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- W2788495074 abstract "Myeloperoxidase (MPO), found mainly in neutrophils, is released in inflammation. MPO produces reactive halogen species (RHS), which are bactericidal agents. However, RHS overproduction, i.e., halogenative stress, can also damage host biomolecules, and MPO itself may be targeted by RHS. Therefore, we examined the susceptibility of MPO to inactivation by its primary products (HOCl, HOBr, HOSCN) and secondary products such as taurine monochloramine (TauCl) and taurine monobromamine (TauBr). MPO was dose-dependently inhibited up to complete inactivity by treatment with HOCl or HOBr. TauBr diminished the activity but did not eliminate it. TauCl had no effect. MPO became inactivated when producing HOCl or HOBr but not HOSCN. Taurine protected MPO against inactivation when MPO was catalyzing oxidation of Cl − to HOCl, whereas taurine failed to prevent inactivation when MPO was working with Br − , either alone or in combination with Cl − . SCN − interfered with HOCl-mediated MPO inhibition. UV–vis spectra showed that heme degradation is involved in HOCl- and HOBr-mediated MPO inactivation. A negative linear correlation between the remaining chlorinating activity of HOCl- or HOBr-modified MPO and Escherichia coli survival upon incubation with MPO/H 2 O 2 /Cl − was found. This study elucidated the possibility of MPO downregulation by MPO-derived RHS, which could counteract halogenative stress." @default.
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- W2788495074 date "2018-10-01" @default.
- W2788495074 modified "2023-09-27" @default.
- W2788495074 title "Enzymatic and bactericidal activity of myeloperoxidase in conditions of halogenative stress" @default.
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- W2788495074 doi "https://doi.org/10.1139/bcb-2017-0292" @default.
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