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• W2788586615 endingPage "472" @default.
• W2788586615 startingPage "460" @default.
• W2788586615 abstract "NK cells and other innate lymphoid cells may actually be redundant for protective immunity. NK cells have the potential to induce deleterious effects in multiple settings, including autoimmunity, infections, and cancer. Depending on the systemic and local microenvironment (cells, cytokines, chemokines, extracellular vesicles), NK cells may hinder a normal immune response or become aggressive towards normal autologous or allogeneic (in the case of transplantation) cells, either via cytotoxic activity or through cytokine production. There is major controversy about the role of NK cells in the context of reproductive failure, because different influential authors have conflicting views on the topic. NK cells can be educated through proteins other than MHC class I molecules, for example the inhibitory receptor TIGIT. Immune responses are critical for the maintenance of homeostasis but can also upset the equilibrium, depending on the context and magnitude of the response. Natural killer (NK) cells are well known for their important roles in antiviral and antitumor immune responses, and they are currently used, mostly under optimized forms, as immunotherapeutic agents against cancer. Nevertheless, with accumulating examples of deleterious effects of NK cells, it is paramount to consider their negative contributions. Here, we critically review and comment on the literature surrounding undesirable aspects of NK cell activity, focusing on situations where they play a harmful rather than a protective role. Immune responses are critical for the maintenance of homeostasis but can also upset the equilibrium, depending on the context and magnitude of the response. Natural killer (NK) cells are well known for their important roles in antiviral and antitumor immune responses, and they are currently used, mostly under optimized forms, as immunotherapeutic agents against cancer. Nevertheless, with accumulating examples of deleterious effects of NK cells, it is paramount to consider their negative contributions. Here, we critically review and comment on the literature surrounding undesirable aspects of NK cell activity, focusing on situations where they play a harmful rather than a protective role. killing of an antibody-coated target cell by a cytotoxic effector cell. medical procedure using a bronchoscope for the collection of BAL fluid for the diagnosis of lung disease. steroid hormones produced by adrenal cortex, also prepared synthetically; commonly used as potent anti-inflammatory drugs. small molecules secreted by immune and other cells; examples include chemokines (attracting immune cells to sites of inflammation), interferons, and interleukins. antigen-presenting cells (APCs) that process antigens and present them to T cells; also control immune responses by secreting cytokines. a condition in which donor immune cells attack normal tissues of the recipient; GvHD can be mild, severe, or life-threatening. a cytotoxic molecule secreted by immune cells that mediates apoptosis in target cells. The human granzyme family has several members with similar functions (granzymes A, B, H, K, M). multipotent cells residing in the bone marrow that can differentiate into all blood cell lineages. these are expressed on the surface of all nucleated cells; they display peptide fragments from within the cell to cytotoxic T cells and inhibit NK cells through an interaction with inhibitory receptors. a region in which the cytoarchitecture and signaling factors within the microenvironment preserve neural stem cells (NSCs) with self-renewing capacity that give rise to new neurons and glial cells. pore-forming protein secreted by NK cells and cytotoxic T cells; acts on the surface of target cells and favors the entry of granzymes. binds to its receptor PD-1 on T cells, B cells, some NK cells, and macrophages (interaction is inhibitory for immune cells). life-threatening organ dysfunction caused by a dysregulated host response to infection. a subset of sepsis in which profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone. congenital genetic disorder caused by mutations inhibiting the development of T cells, B cells, and/or NK cells." @default.
• W2788586615 created "2018-03-06" @default.
• W2788586615 creator A5010689132 @default.
• W2788586615 creator A5034740332 @default.
• W2788586615 creator A5042852864 @default.
• W2788586615 creator A5045079036 @default.
• W2788586615 date "2018-06-01" @default.
• W2788586615 modified "2023-09-23" @default.
• W2788586615 title "Revisiting the Functional Impact of NK Cells" @default.
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