FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788509617> ?p ?o ?g. }

• W2788509617 endingPage "e311" @default.
• W2788509617 startingPage "e305" @default.
• W2788509617 abstract "Central neurocytomas (CNs) are rare World Health Organization grade II tumors managed with surgery and radiation therapy. We report our experience in managing CN with proton beam therapy (PBT) when radiation therapy was used.We identified 61 patients with pathologically diagnosed CN treated at our institution between 1996 and 2016, of which 24 met inclusion criteria. Patient, tumor, and treatment characteristics are reported in context of progression-free survival and treatment-related adverse events.Of 24 patients identified, median age at diagnosis was 21 years (range, 14-60). Median maximal tumor diameter was 4.5 cm (range, 1.4-6.8). Eighteen (75%) patients underwent upfront surgery alone. Sixteen (67%) patients received adjuvant or salvage PBT at a median dose of 54 Gy (relative biological effectiveness). Median follow-up was 56 months. Median progression-free survival (PFS) was 61 months. Eleven patients had disease progression with median time to progression of 22 months. Of the 5 patients with gross total resection, 4 experienced local recurrence and had MIB-1 >4% (range, 4.5-30). There was improved PFS with addition of PBT to definitive surgery (log-rank, P = .06); there was no disease progression to date. In patients who experienced disease recurrence/progression, MIB-1 <4% was associated with improved PFS (log-rank, P = .007). All patients tolerated PBT well with toxicities typical for cranial irradiation and with no grade 3+ toxicities.In our cohort, CN with elevated MIB-1 index were at increased risk for disease progression. However, adjuvant radiation therapy appears to effectively prevent failure. PBT toxicities appear to be comparable to if not less than published photon experiences." @default.
• W2788509617 created "2018-03-06" @default.
• W2788509617 creator A5001528733 @default.
• W2788509617 creator A5005526815 @default.
• W2788509617 creator A5014884181 @default.
• W2788509617 creator A5017047283 @default.
• W2788509617 creator A5025019343 @default.
• W2788509617 creator A5028403057 @default.
• W2788509617 creator A5044861850 @default.
• W2788509617 creator A5045425111 @default.
• W2788509617 creator A5051730720 @default.
• W2788509617 creator A5075285781 @default.
• W2788509617 date "2018-09-01" @default.
• W2788509617 modified "2023-10-18" @default.
• W2788509617 title "The role of proton beam therapy in central neurocytoma: A single-institution experience" @default.
• W2788509617 cites W1481682536 @default.
• W2788509617 cites W1537138986 @default.
• W2788509617 cites W165805032 @default.
• W2788509617 cites W1969131180 @default.
• W2788509617 cites W1975835801 @default.
• W2788509617 cites W1983462431 @default.
• W2788509617 cites W1985256143 @default.
• W2788509617 cites W1991158660 @default.
• W2788509617 cites W1991251712 @default.
• W2788509617 cites W1992839443 @default.
• W2788509617 cites W2019242804 @default.
• W2788509617 cites W2025155346 @default.
• W2788509617 cites W2027597720 @default.
• W2788509617 cites W2029034627 @default.
• W2788509617 cites W2029896053 @default.
• W2788509617 cites W2048940030 @default.
• W2788509617 cites W2052276288 @default.
• W2788509617 cites W2055155813 @default.
• W2788509617 cites W2072927645 @default.
• W2788509617 cites W2074535917 @default.
• W2788509617 cites W2074716071 @default.
• W2788509617 cites W2075713557 @default.
• W2788509617 cites W2077691937 @default.
• W2788509617 cites W2082297598 @default.
• W2788509617 cites W2084392689 @default.
• W2788509617 cites W2090836475 @default.
• W2788509617 cites W2091995847 @default.
• W2788509617 cites W2119706821 @default.
• W2788509617 cites W2121160427 @default.
• W2788509617 cites W2130591352 @default.
• W2788509617 cites W2148165927 @default.
• W2788509617 cites W2159009621 @default.
• W2788509617 cites W2160382843 @default.
• W2788509617 cites W2161282046 @default.
• W2788509617 cites W2163320912 @default.
• W2788509617 cites W2312564444 @default.
• W2788509617 cites W2366536035 @default.
• W2788509617 cites W2615913332 @default.
• W2788509617 cites W3190575028 @default.
• W2788509617 doi "https://doi.org/10.1016/j.prro.2018.02.005" @default.
• W2788509617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29706302" @default.
• W2788509617 hasPublicationYear "2018" @default.
• W2788509617 type Work @default.
• W2788509617 sameAs 2788509617 @default.
• W2788509617 citedByCount "1" @default.
• W2788509617 countsByYear W27885096172022 @default.
• W2788509617 crossrefType "journal-article" @default.
• W2788509617 hasAuthorship W2788509617A5001528733 @default.
• W2788509617 hasAuthorship W2788509617A5005526815 @default.
• W2788509617 hasAuthorship W2788509617A5014884181 @default.
• W2788509617 hasAuthorship W2788509617A5017047283 @default.
• W2788509617 hasAuthorship W2788509617A5025019343 @default.
• W2788509617 hasAuthorship W2788509617A5028403057 @default.
• W2788509617 hasAuthorship W2788509617A5044861850 @default.
• W2788509617 hasAuthorship W2788509617A5045425111 @default.
• W2788509617 hasAuthorship W2788509617A5051730720 @default.
• W2788509617 hasAuthorship W2788509617A5075285781 @default.
• W2788509617 hasConcept C121608353 @default.
• W2788509617 hasConcept C126322002 @default.
• W2788509617 hasConcept C126838900 @default.
• W2788509617 hasConcept C141071460 @default.
• W2788509617 hasConcept C143409427 @default.
• W2788509617 hasConcept C151730666 @default.
• W2788509617 hasConcept C197934379 @default.
• W2788509617 hasConcept C2776694085 @default.
• W2788509617 hasConcept C2777223053 @default.
• W2788509617 hasConcept C2777982462 @default.
• W2788509617 hasConcept C2779256057 @default.
• W2788509617 hasConcept C2779343474 @default.
• W2788509617 hasConcept C2780739268 @default.
• W2788509617 hasConcept C509974204 @default.
• W2788509617 hasConcept C71924100 @default.
• W2788509617 hasConcept C72563966 @default.
• W2788509617 hasConcept C86803240 @default.
• W2788509617 hasConceptScore W2788509617C121608353 @default.
• W2788509617 hasConceptScore W2788509617C126322002 @default.
• W2788509617 hasConceptScore W2788509617C126838900 @default.
• W2788509617 hasConceptScore W2788509617C141071460 @default.
• W2788509617 hasConceptScore W2788509617C143409427 @default.
• W2788509617 hasConceptScore W2788509617C151730666 @default.
• W2788509617 hasConceptScore W2788509617C197934379 @default.
• W2788509617 hasConceptScore W2788509617C2776694085 @default.
• W2788509617 hasConceptScore W2788509617C2777223053 @default.

• next