FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788480653> ?p ?o ?g. }

• W2788480653 abstract "Cathepsin G (CG) is a myeloid azurophil granule protease that is highly expressed by acute myeloid leukemia (AML) blasts and leukemia stem cells. We previously identified CG1 (FLLPTGAEA), an HLA-A2-restricted nonameric peptide derived from CG, as an immunogenic target in AML. In this report, we aimed to assess the level of CG expression in acute lymphoid leukemia (ALL) and its potential as an immunotherapeutic target in ALL. Using RT-PCR and western blotting, we identified CG mRNA and protein, respectively, in ALL patient samples and cell lines. We also examined CG expression in a large cohort of 130 patients with ALL via reverse-phase protein array (RPPA). Our data show that CG is widely expressed by ALL and is a poor prognosticator. In addition to endogenous expression, we also provide evidence that CG can be taken up by ALL cells. Lastly, we demonstrate that patient ALL can be lysed by CG1-specific CTLs in vitro. Together, these data show high expression of CG by ALL and implicate CG as a target for immunotherapy in ALL." @default.
• W2788480653 created "2018-03-06" @default.
• W2788480653 creator A5003809226 @default.
• W2788480653 creator A5006510707 @default.
• W2788480653 creator A5013197884 @default.
• W2788480653 creator A5016607292 @default.
• W2788480653 creator A5018907752 @default.
• W2788480653 creator A5026497057 @default.
• W2788480653 creator A5026977205 @default.
• W2788480653 creator A5029062544 @default.
• W2788480653 creator A5029855695 @default.
• W2788480653 creator A5035961942 @default.
• W2788480653 creator A5047806967 @default.
• W2788480653 creator A5048775547 @default.
• W2788480653 creator A5055925834 @default.
• W2788480653 creator A5060578744 @default.
• W2788480653 creator A5063319118 @default.
• W2788480653 creator A5072649278 @default.
• W2788480653 creator A5078173980 @default.
• W2788480653 creator A5079345641 @default.
• W2788480653 creator A5089859116 @default.
• W2788480653 creator A5091133884 @default.
• W2788480653 date "2018-01-25" @default.
• W2788480653 modified "2023-09-26" @default.
• W2788480653 title "Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target" @default.
• W2788480653 cites W1482758361 @default.
• W2788480653 cites W1494334863 @default.
• W2788480653 cites W1555553634 @default.
• W2788480653 cites W1597610606 @default.
• W2788480653 cites W1960162945 @default.
• W2788480653 cites W1977380325 @default.
• W2788480653 cites W1980962108 @default.
• W2788480653 cites W1981120003 @default.
• W2788480653 cites W1989476939 @default.
• W2788480653 cites W1997287998 @default.
• W2788480653 cites W2011832904 @default.
• W2788480653 cites W2013638297 @default.
• W2788480653 cites W2018847450 @default.
• W2788480653 cites W2025970420 @default.
• W2788480653 cites W2026820323 @default.
• W2788480653 cites W2029904937 @default.
• W2788480653 cites W2031897049 @default.
• W2788480653 cites W2048600941 @default.
• W2788480653 cites W2053650046 @default.
• W2788480653 cites W2055482234 @default.
• W2788480653 cites W2057624501 @default.
• W2788480653 cites W2059654627 @default.
• W2788480653 cites W2064773757 @default.
• W2788480653 cites W2066880509 @default.
• W2788480653 cites W2073057865 @default.
• W2788480653 cites W2076218991 @default.
• W2788480653 cites W2079439306 @default.
• W2788480653 cites W2086641174 @default.
• W2788480653 cites W2091784495 @default.
• W2788480653 cites W2096176750 @default.
• W2788480653 cites W2098888044 @default.
• W2788480653 cites W2104347367 @default.
• W2788480653 cites W2105400883 @default.
• W2788480653 cites W2113262318 @default.
• W2788480653 cites W2114629265 @default.
• W2788480653 cites W2117057528 @default.
• W2788480653 cites W2118796952 @default.
• W2788480653 cites W2126983941 @default.
• W2788480653 cites W2128870032 @default.
• W2788480653 cites W2131914577 @default.
• W2788480653 cites W2139451012 @default.
• W2788480653 cites W2145692538 @default.
• W2788480653 cites W2145985838 @default.
• W2788480653 cites W2344032126 @default.
• W2788480653 cites W2472891656 @default.
• W2788480653 cites W2507900780 @default.
• W2788480653 cites W2519109143 @default.
• W2788480653 cites W2594816776 @default.
• W2788480653 cites W2610184382 @default.
• W2788480653 cites W2745792339 @default.
• W2788480653 cites W319578897 @default.
• W2788480653 doi "https://doi.org/10.3389/fimmu.2017.01975" @default.
• W2788480653 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5790053" @default.
• W2788480653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29422892" @default.
• W2788480653 hasPublicationYear "2018" @default.
• W2788480653 type Work @default.
• W2788480653 sameAs 2788480653 @default.
• W2788480653 citedByCount "16" @default.
• W2788480653 countsByYear W27884806532018 @default.
• W2788480653 countsByYear W27884806532019 @default.
• W2788480653 countsByYear W27884806532020 @default.
• W2788480653 countsByYear W27884806532021 @default.
• W2788480653 countsByYear W27884806532022 @default.
• W2788480653 crossrefType "journal-article" @default.
• W2788480653 hasAuthorship W2788480653A5003809226 @default.
• W2788480653 hasAuthorship W2788480653A5006510707 @default.
• W2788480653 hasAuthorship W2788480653A5013197884 @default.
• W2788480653 hasAuthorship W2788480653A5016607292 @default.
• W2788480653 hasAuthorship W2788480653A5018907752 @default.
• W2788480653 hasAuthorship W2788480653A5026497057 @default.
• W2788480653 hasAuthorship W2788480653A5026977205 @default.
• W2788480653 hasAuthorship W2788480653A5029062544 @default.
• W2788480653 hasAuthorship W2788480653A5029855695 @default.
• W2788480653 hasAuthorship W2788480653A5035961942 @default.
• W2788480653 hasAuthorship W2788480653A5047806967 @default.

• next