FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788615095> ?p ?o ?g. }

• W2788615095 endingPage "189" @default.
• W2788615095 startingPage "180" @default.
• W2788615095 abstract "Recent magnetic resonance spectroscopy (MRS) studies suggest that abnormalities of the glutamatergic system in schizophrenia may be dependent on illness stage, medication status, and symptomatology. Glutamatergic metabolites appear to be elevated in the prodromal and early stages of schizophrenia but unchanged or reduced below normal in chronic, medicated patients. However, few of these studies have measured metabolites with high-field 7T MR scanners, which offer higher signal-to-noise ratio and better spectral resolution than 3T scanners and facilitate separation of glutamate and glutamine into distinct signals. In this study, we examined glutamate and other metabolites in the dorsal anterior cingulate cortex (ACC) of first-episode schizophrenia patients. Glutamate and N-acetylaspartate (NAA) were significantly lower in schizophrenia patients vs controls. No differences were observed in levels of glutamine, GABA, or other metabolites. In schizophrenia patients but not controls, GABA was negatively correlated with the total score on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) as well as the immediate memory and language subscales. Our findings suggest that glutamate and NAA reductions in the ACC may be present early in the illness, but additional large-scale studies are needed to confirm these results as well as longitudinal studies to determine the effect of illness progression and treatment. The correlation between GABA and cognitive function suggests that MRS may be an important technique for investigating the neurobiology underlying cognitive deficits in schizophrenia." @default.
• W2788615095 created "2018-03-06" @default.
• W2788615095 creator A5012850293 @default.
• W2788615095 creator A5019889379 @default.
• W2788615095 creator A5031496798 @default.
• W2788615095 creator A5034093325 @default.
• W2788615095 creator A5052037843 @default.
• W2788615095 creator A5070246668 @default.
• W2788615095 date "2018-01-29" @default.
• W2788615095 modified "2023-10-17" @default.
• W2788615095 title "7T Proton Magnetic Resonance Spectroscopy of the Anterior Cingulate Cortex in First-Episode Schizophrenia" @default.
• W2788615095 cites W11922757 @default.
• W2788615095 cites W1591588997 @default.
• W2788615095 cites W1773050087 @default.
• W2788615095 cites W1907949022 @default.
• W2788615095 cites W1909972692 @default.
• W2788615095 cites W1914381346 @default.
• W2788615095 cites W1971964143 @default.
• W2788615095 cites W1973798645 @default.
• W2788615095 cites W1975448160 @default.
• W2788615095 cites W1976057168 @default.
• W2788615095 cites W1983956215 @default.
• W2788615095 cites W1988347445 @default.
• W2788615095 cites W1994737820 @default.
• W2788615095 cites W1994958750 @default.
• W2788615095 cites W2004807720 @default.
• W2788615095 cites W2013514700 @default.
• W2788615095 cites W2024251150 @default.
• W2788615095 cites W2026410709 @default.
• W2788615095 cites W2038979894 @default.
• W2788615095 cites W2057878573 @default.
• W2788615095 cites W2066003443 @default.
• W2788615095 cites W2067448851 @default.
• W2788615095 cites W2084120702 @default.
• W2788615095 cites W2087119802 @default.
• W2788615095 cites W2087788403 @default.
• W2788615095 cites W2092896191 @default.
• W2788615095 cites W2094717032 @default.
• W2788615095 cites W2102158590 @default.
• W2788615095 cites W2103592460 @default.
• W2788615095 cites W2117774616 @default.
• W2788615095 cites W2118096594 @default.
• W2788615095 cites W2121166660 @default.
• W2788615095 cites W2134462887 @default.
• W2788615095 cites W2143126574 @default.
• W2788615095 cites W2145352891 @default.
• W2788615095 cites W2147736098 @default.
• W2788615095 cites W2150265247 @default.
• W2788615095 cites W2153185503 @default.
• W2788615095 cites W2160952465 @default.
• W2788615095 cites W2166671323 @default.
• W2788615095 cites W2168814349 @default.
• W2788615095 cites W2170439773 @default.
• W2788615095 cites W2217483770 @default.
• W2788615095 cites W2278357083 @default.
• W2788615095 cites W2282891325 @default.
• W2788615095 cites W2335523060 @default.
• W2788615095 cites W2342109997 @default.
• W2788615095 cites W2414302968 @default.
• W2788615095 cites W2495579837 @default.
• W2788615095 cites W2515798032 @default.
• W2788615095 cites W2558272519 @default.
• W2788615095 cites W2559155405 @default.
• W2788615095 cites W2585397751 @default.
• W2788615095 doi "https://doi.org/10.1093/schbul/sbx190" @default.
• W2788615095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6293230" @default.
• W2788615095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29385594" @default.
• W2788615095 hasPublicationYear "2018" @default.
• W2788615095 type Work @default.
• W2788615095 sameAs 2788615095 @default.
• W2788615095 citedByCount "83" @default.
• W2788615095 countsByYear W27886150952018 @default.
• W2788615095 countsByYear W27886150952019 @default.
• W2788615095 countsByYear W27886150952020 @default.
• W2788615095 countsByYear W27886150952021 @default.
• W2788615095 countsByYear W27886150952022 @default.
• W2788615095 countsByYear W27886150952023 @default.
• W2788615095 crossrefType "journal-article" @default.
• W2788615095 hasAuthorship W2788615095A5012850293 @default.
• W2788615095 hasAuthorship W2788615095A5019889379 @default.
• W2788615095 hasAuthorship W2788615095A5031496798 @default.
• W2788615095 hasAuthorship W2788615095A5034093325 @default.
• W2788615095 hasAuthorship W2788615095A5052037843 @default.
• W2788615095 hasAuthorship W2788615095A5070246668 @default.
• W2788615095 hasBestOaLocation W27886150951 @default.
• W2788615095 hasConcept C118552586 @default.
• W2788615095 hasConcept C126322002 @default.
• W2788615095 hasConcept C14216870 @default.
• W2788615095 hasConcept C15744967 @default.
• W2788615095 hasConcept C169760540 @default.
• W2788615095 hasConcept C169900460 @default.
• W2788615095 hasConcept C170493617 @default.
• W2788615095 hasConcept C185592680 @default.
• W2788615095 hasConcept C2776412080 @default.
• W2788615095 hasConcept C2776464990 @default.
• W2788615095 hasConcept C2778402161 @default.
• W2788615095 hasConcept C2779349466 @default.
• W2788615095 hasConcept C2780648746 @default.

• next