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- W2788587242 abstract "2438 Despite aggressive clinical care, glioblastoma (GBM) is a near uniformly fatal disease with median survival of 10 to 12 months. Few molecular markers exist that are prognostic for overall survival. Data from multiple expression profiling experiments suggested that the mucin-type transmembrane glycoprotein podoplanin may be a significant marker of survival. We sought to validate this finding in an independent cohort of GBM patients. Cases of GBM (WHO grade IV) or low and intermediate grade astrocytoma (WHO grade II and III) who underwent surgical resection from 11/1985 to 6/2005 with available medical records and archival formalin-fixed, paraffin-embedded (FFPE) tumor tissue were selected for this study. Podoplanin expression was detected by immunohistochemical (IHC) staining and scored as negative, intermediate, or high expression. Radiation response was previously determined in patients without a gross-total resection by evaluation of magnetic resonance imaging. Quantitative real-time PCR (QPCR) of PDPN cDNA was performed following reverse transcription of total RNA derived from FFPE tissue. A total of 113 GBMs were initially examined for podoplanin expression by IHC using the D2-40 antibody. Median survival in the podoplanin expressing group was 60 wks vs. 148 wks in the non-expressing group (p=0.008, log-rank test). This result was validated using an independent set of 95 GBMs with a 2 year survival of 52% vs. 10% (p=0.017). Median and 2-year survival among all GBMs (median follow-up of 55 weeks) for podoplanin expression vs. non-expression was 54 wks vs. 148 wks and 15% vs. 56%, respectively (p" @default.
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- W2788587242 date "2007-05-01" @default.
- W2788587242 modified "2023-09-24" @default.
- W2788587242 title "Podoplanin expression is an independent predictor of survival in malignant gliomas" @default.
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