FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788530992> ?p ?o ?g. }

• W2788530992 abstract "The activation of specific gene expression programs depends on the presence of the appropriate signals and the competence of cells to respond to these signals. Although it is well-established that cellular competence is regulated in space and time, the molecular mechanisms underlying the loss of competence remain largely unknown. Here we determine the time-window during which zebrafish prospective ectoderm loses its ability to respond to Nodal signals, and show that this coincides with a decrease in the levels of the Nodal co-receptor one-eyed pinhead (oep). Bypassing Oep using a photoactivatable receptor, or an Oep-independent ligand, allows activation of Nodal target genes for an extended period of time. These results suggest that the reduced expression of Oep causes the loss of responsiveness to Nodal signals in the prospective ectoderm. Indeed, extending the presence of Oep prolongs the window of competence to respond to Nodal signals. Our findings suggest a simple mechanism in which the decreasing level of one component of the Nodal signaling pathway regulates the loss of mesendodermal competence in the prospective ectoderm." @default.
• W2788530992 created "2018-03-06" @default.
• W2788530992 creator A5011276444 @default.
• W2788530992 creator A5057791200 @default.
• W2788530992 creator A5061865787 @default.
• W2788530992 date "2018-01-01" @default.
• W2788530992 modified "2023-09-24" @default.
• W2788530992 title "Reduced expression of the Nodal coreceptor Oep causes loss of mesendodermal competence in zebrafish" @default.
• W2788530992 cites W1486617321 @default.
• W2788530992 cites W1489916230 @default.
• W2788530992 cites W1635724305 @default.
• W2788530992 cites W1866582684 @default.
• W2788530992 cites W1948968745 @default.
• W2788530992 cites W1970137087 @default.
• W2788530992 cites W1976880781 @default.
• W2788530992 cites W1979646592 @default.
• W2788530992 cites W1982041174 @default.
• W2788530992 cites W2005235338 @default.
• W2788530992 cites W2012202122 @default.
• W2788530992 cites W2022138535 @default.
• W2788530992 cites W2028861424 @default.
• W2788530992 cites W2036806964 @default.
• W2788530992 cites W2049868101 @default.
• W2788530992 cites W2052142480 @default.
• W2788530992 cites W2053188090 @default.
• W2788530992 cites W2064736822 @default.
• W2788530992 cites W2067545062 @default.
• W2788530992 cites W2082955515 @default.
• W2788530992 cites W2087907885 @default.
• W2788530992 cites W2090596888 @default.
• W2788530992 cites W2104065792 @default.
• W2788530992 cites W2120052546 @default.
• W2788530992 cites W2127071442 @default.
• W2788530992 cites W2127933166 @default.
• W2788530992 cites W2130840634 @default.
• W2788530992 cites W2131037997 @default.
• W2788530992 cites W2140108163 @default.
• W2788530992 cites W2140443734 @default.
• W2788530992 cites W2141225969 @default.
• W2788530992 cites W2161614747 @default.
• W2788530992 cites W2166658859 @default.
• W2788530992 cites W2196899564 @default.
• W2788530992 cites W2341979757 @default.
• W2788530992 cites W2467474458 @default.
• W2788530992 cites W2495238549 @default.
• W2788530992 cites W2513354020 @default.
• W2788530992 cites W2583541384 @default.
• W2788530992 cites W2586247640 @default.
• W2788530992 cites W2595640368 @default.
• W2788530992 cites W4211028684 @default.
• W2788530992 doi "https://doi.org/10.1242/dev.158832" @default.
• W2788530992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29440298" @default.
• W2788530992 hasPublicationYear "2018" @default.
• W2788530992 type Work @default.
• W2788530992 sameAs 2788530992 @default.
• W2788530992 citedByCount "11" @default.
• W2788530992 countsByYear W27885309922019 @default.
• W2788530992 countsByYear W27885309922020 @default.
• W2788530992 countsByYear W27885309922021 @default.
• W2788530992 countsByYear W27885309922022 @default.
• W2788530992 crossrefType "journal-article" @default.
• W2788530992 hasAuthorship W2788530992A5011276444 @default.
• W2788530992 hasAuthorship W2788530992A5057791200 @default.
• W2788530992 hasAuthorship W2788530992A5061865787 @default.
• W2788530992 hasBestOaLocation W27885309921 @default.
• W2788530992 hasConcept C104317684 @default.
• W2788530992 hasConcept C127716648 @default.
• W2788530992 hasConcept C2776878037 @default.
• W2788530992 hasConcept C2779329299 @default.
• W2788530992 hasConcept C54355233 @default.
• W2788530992 hasConcept C83330619 @default.
• W2788530992 hasConcept C86803240 @default.
• W2788530992 hasConcept C87073359 @default.
• W2788530992 hasConcept C95444343 @default.
• W2788530992 hasConceptScore W2788530992C104317684 @default.
• W2788530992 hasConceptScore W2788530992C127716648 @default.
• W2788530992 hasConceptScore W2788530992C2776878037 @default.
• W2788530992 hasConceptScore W2788530992C2779329299 @default.
• W2788530992 hasConceptScore W2788530992C54355233 @default.
• W2788530992 hasConceptScore W2788530992C83330619 @default.
• W2788530992 hasConceptScore W2788530992C86803240 @default.
• W2788530992 hasConceptScore W2788530992C87073359 @default.
• W2788530992 hasConceptScore W2788530992C95444343 @default.
• W2788530992 hasFunder F4320307846 @default.
• W2788530992 hasLocation W27885309921 @default.
• W2788530992 hasLocation W27885309922 @default.
• W2788530992 hasOpenAccess W2788530992 @default.
• W2788530992 hasPrimaryLocation W27885309921 @default.
• W2788530992 hasRelatedWork W2023572900 @default.
• W2788530992 hasRelatedWork W2050950232 @default.
• W2788530992 hasRelatedWork W2060958215 @default.
• W2788530992 hasRelatedWork W2141735759 @default.
• W2788530992 hasRelatedWork W2143066563 @default.
• W2788530992 hasRelatedWork W2157166663 @default.
• W2788530992 hasRelatedWork W2165322027 @default.
• W2788530992 hasRelatedWork W2902341958 @default.
• W2788530992 hasRelatedWork W3179054707 @default.
• W2788530992 hasRelatedWork W75491002 @default.
• W2788530992 isParatext "false" @default.
• W2788530992 isRetracted "false" @default.

• next