Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788722021> ?p ?o ?g. }
- W2788722021 endingPage "1053" @default.
- W2788722021 startingPage "1044" @default.
- W2788722021 abstract "BACKGROUND:Paeoniflorin (PF), a glucoside isolated from the dried root of Paeonia lactiflora Pall, has been reported to have a number of pharmacological properties, including immunity-regulation, anticancer activities, and neuroprotective effect. However, PF’s pharmacological role in bone disorder has been seldom reported. Hence, this study was designed to investigate the effects of PF on osteoclast differentiation and osteolysis diseases. MATERIAL AND METHODS:The bone marrow macrophages were isolated from C57BL/6 mice and incubated with RANK ligand (RANKL) and various concentrations of PF. After 5 days of incubation, tartrate-resistant acid phosphatase (+) cells and bone resorption pits were counted. Effects of PF on expression of osteoclast-specific protein and gene were investigated via Western blot, q-PCR, and immunofluorescence assay. The osteoprotective effect of PF in vivo was evaluated in a calvarial osteolysis model via micro-CT scan and histological stain. RESULTS:In vitro, PF intervention inhibited osteoclast formation and resorption activity. PF also impaired RANKL-induced NF-κB phosphorylation and immigration to the nucleus. PF suppressed osteoclast-marker protein and gene expression. In vivo, PF inhibited cobalt-chromium-molybdenum alloy particle-induced osteolysis and reduced osteoclast number in tissue slice. CONCLUSIONS:PF is a potential agent against osteolysis-related diseases caused by excessive osteoclast activity." @default.
- W2788722021 created "2018-03-06" @default.
- W2788722021 creator A5034654778 @default.
- W2788722021 creator A5061098195 @default.
- W2788722021 creator A5067342400 @default.
- W2788722021 date "2018-02-20" @default.
- W2788722021 modified "2023-09-27" @default.
- W2788722021 title "Paeoniflorin Inhibits Receptor Activator for Nuclear Factor κB (RANK) Ligand-Induced Osteoclast Differentiation In Vitro and Particle-Induced Osteolysis In Vivo" @default.
- W2788722021 cites W1605803901 @default.
- W2788722021 cites W1963817481 @default.
- W2788722021 cites W1972001482 @default.
- W2788722021 cites W1979982978 @default.
- W2788722021 cites W1990028015 @default.
- W2788722021 cites W1995967690 @default.
- W2788722021 cites W1996058743 @default.
- W2788722021 cites W2002315265 @default.
- W2788722021 cites W2011949844 @default.
- W2788722021 cites W2017372504 @default.
- W2788722021 cites W2019213459 @default.
- W2788722021 cites W2020126182 @default.
- W2788722021 cites W2023156227 @default.
- W2788722021 cites W2029264336 @default.
- W2788722021 cites W2030075526 @default.
- W2788722021 cites W2031378528 @default.
- W2788722021 cites W2032132018 @default.
- W2788722021 cites W2045067396 @default.
- W2788722021 cites W2056241473 @default.
- W2788722021 cites W2057240308 @default.
- W2788722021 cites W2063746249 @default.
- W2788722021 cites W2072452605 @default.
- W2788722021 cites W2079509436 @default.
- W2788722021 cites W2090307137 @default.
- W2788722021 cites W2090348431 @default.
- W2788722021 cites W2118504962 @default.
- W2788722021 cites W2143813009 @default.
- W2788722021 cites W2147867951 @default.
- W2788722021 cites W2472990867 @default.
- W2788722021 cites W2524717026 @default.
- W2788722021 cites W2539456113 @default.
- W2788722021 cites W2542177941 @default.
- W2788722021 cites W254601787 @default.
- W2788722021 cites W2577580516 @default.
- W2788722021 cites W2584028923 @default.
- W2788722021 cites W2604176157 @default.
- W2788722021 cites W2613413757 @default.
- W2788722021 cites W2735403415 @default.
- W2788722021 cites W2737098458 @default.
- W2788722021 cites W2755688330 @default.
- W2788722021 doi "https://doi.org/10.12659/msm.907739" @default.
- W2788722021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5827632" @default.
- W2788722021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29459582" @default.
- W2788722021 hasPublicationYear "2018" @default.
- W2788722021 type Work @default.
- W2788722021 sameAs 2788722021 @default.
- W2788722021 citedByCount "5" @default.
- W2788722021 countsByYear W27887220212019 @default.
- W2788722021 countsByYear W27887220212022 @default.
- W2788722021 crossrefType "journal-article" @default.
- W2788722021 hasAuthorship W2788722021A5034654778 @default.
- W2788722021 hasAuthorship W2788722021A5061098195 @default.
- W2788722021 hasAuthorship W2788722021A5067342400 @default.
- W2788722021 hasBestOaLocation W27887220212 @default.
- W2788722021 hasConcept C126322002 @default.
- W2788722021 hasConcept C150903083 @default.
- W2788722021 hasConcept C153911025 @default.
- W2788722021 hasConcept C170493617 @default.
- W2788722021 hasConcept C179998833 @default.
- W2788722021 hasConcept C180675623 @default.
- W2788722021 hasConcept C185592680 @default.
- W2788722021 hasConcept C199343813 @default.
- W2788722021 hasConcept C202751555 @default.
- W2788722021 hasConcept C207001950 @default.
- W2788722021 hasConcept C2776033226 @default.
- W2788722021 hasConcept C2776918747 @default.
- W2788722021 hasConcept C2779428903 @default.
- W2788722021 hasConcept C2781282405 @default.
- W2788722021 hasConcept C2909639871 @default.
- W2788722021 hasConcept C43617362 @default.
- W2788722021 hasConcept C502942594 @default.
- W2788722021 hasConcept C55493867 @default.
- W2788722021 hasConcept C673006 @default.
- W2788722021 hasConcept C71924100 @default.
- W2788722021 hasConcept C86803240 @default.
- W2788722021 hasConcept C88045685 @default.
- W2788722021 hasConceptScore W2788722021C126322002 @default.
- W2788722021 hasConceptScore W2788722021C150903083 @default.
- W2788722021 hasConceptScore W2788722021C153911025 @default.
- W2788722021 hasConceptScore W2788722021C170493617 @default.
- W2788722021 hasConceptScore W2788722021C179998833 @default.
- W2788722021 hasConceptScore W2788722021C180675623 @default.
- W2788722021 hasConceptScore W2788722021C185592680 @default.
- W2788722021 hasConceptScore W2788722021C199343813 @default.
- W2788722021 hasConceptScore W2788722021C202751555 @default.
- W2788722021 hasConceptScore W2788722021C207001950 @default.
- W2788722021 hasConceptScore W2788722021C2776033226 @default.
- W2788722021 hasConceptScore W2788722021C2776918747 @default.
- W2788722021 hasConceptScore W2788722021C2779428903 @default.
- W2788722021 hasConceptScore W2788722021C2781282405 @default.