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• W2788590302 endingPage "245" @default.
• W2788590302 startingPage "197" @default.
• W2788590302 abstract "Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have many side effects, including cognitive impairment, tolerance, rebound insomnia upon discontinuation, car accidents/falls, abuse, and dependence liability. Consequently, the clinical use of off-label drugs and novel drugs that do not target the GABAergic system is increasing. The purpose of this review is to analyze the neurobiological and clinical evidence of pharmacological treatments of insomnia, excluding the BZDs and Z-drugs. We analyzed the melatonergic agonist drugs, agomelatine, prolonged-release melatonin, ramelteon, and tasimelteon; the dual orexin receptor antagonist suvorexant; the modulators of the α2δ subunit of voltage-sensitive calcium channels, gabapentin and pregabalin; the H1 antagonist, low-dose doxepin; and the histamine and serotonin receptor antagonists, amitriptyline, mirtazapine, trazodone, olanzapine, and quetiapine. The pharmacology and mechanism of action of these treatments and the evidence-base for the use of these drugs in clinical practice is outlined along with novel pipelines. There is evidence to recommend suvorexant and low-dose doxepin for sleep maintenance insomnia; there is also sufficient evidence to recommend ramelteon for sleep onset insomnia. Although there is limited evidence for the use of the quetiapine, trazodone, mirtazapine, amitriptyline, pregabalin, gabapentin, agomelatine, and olanzapine as treatments for insomnia disorder, these drugs may improve sleep while successfully treating comorbid disorders, with a different side effect profile than the BZDs and Z-drugs. The unique mechanism of action of each drug allows for a more personalized and targeted medical management of insomnia." @default.
• W2788590302 created "2018-03-06" @default.
• W2788590302 creator A5010580951 @default.
• W2788590302 creator A5010968595 @default.
• W2788590302 creator A5018646315 @default.
• W2788590302 date "2018-02-27" @default.
• W2788590302 modified "2023-10-14" @default.
• W2788590302 title "Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery" @default.
• W2788590302 cites W11283495 @default.
• W2788590302 cites W113990517 @default.
• W2788590302 cites W145630688 @default.
• W2788590302 cites W1492264372 @default.
• W2788590302 cites W1500501438 @default.
• W2788590302 cites W1523255158 @default.
• W2788590302 cites W1524233596 @default.
• W2788590302 cites W15424833 @default.
• W2788590302 cites W1548090883 @default.
• W2788590302 cites W1581771528 @default.
• W2788590302 cites W1601733754 @default.
• W2788590302 cites W1709672860 @default.
• W2788590302 cites W1888364249 @default.
• W2788590302 cites W1895384166 @default.
• W2788590302 cites W1928942751 @default.
• W2788590302 cites W1931341966 @default.
• W2788590302 cites W1938152168 @default.
• W2788590302 cites W1949281858 @default.
• W2788590302 cites W195810818 @default.
• W2788590302 cites W1963793408 @default.
• W2788590302 cites W1963845609 @default.
• W2788590302 cites W1965355495 @default.
• W2788590302 cites W1965829294 @default.
• W2788590302 cites W1966792529 @default.
• W2788590302 cites W1969619164 @default.
• W2788590302 cites W1969855549 @default.
• W2788590302 cites W1969902328 @default.
• W2788590302 cites W1970381031 @default.
• W2788590302 cites W1971288153 @default.
• W2788590302 cites W1971924839 @default.
• W2788590302 cites W1973469708 @default.
• W2788590302 cites W1973808376 @default.
• W2788590302 cites W1976030611 @default.
• W2788590302 cites W1976288735 @default.
• W2788590302 cites W1976520993 @default.
• W2788590302 cites W1977268054 @default.
• W2788590302 cites W1977320288 @default.
• W2788590302 cites W1977592003 @default.
• W2788590302 cites W1979151764 @default.
• W2788590302 cites W1980603718 @default.
• W2788590302 cites W1980849388 @default.
• W2788590302 cites W1981070044 @default.
• W2788590302 cites W1982265404 @default.
• W2788590302 cites W1982927325 @default.
• W2788590302 cites W1984461780 @default.
• W2788590302 cites W1984708522 @default.
• W2788590302 cites W1985501047 @default.
• W2788590302 cites W1985517071 @default.
• W2788590302 cites W1985562135 @default.
• W2788590302 cites W1985598247 @default.
• W2788590302 cites W1988024350 @default.
• W2788590302 cites W1988065740 @default.
• W2788590302 cites W1988074930 @default.
• W2788590302 cites W1988981158 @default.
• W2788590302 cites W1989376957 @default.
• W2788590302 cites W1989510642 @default.
• W2788590302 cites W1990423689 @default.
• W2788590302 cites W1990757549 @default.
• W2788590302 cites W1991608264 @default.
• W2788590302 cites W1991625714 @default.
• W2788590302 cites W1991934169 @default.
• W2788590302 cites W1992543303 @default.
• W2788590302 cites W1994289021 @default.
• W2788590302 cites W1994915333 @default.
• W2788590302 cites W1995035842 @default.
• W2788590302 cites W1996211108 @default.
• W2788590302 cites W1996709320 @default.
• W2788590302 cites W1997191446 @default.
• W2788590302 cites W1997959973 @default.
• W2788590302 cites W1999452516 @default.
• W2788590302 cites W1999482712 @default.
• W2788590302 cites W2000140223 @default.
• W2788590302 cites W2001948147 @default.
• W2788590302 cites W2002624310 @default.
• W2788590302 cites W2003661541 @default.
• W2788590302 cites W2003879268 @default.
• W2788590302 cites W2004172377 @default.
• W2788590302 cites W2007788592 @default.
• W2788590302 cites W2008821456 @default.
• W2788590302 cites W2009111005 @default.
• W2788590302 cites W2009845727 @default.
• W2788590302 cites W2012660986 @default.
• W2788590302 cites W2014009131 @default.
• W2788590302 cites W2016455917 @default.
• W2788590302 cites W2018113827 @default.
• W2788590302 cites W2018441208 @default.
• W2788590302 cites W2018778450 @default.
• W2788590302 cites W2020691926 @default.
• W2788590302 cites W2021892202 @default.
• W2788590302 cites W2022094861 @default.

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