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• W2788458738 abstract "ABSTRACT Cyclic diguanylate (c-di-GMP) is a second messenger that regulates the transition from motile to sessile lifestyles in numerous bacteria and controls virulence factor production in a variety of pathogens. In Clostridium difficile , c-di-GMP negatively regulates flagellum biosynthesis and swimming motility and promotes the production of type IV pili (TFP), biofilm formation, and surface motility in vitro . Flagella have been identified as colonization factors in C. difficile , but the role of TFP in adherence to host cells and in colonization of the mammalian gut is unknown. Here we show that c-di-GMP promotes adherence to epithelial cells in vitro , which can be partly attributed to the loss of flagella. Using TFP-null mutants, we demonstrate that adherence to epithelial cells is partially mediated by TFP and that this TFP-mediated adherence requires c-di-GMP regulation. In a mouse model of colonization, the TFP-null mutants initially colonized the intestine as well as the parental strain but were cleared more quickly. Moreover, compared to the parent strain, C. difficile strains lacking TFP were particularly deficient in association with the cecal mucosa. Together these data indicate that TFP and their positive regulation by c-di-GMP promote attachment of C. difficile to the intestinal epithelium and contribute to persistence of C. difficile in the host intestine." @default.
• W2788458738 created "2018-03-06" @default.
• W2788458738 creator A5011326221 @default.
• W2788458738 creator A5028785471 @default.
• W2788458738 creator A5043048142 @default.
• W2788458738 creator A5084941155 @default.
• W2788458738 date "2018-05-01" @default.
• W2788458738 modified "2023-10-14" @default.
• W2788458738 title "Type IV Pili Promote Clostridium difficile Adherence and Persistence in a Mouse Model of Infection" @default.
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• W2788458738 doi "https://doi.org/10.1128/iai.00943-17" @default.
• W2788458738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5913833" @default.

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