default.
- W2788431451 hasPrimaryLocation W27884314511 @default.
- W2788431451 hasRelatedWork W2000974654 @default.
- W2788431451 hasRelatedWork W2005968626 @default.
- W2788431451 hasRelatedWork W2099247361 @default.
- W2788431451 hasRelatedWork W2133715015 @default.
- W2788431451 hasRelatedWork W2174128729 @default.
- W2788431451 hasRelatedWork W2378210841 @default.
- W2788431451 hasRelatedWork W2378366845 @default.
- W2788431451 hasRelatedWork W2574655763 @default.
- W2788431451 hasRelatedWork W2788431451 @default.
- W2788431451 hasRelatedWork W4286851762 @default.
- W2788431451 isParatext "false" @default.
- W2788431451 isRetracted "false" @default.
- W2788431451 magId "2788431451" @default.
- W2788431451 workType "article" @default.