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- W2788457772 endingPage "158" @default.
- W2788457772 startingPage "147" @default.
- W2788457772 abstract "AMP-activated protein kinase (AMPK) is an evolutionary conserved and ubiquitously expressed serine/threonine kinase playing a central role in the coordination of energy homeostasis. Based on the beneficial outcomes of its activation on metabolism, AMPK has emerged as an attractive target for the treatment of metabolic diseases. Identification of novel downstream targets of AMPK beyond the regulation of energy metabolism has renewed considerable attention in exploiting AMPK signaling for novel therapeutic targeting strategies including treatment of cancer and inflammatory diseases. The complexity of AMPK system with tissue- and species-specific expression of multiple isoform combination regulated by various inputs, post-traductional modifications and subcellular locations presents unique challenges for drug discovery. Here, we review the most recent advances in the understanding of the mechanism(s) of action of direct small molecule AMPK activators and the potential therapeutic opportunities." @default.
- W2788457772 created "2018-03-06" @default.
- W2788457772 creator A5043636167 @default.
- W2788457772 creator A5045765280 @default.
- W2788457772 creator A5080161168 @default.
- W2788457772 date "2018-07-01" @default.
- W2788457772 modified "2023-10-09" @default.
- W2788457772 title "Promise and challenges for direct small molecule AMPK activators" @default.
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