FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788745811> ?p ?o ?g. }

• W2788745811 endingPage "227" @default.
• W2788745811 startingPage "215" @default.
• W2788745811 abstract "<b><i>Background:</i></b> Neuroinflammation triggered by infection or trauma is the cause of central nervous system dysfunction. High-mobility group box 1 protein (HMGB1), released from stressed and dying brain cells, is a potent neuroinflammatory mediator. The proinflammatory functions of HMGB1 are tightly regulated by post-translational redox modifications, and we here investigated detailed neuroinflammatory responses induced by the individual redox isoforms. <b><i>Methods:</i></b> Male Dark Agouti rats received a stereotactic injection of saline, lipopolysaccharide, disulfide HMGB1, or fully reduced HMGB1, and were accessed for blood-brain barrier modifications using magnetic resonance imaging (MRI) and inflammatory responses by immunohistochemistry. <b><i>Results and Conclusions:</i></b> Significant blood-brain barrier disruption appeared 24 h after injection of lipopolysaccharide, disulfide HMGB1, or fully reduced HMGB1 compared to controls, as assessed in post-gadolinium T1-weighted MRI images and confirmed by increased uptake of FITC-conjugated dextran. Immunohistochemistry revealed that both HMGB1 isoforms also induced a local production of IL-1β. Additionally, disulfide HMGB1 increased major histocompatibility complex class II expression and apoptosis. Together, the results demonstrate that extracellular, cerebral HMGB1 causes significant blood-brain barrier disruption in a redox-independent manner and activates several components of neuroinflammation. Blocking HMGB1 might potentially improve clinical outcome in conditions such as stroke and traumatic brain injury." @default.
• W2788745811 created "2018-03-06" @default.
• W2788745811 creator A5009969580 @default.
• W2788745811 creator A5010564587 @default.
• W2788745811 creator A5015283420 @default.
• W2788745811 creator A5030023573 @default.
• W2788745811 creator A5037920234 @default.
• W2788745811 creator A5052851685 @default.
• W2788745811 creator A5057426917 @default.
• W2788745811 creator A5063521333 @default.
• W2788745811 creator A5078542779 @default.
• W2788745811 date "2018-01-01" @default.
• W2788745811 modified "2023-10-03" @default.
• W2788745811 title "Neuroinflammation in Response to Intracerebral Injections of Different HMGB1 Redox Isoforms" @default.
• W2788745811 cites W1672954108 @default.
• W2788745811 cites W1847797033 @default.
• W2788745811 cites W1973404097 @default.
• W2788745811 cites W1978256486 @default.
• W2788745811 cites W1987525830 @default.
• W2788745811 cites W1994190235 @default.
• W2788745811 cites W1995452189 @default.
• W2788745811 cites W2005640704 @default.
• W2788745811 cites W2012763966 @default.
• W2788745811 cites W2041441588 @default.
• W2788745811 cites W2045098547 @default.
• W2788745811 cites W2049029258 @default.
• W2788745811 cites W2051504363 @default.
• W2788745811 cites W2055750901 @default.
• W2788745811 cites W2066158538 @default.
• W2788745811 cites W2071344265 @default.
• W2788745811 cites W2078212617 @default.
• W2788745811 cites W2080126967 @default.
• W2788745811 cites W2087987871 @default.
• W2788745811 cites W2092272732 @default.
• W2788745811 cites W2103590758 @default.
• W2788745811 cites W2111565797 @default.
• W2788745811 cites W2112878230 @default.
• W2788745811 cites W2125504185 @default.
• W2788745811 cites W2128591402 @default.
• W2788745811 cites W2132280604 @default.
• W2788745811 cites W2137812201 @default.
• W2788745811 cites W2139112966 @default.
• W2788745811 cites W2141438911 @default.
• W2788745811 cites W2147259348 @default.
• W2788745811 cites W2149240296 @default.
• W2788745811 cites W2150279416 @default.
• W2788745811 cites W2151277012 @default.
• W2788745811 cites W2161971256 @default.
• W2788745811 cites W2164714222 @default.
• W2788745811 cites W2181566246 @default.
• W2788745811 cites W2260003929 @default.
• W2788745811 cites W2282761435 @default.
• W2788745811 cites W2520908617 @default.
• W2788745811 cites W2536199828 @default.
• W2788745811 cites W348277772 @default.
• W2788745811 cites W940482532 @default.
• W2788745811 doi "https://doi.org/10.1159/000487056" @default.
• W2788745811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6050639" @default.
• W2788745811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29478057" @default.
• W2788745811 hasPublicationYear "2018" @default.
• W2788745811 type Work @default.
• W2788745811 sameAs 2788745811 @default.
• W2788745811 citedByCount "37" @default.
• W2788745811 countsByYear W27887458112018 @default.
• W2788745811 countsByYear W27887458112019 @default.
• W2788745811 countsByYear W27887458112020 @default.
• W2788745811 countsByYear W27887458112021 @default.
• W2788745811 countsByYear W27887458112022 @default.
• W2788745811 countsByYear W27887458112023 @default.
• W2788745811 crossrefType "journal-article" @default.
• W2788745811 hasAuthorship W2788745811A5009969580 @default.
• W2788745811 hasAuthorship W2788745811A5010564587 @default.
• W2788745811 hasAuthorship W2788745811A5015283420 @default.
• W2788745811 hasAuthorship W2788745811A5030023573 @default.
• W2788745811 hasAuthorship W2788745811A5037920234 @default.
• W2788745811 hasAuthorship W2788745811A5052851685 @default.
• W2788745811 hasAuthorship W2788745811A5057426917 @default.
• W2788745811 hasAuthorship W2788745811A5063521333 @default.
• W2788745811 hasAuthorship W2788745811A5078542779 @default.
• W2788745811 hasBestOaLocation W27887458111 @default.
• W2788745811 hasConcept C134018914 @default.
• W2788745811 hasConcept C164027704 @default.
• W2788745811 hasConcept C185592680 @default.
• W2788745811 hasConcept C203014093 @default.
• W2788745811 hasConcept C2776914184 @default.
• W2788745811 hasConcept C2778402981 @default.
• W2788745811 hasConcept C2778754761 @default.
• W2788745811 hasConcept C2779830541 @default.
• W2788745811 hasConcept C2780545709 @default.
• W2788745811 hasConcept C529278444 @default.
• W2788745811 hasConcept C71924100 @default.
• W2788745811 hasConcept C87753298 @default.
• W2788745811 hasConceptScore W2788745811C134018914 @default.
• W2788745811 hasConceptScore W2788745811C164027704 @default.
• W2788745811 hasConceptScore W2788745811C185592680 @default.
• W2788745811 hasConceptScore W2788745811C203014093 @default.
• W2788745811 hasConceptScore W2788745811C2776914184 @default.
• W2788745811 hasConceptScore W2788745811C2778402981 @default.

• next